YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: PRMT5
Organism: Homo sapiens
Length: 637 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRMT5.

Description E-value Query
Range
Subject
Range
gi|76626898 - gi|76626898|ref|XP_884043.1| PREDICTED: similar to SKB1 homolog isoform 9 [Bos taurus]
0.0 [4..637] [1..644]
gi|6164706 - gi|6164706|gb|AAF04503.1|AF167573_1 protein methyltransferase [Mus musculus]
0.0 [7..637] [1..631]
gi|109082893 - gi|109082893|ref|XP_001103964.1| PREDICTED: similar to protein arginine methyltransferase 5 isoform ...
0.0 [12..637] [19..644]
gi|54695594 - gi|54695594|gb|AAV38169.1| SKB1 homolog (S. pombe) [synthetic construct]
0.0 [12..637] [12..637]
ANM5_PONAB - Protein arginine N-methyltransferase 5 OS=Pongo abelii GN=PRMT5 PE=2 SV=3
ANM5_PONPY - Protein arginine N-methyltransferase 5 - Pongo pygmaeus (Orangutan)
0.0 [12..637] [12..637]
gi|73962359 - gi|73962359|ref|XP_537366.2| PREDICTED: similar to SKB1 homolog isoform 1 [Canis familiaris]
0.0 [12..637] [12..637]
gi|67970519 - gi|67970519|dbj|BAE01602.1| unnamed protein product [Macaca fascicularis]
0.0 [12..637] [19..644]

Back

Predicted Domain #1
Region A:
Residues: [1-65]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK  60
   61 NRPGP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [66-277]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTRSDLLLSG RDWNTLIVGK LSPWIRPDSK VEKIRRNSEA AMLQELNFGA YLGLPAFLLP  60
   61 LNQEDNTNLA RVLTNHIHTG HHSSMFWMRV PLVAPEDLRD DIIENAPTTH TEEYSGEEKT 120
  121 WMWWHNFRTL CDYSKRIAVA LEIGADLPSN HVIDRWLGEP IKAAILPTSI FLTNKKGFPV 180
  181 LSKMHQRLIF RLLKLEVQFI ITGTNHHSEK EF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [278-637]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSYLQYLEYL SQNRPPPNAY ELFAKGYEDY LQSPLQPLMD NLESQTYEVF EKDPIKYSQY  60
   61 QQAIYKCLLD RVPEEEKDTN VQVLMVLGAG RGPLVNASLR AAKQADRRIK LYAVEKNPNA 120
  121 VVTLENWQFE EWGSQVTVVS SDMREWVAPE KADIIVSELL GSFADNELSP ECLDGAQHFL 180
  181 KDDGVSIPGE YTSFLAPISS SKLYNEVRAC REKDRDPEAQ FEMPYVVRLH NFHQLSAPQP 240
  241 CFTFSHPNRD PMIDNNRYCT LEFPVEVNTV LHGFAGYFET VLYQDITLSI RPETHSPGMF 300
  301 SWFPILFPIK QPITVREGQT ICVRFWRCSN SKKVWYEWAV TAPVCSAIHN PTGRSYTIGL 360
  361 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.154902
Match: 1orhA
Description: Structure of the Predominant Protein Arginine Methyltransferase PRMT1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein-arginine N-methyltransferase activity 5.52520020727046 bayes_pls_golite062009
arginine N-methyltransferase activity 5.52520020727046 bayes_pls_golite062009
protein methyltransferase activity 5.03267617653315 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 4.4632173842967 bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific) 4.42061797259061 bayes_pls_golite062009
histone methyltransferase activity 4.40911163698179 bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity 4.39379274790202 bayes_pls_golite062009
methyltransferase activity 4.15445027778357 bayes_pls_golite062009
N-methyltransferase activity 4.07806017452628 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 4.07153733729662 bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity 3.55785970363721 bayes_pls_golite062009
histone-arginine N-methyltransferase activity 2.86617323549909 bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity 2.80855981068149 bayes_pls_golite062009
transferase activity 2.22303238506686 bayes_pls_golite062009
DNA-methyltransferase activity 2.18991764495147 bayes_pls_golite062009
RNA methyltransferase activity 1.86200407013263 bayes_pls_golite062009
rRNA methyltransferase activity 1.79395300104934 bayes_pls_golite062009
histone methyltransferase activity (H2A-R3 specific) 1.49229188826344 bayes_pls_golite062009
[myelin basic protein]-arginine N-methyltransferase activity 1.49229188826344 bayes_pls_golite062009
histone methyltransferase activity (H3-R2 specific) 1.49229188826344 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
RNA binding 1.10729923226801 bayes_pls_golite062009
binding 0.976078016260105 bayes_pls_golite062009
histone binding 0.964746527369069 bayes_pls_golite062009
transcription regulator activity 0.914549843668268 bayes_pls_golite062009
tRNA methyltransferase activity 0.868107614027708 bayes_pls_golite062009
DNA binding 0.86027591375666 bayes_pls_golite062009
lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 0.858129308056814 bayes_pls_golite062009
mRNA methyltransferase activity 0.73490663449605 bayes_pls_golite062009
mRNA (guanine-N7-)-methyltransferase activity 0.73490663449605 bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity 0.703178429468566 bayes_pls_golite062009
nucleic acid binding 0.616949327277483 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.102141401712309 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.0251895714734512 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle