YRC Public Data Repository - Protein Structure Prediction

Protein:	NECAP1
Organism:	Homo sapiens
Length:	275 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NECAP1.

Description	E-value	Query Range	Subject Range
gi\|22760612 - gi\|22760612\|dbj\|BAC11264.1\| unnamed protein product [Homo sapiens]	0.0	[1..275]	[1..275]
gi\|114643284, gi... - gi\|114643288\|ref\|XP_001166796.1\| PREDICTED: hypothetical protein isoform 1 [Pan troglodytes], gi\|114...	0.0	[1..275]	[1..275]
gi\|55732012 - gi\|55732012\|emb\|CAH92713.1\| hypothetical protein [Pongo abelii] gi\|55732012\|emb\|... - hypothetical protein [Pongo pygmaeus]	0.0	[1..275]	[1..275]
gi\|109095493, gi... - gi\|109095493\|ref\|XP_001113313.1\| PREDICTED: similar to adaptin-ear-binding coat-associated protein 1...	0.0	[1..275]	[1..275]
NECP1_MOUSE - Adaptin ear-binding coat-associated protein 1 OS=Mus musculus GN=Necap1 PE=1 SV=2	0.0	[1..275]	[1..275]
NECP1_BOVIN - Adaptin ear-binding coat-associated protein 1 OS=Bos taurus GN=NECAP1 PE=2 SV=1	0.0	[1..275]	[1..275]
gi\|73997236 - gi\|73997236\|ref\|XP_543832.2\| PREDICTED: similar to adaptin-ear-binding coat-associated protein 1 iso...	0.0	[1..275]	[1..275]

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Predicted Domain #1

Region A:
Residues: [1-138]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATELEYESV LCVKPDVSVY RIPPRASNRG YRASDWKLDQ PDWTGRLRIT SKGKTAYIKL  60
   61 EDKVSGELFA QAPVEQYPGI AVETVTDSSR YFVIRIQDGT GRSAFIGIGF TDRGDAFDFN 120
  121 VSLQDHFKWV KQESEISK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.69897
Match:	1tqzA
Description:	Solution structure of NECAP1 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.71359450116612	bayes_pls_golite062009
clathrin binding	2.40957758416782	bayes_pls_golite062009
protein binding	2.32907126599643	bayes_pls_golite062009
transporter activity	1.28986800087234	bayes_pls_golite062009
phospholipid binding	1.09683218092034	bayes_pls_golite062009
substrate-specific transporter activity	0.79883446648737	bayes_pls_golite062009
protein domain specific binding	0.75677415006638	bayes_pls_golite062009
phosphoinositide binding	0.71817045430443	bayes_pls_golite062009
cytoskeletal protein binding	0.268141992393579	bayes_pls_golite062009
lipid binding	0.179561240451969	bayes_pls_golite062009
pyrophosphatase activity	0.0611639610381174	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0524559849408587	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0498422520006935	bayes_pls_golite062009
actin binding	0.0485598963526399	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [139-275]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESQEMDARPK LDLGFKEGQT IKLCIGNITN KKGGASKPRT ARGGGLSLLP PPPGGKVTIP  60
   61 PPSSSVAISN HVTPPPIPKS NHGGSDADIL LDLDSPAPVT TPAPTPVSVS NDLWGDFSTA 120
  121 SSSVPNQAPQ PSNWVQF

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: