YRC Public Data Repository - Protein Structure Prediction

Protein:	FGF14
Organism:	Homo sapiens
Length:	247 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FGF14.

Description	E-value	Query Range	Subject Range
FGF14_RAT - Fibroblast growth factor 14 OS=Rattus norvegicus GN=Fgf14 PE=2 SV=1 gi\|46575905, gi\|... - gi\|46575905\|ref\|NP_034331.2\| fibroblast growth factor 14 isoform a [Mus musculus], gi\|26326611\|dbj\|B...	1.0E-83	[1..247]	[1..247]
FGF14_MOUSE - Fibroblast growth factor 14 OS=Mus musculus GN=Fgf14 PE=2 SV=1	1.0E-82	[1..247]	[1..247]
gi\|190339590, gi... - gi\|59933268\|ref\|NP_001012382.1\| fibroblast growth factor 14 [Danio rerio], gi\|56201432\|dbj\|BAD72888....	5.0E-79	[1..243]	[1..242]
gi\|6911133, gi\|4... - gi\|6911133\|gb\|AAF31398.1\|AF199611_1 fibroblast growth factor homologous factor 2 isoform 1T+1S' [Gal...	7.0E-78	[1..247]	[1..245]
gi\|60811740, gi\|... - gi\|60825649\|gb\|AAX36728.1\| fibroblast growth factor 13 [synthetic construct], gi\|60811740\|gb\|AAX3618...	2.0E-77	[1..247]	[1..245]
FGF13_PONPY - Fibroblast growth factor 13 - Pongo pygmaeus (Orangutan) HGNC:3670\|MIM:30... - growth factor 13 FGF13 - fibroblast growth factor 13 FGF13_PONAB - Fibroblast growth factor 13 OS=Pongo abelii GN=FGF13 PE=2 SV=1 gi\|114690338 - gi\|114690338\|ref\|XP_001138460.1\| PREDICTED: fibroblast growth factor 13 isoform 1 [Pan troglodytes] CCDS14665.1_1 - null gi\|61364837, gi\|... - gi\|61364837\|gb\|AAX42611.1\| fibroblast growth factor 13 [synthetic construct], gi\|123998141\|gb\|ABM866... gi\|109132467 - gi\|109132467\|ref\|XP_001084335.1\| PREDICTED: fibroblast growth factor 13 isoform 3 [Macaca mulatta]	2.0E-77	[1..247]	[1..245]
gi\|73989458 - gi\|73989458\|ref\|XP_542656.2\| PREDICTED: similar to fibroblast growth factor 14 [Canis familiaris]	3.0E-77	[1..247]	[1..247]

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Predicted Domain #1

Region A:
Residues: [1-247]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLC NGNLVDIFSK VRIFGLKKRR  60
   61 LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN STLFNLIPVG LRVVAIQGVK 120
  121 TGLYIAMNGE GYLYPSELFT PECKFKESVF ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ 180
  181 AMKGNRVKKT KPAAHFLPKP LEVAMYREPS LHDVGETVPK PGVTPSKSTS ASAIMNGGKP 240
  241 VNKSKTT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.69897
Match:	1q1uA
Description:	Crystal structure of human FHF1b (FGF12b)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
receptor binding	4.30358117760805	bayes_pls_golite062009
growth factor activity	3.97089267530575	bayes_pls_golite062009
cytokine activity	3.76931834545338	bayes_pls_golite062009
binding	2.90110516688922	bayes_pls_golite062009
protein binding	1.94397222237906	bayes_pls_golite062009
fibroblast growth factor receptor binding	1.9437092554389	bayes_pls_golite062009
pattern binding	0.839280621598109	bayes_pls_golite062009
interleukin-1 receptor binding	0.8084616632765	bayes_pls_golite062009
glycosaminoglycan binding	0.69866345905635	bayes_pls_golite062009
heparin binding	0.290941670257021	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: