YRC Public Data Repository - Protein Structure Prediction

Protein:	PUF60
Organism:	Homo sapiens
Length:	559 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUF60.

Description	E-value	Query Range	Subject Range
gi\|109087692 - gi\|109087692\|ref\|XP_001087975.1\| PREDICTED: similar to fuse-binding protein-interacting repressor is...	238.0	[0..1]	[559..1]
PUF60_PONPY - Poly(U)-binding-splicing factor PUF60 - Pongo pygmaeus (Orangutan) PUF60_PONAB - Poly(U)-binding-splicing factor PUF60 OS=Pongo abelii GN=PUF60 PE=2 SV=1	237.0	[0..1]	[559..1]
gi\|73974700 - gi\|73974700\|ref\|XP_848710.1\| PREDICTED: similar to fuse-binding protein-interacting repressor isofor...	237.0	[0..1]	[559..1]
PUF60_MOUSE - Poly(U)-binding-splicing factor PUF60 OS=Mus musculus GN=Puf60 PE=1 SV=2 PUF60_RAT - Poly(U)-binding-splicing factor PUF60 OS=Rattus norvegicus GN=Puf60 PE=2 SV=2	236.0	[0..1]	[559..1]
gi\|6176532 - gi\|6176532\|gb\|AAF05605.1\|AF190744_1 poly-U binding splicing factor PUF60 [Homo sapiens]	236.0	[0..4]	[559..1]
gi\|76677817, gi\|... - gi\|76677817\|ref\|NP_082640.1\| poly-U binding splicing factor 60 isoform a [Mus musculus], gi\|74203983...	234.0	[0..1]	[559..1]

Back

Predicted Domain #1

Region A:
Residues: [1-128]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATATIALQV NGQQGGGSEP AAAAAVVAAG DKWKPPQGTD SIKMENGQST AAKLGLPPLT  60
   61 PEQQEALQKA KKYAMEQSIK SVLVKQTIAH QQQQLTNLQM AAVTMGFGDP LSPLQSMAAQ 120
  121 RQRALAIM

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [129-317]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CRVYVGSIYY ELGEDTIRQA FAPFGPIKSI DMSWDSVTMK HKGFAFVEYE VPEAAQLALE  60
   61 QMNSVMLGGR NIKVGRPSNI GQAQPIIDQL AEEARAFNRI YVASVHQDLS DDDIKSVFEA 120
  121 FGKIKSCTLA RDPTTGKHKG YGFIEYEKAQ SSQDAVSSMN LFDLGGQYLR VGKAVTPPMP 180
  181 LLTPATPGG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.221849
Match:	1pgzA
Description:	Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [318-431]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPPAAAVAAA AATAKITAQE AVAGAAVLGT LGTPGLVSPA LTLAQPLGTL PQAVMAAQAP  60
   61 GVITGVTPAR PPIPVTIPSV GVVNPILASP PTLGLLEPKK EKEEEELFPE SERP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [432-559]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EMLSEQEHMS ISGSSARHMV MQKLLRKQES TVMVLRNMVD PKDIDDDLEG EVTEECGKFG  60
   61 AVNRVIIYQE KQGEEEDAEI IVKIFVEFSI ASETHKAIQA LNGRWFAGRK VVAEVYDQER 120
  121 FDNSDLSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.69897
Match:	1jmtA
Description:	U2AF35 (35 KDa subunit)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits