YRC Public Data Repository - Protein Structure Prediction

Protein:	ACOT8
Organism:	Homo sapiens
Length:	319 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACOT8.

Description	E-value	Query Range	Subject Range
gi\|114682268 - gi\|114682268\|ref\|XP_001158053.1\| PREDICTED: peroxisomal acyl-CoA thioesterase 1 isoform 4 [Pan trogl...	0.0	[1..319]	[1..319]
gi\|2243146 - gi\|2243146\|emb\|CAA60024.1\| thioesterase II [Homo sapiens]	0.0	[1..318]	[1..318]
gi\|60831456 - gi\|60831456\|gb\|AAX36971.1\| peroxisomal acyl-CoA thioesterase [synthetic construct]	0.0	[1..318]	[1..318]
ACOT8_MOUSE - Acyl-coenzyme A thioesterase 8 OS=Mus musculus GN=Acot8 PE=1 SV=1	0.0	[1..319]	[1..320]
gi\|57104252 - gi\|57104252\|ref\|XP_534440.1\| PREDICTED: similar to Peroxisomal acyl-coenzyme A thioester hydrolase 1...	0.0	[1..319]	[1..317]
gi\|50927581, gi\|... - gi\|51036669\|ref\|NP_570112.2\| acyl-CoA thioesterase 8 [Rattus norvegicus], gi\|50927581\|gb\|AAH78751.1\|...	0.0	[1..319]	[1..320]
gi\|109091941 - gi\|109091941\|ref\|XP_001108571.1\| PREDICTED: peroxisomal acyl-CoA thioesterase 1 [Macaca mulatta]	0.0	[1..282]	[1..282]

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Predicted Domain #1

Region A:
Residues: [1-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPQAPEDG QGCGDRGDPP GDLRSVLVTT VLNLEPLDED LFRGRHYWVP AKRLFGGQIV  60
   61 GQALVAAAKS VSEDVHVHSL HCYFVRAGDP KLPVLYQVER TRTGSSFSVR SVKAVQHGKP 120
  121 IFICQASFQQ AQPSPMQHQF SMPTVPPPEE LLDCETLIDQ YLRDPNLQKR YPLALNRIAA 180
  181 QEVPIEIKPV NPSPLSQLQR MEPKQMFWVR ARGYIGEGDM KMHCCVAAYI SDYAFLGTAL 240
  241 LPHQWQHKVH FMVSLDHSMW FHAPFRADHW MLYECESPWA GGSRGLVHGR LWRQDGVLAV 300
  301 TCAQEGVIRV KPQVSESKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.69897
Match:	1c8uA
Description:	Thioesterase II (TesB)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acyl-CoA thioesterase activity	2.60197973503923	bayes_pls_golite062009
CoA hydrolase activity	2.3187640589669	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.14159464719086	bayes_pls_golite062009
thiolester hydrolase activity	1.14125301545576	bayes_pls_golite062009
catalytic activity	0.74605540351792	bayes_pls_golite062009
binding	0.358549779743531	bayes_pls_golite062009
hydrolase activity	0.093543122203219	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: