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View Structure Prediction Details

Protein: STAM
Organism: Homo sapiens
Length: 540 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STAM.

Description E-value Query
Range
Subject
Range
gi|114629620 - gi|114629620|ref|XP_001153098.1| PREDICTED: signal transducing adaptor molecule 1 isoform 4 [Pan tro...
2.0E-80 [1..517] [1..517]
STAM1_MOUSE - Signal transducing adapter molecule 1 OS=Mus musculus GN=Stam PE=1 SV=3
6.0E-80 [1..540] [1..548]
gi|197246851, gi... - gi|197246851|gb|AAI68933.1| Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Rattu...
2.0E-79 [1..540] [1..547]
gi|73948986 - gi|73948986|ref|XP_535174.2| PREDICTED: similar to signal transducing adaptor molecule 1 [Canis fami...
4.0E-78 [1..517] [1..515]
gi|21265031 - gi|21265031|ref|NP_005834.3| signal transducing adaptor molecule 2 [Homo sapiens]
8.0E-78 [1..537] [1..523]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLFATNPFD QDVEKATSEM NTAEDWGLIL DICDKVGQSR TGPKDCLRSI MRRVNHKDPH  60
   61 VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSNVLNKG HPKVCEKLKA LMVEWTDEFK 120
  121 NDPQLSLISA MIKNLKEQGV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.30103
Match: 1x5bA
Description: The solution structure of the VHS domain of human Signal transducing adaptor molecule 2
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [141-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFPAIGSQAA EQAKASPALV AKDPGTVANK KEEEDLAKAI ELSLKEQRQQ STTLSTLYPS  60
   61 TSSLLTNHQH 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [211-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGRKVRAIYD FEAAEDNELT FKAGEIITVL DDSDPNWWKG ETHQGIGLFP SNFVTADLTA  60
   61 EPE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 1x2qA
Description: Solution structure of the SH3 domain of the Signal transducing adaptor molecule 2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [274-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKTEKKTVQ FSDDVQVETI EPEPEPAFID EDKMDQLLQM LQSTDPSDDQ PDLPELLHLE  60
   61 AMCHQMGPLI DEKLEDIDRK HSELSELNVK VMEALSL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.98
Match: 2pjwH
Description: No description for 2pjwH was found.

Predicted Domain #5
Region A:
Residues: [371-540]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTKLMNEDPM YSMYAKLQNQ PYYMQSSGVS GSQVYAGPPP SGAYLVAGNA QMSHLQSYSL  60
   61 PPEQLSSLSQ AVVPPSANPA LPSQQTQAAY PNTMVSSVQG NTYPSQAPVY SPPPAATAAA 120
  121 ATADVTLYQN AGPNMPQVPN YNLTSSTLPQ PGGSQQPPQP QQPYSQKALL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.221849
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

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Created and Maintained by: Michael Riffle