YRC Public Data Repository - Protein Structure Prediction

Protein:	BAG4
Organism:	Homo sapiens
Length:	457 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BAG4.

Description	E-value	Query Range	Subject Range
gi\|70878103 - gi\|70878103\|gb\|EAN91386.1\| trans-sialidase, putative [Trypanosoma cruzi] gi\|71648919 - gi\|71648919\|ref\|XP_813237.1\| trans-sialidase [Trypanosoma cruzi strain CL Brener]	2.0E-35	[1..414]	[692..1104]
gi\|76655892 - gi\|76655892\|ref\|XP_594506.2\| PREDICTED: similar to BAG-family molecular chaperone regulator-4 (BCL2-...	1.0E-31	[1..457]	[89..545]
gi\|39579415, gi\|... - gi\|39579415\|emb\|CAE56721.1\| Hypothetical protein CBG24508 [Caenorhabditis briggsae], gi\|187040086\|em...	7.0E-31	[2..414]	[40..456]
SLP1_CLOTM, SLAP... - (Q06852) Cell surface glycoprotein 1 precursor (Outer layer protein B) (S-layer protein 1), Cell sur...	1.0E-30	[4..408]	[937..1346]
SLAP1_CLOTH - Cell surface glycoprotein 1 OS=Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 ...	1.0E-30	[4..408]	[1543..1952]
gi\|73979313 - gi\|73979313\|ref\|XP_849918.1\| PREDICTED: similar to BAG-family molecular chaperone regulator-4 (BCL2-...	1.0E-30	[1..457]	[1..457]

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Predicted Domain #1

Region A:
Residues: [1-246]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSALRRSGYG PSDGPSYGRY YGPGGGDVPV HPPPPLYPLR PEPPQPPISW RVRGGGPAET  60
   61 TWLGEGGGGD GYYPSGGAWP EPGRAGGSHQ EQPPYPSYNS NYWNSTARSR APYPSTYPVR 120
  121 PELQGQSLNS YTNGAYGPTY PPGPGANTAS YSGAYYAPGY TQTSYSTEVP STYRSSGNSP 180
  181 TPVSRWIYPQ QDCQTEAPPL RGQVPGYPPS QNPGMTLPHY PYGDGNRSVP QSGPTVRPQE 240
  241 DAWASP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [247-366]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAYGMGGRYP WPSSAPSAPP GNLYMTESTS PWPSSGSPQS PPSPPVQQPK DSSYPYSQSD  60
   61 QSMNRHNFPC SVHQYESSGT VNNDDSDLLD SQVQYSAEPQ LYGNATSDHP NNQDQSSSLP 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [367-457]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EECVPSDEST PPSIKKIIHV LEKVQYLEQE VEEFVGKKTD KAYWLLEEML TKELLELDSV  60
   61 ETGGQDSVRQ ARKEAVCKIQ AILEKLEKKG L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.154902
Match:	1m7kA
Description:	Silencer of death domains, Sodd (Bag4)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.46279312857752	bayes_pls_golite062009
protein binding	1.31870344025745	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: