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View Structure Prediction Details

Protein: HNRPDL
Organism: Homo sapiens
Length: 420 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRPDL.

Description E-value Query
Range
Subject
Range
gi|74001737, gi|... - gi|74001741|ref|XP_858477.1| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein D-like is...
6.0E-60 [1..420] [1..420]
gi|109074323 - gi|109074323|ref|XP_001088510.1| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein D-lik...
3.0E-59 [1..420] [1..420]
gi|76620222, gi|... - gi|76620222|ref|XP_881910.1| PREDICTED: similar to JKTBP2 isoform 11 [Bos taurus], gi|76620212|ref|X...
5.0E-59 [1..420] [1..420]
gi|39644771 - gi|39644771|gb|AAH07392.2| HNRPDL protein [Homo sapiens]
7.0E-57 [8..420] [3..415]

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Predicted Domain #1
Region A:
Residues: [1-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVPPRLSHV PPPLFPSAPA TLASRSLSHW RPRPPRQLAP LLPSLAPSSA RQGARRAQRH  60
   61 VTAQQPSRLA GGAAIKGGRR RRPDLFRRHF KSSSIQRSAA AAAATRTARQ HPPADSSVTM 120
  121 EDMNEYSNIE EFAEGSKINA S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.39794
Match: 1fxlA
Description: Hu antigen D (Hud)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [142-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNQQDDGKMF IGGLSWDTSK KDLTEYLSRF GEVVDCTIKT DPVTGRSRGF GFVLFKDAAS  60
   61 VDKVLELKEH KLDGKLIDPK RAKALKGKEP PKKVFVGGLS PDTSEEQIKE YFGAFGEIEN 120
  121 IELPMDTKTN ERRGFCFITY TDEEPVKKLL ESRYHQIGSG KCEIKVAQPK EVYRQQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.0
Match: 1ha1A
Description: HNRNP A1 (RBD1,2) FROM HOMO SAPIENS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
4.08350076268185 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
binding 3.05116833253954 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
poly-pyrimidine tract binding 1.99190411806363 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
snRNA binding 1.12690941758278 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
protein binding 0.42571879933058 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [319-420]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQKGGRGAA AGGRGGTRGR GRGQGQNWNQ GFNNYYDQGY GNYNSAYGGD QNYSGYGGYD  60
   61 YTGYNYGNYG YGQGYADYSG QQSTYGKASR GGGNHQNNYQ PY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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