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View Structure Prediction Details

Protein: STAM
Organism: Homo sapiens
Length: 540 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STAM.

Description E-value Query
Range
Subject
Range
gi|114629620 - gi|114629620|ref|XP_001153098.1| PREDICTED: signal transducing adaptor molecule 1 isoform 4 [Pan tro...
2.0E-80 [1..517] [1..517]
STAM1_MOUSE - Signal transducing adapter molecule 1 OS=Mus musculus GN=Stam PE=1 SV=3
6.0E-80 [1..540] [1..548]
gi|197246851, gi... - gi|197246851|gb|AAI68933.1| Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [Rattu...
2.0E-79 [1..540] [1..547]
gi|73948986 - gi|73948986|ref|XP_535174.2| PREDICTED: similar to signal transducing adaptor molecule 1 [Canis fami...
4.0E-78 [1..517] [1..515]
gi|21265031 - gi|21265031|ref|NP_005834.3| signal transducing adaptor molecule 2 [Homo sapiens]
8.0E-78 [1..537] [1..523]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLFATNPFD QDVEKATSEM NTAEDWGLIL DICDKVGQSR TGPKDCLRSI MRRVNHKDPH  60
   61 VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSNVLNKG HPKVCEKLKA LMVEWTDEFK 120
  121 NDPQLSLISA MIKNLKEQGV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.30103
Match: 1x5bA
Description: The solution structure of the VHS domain of human Signal transducing adaptor molecule 2
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [141-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFPAIGSQAA EQAKASPALV AKDPGTVANK KEEEDLAKAI ELSLKEQRQQ STTLSTLYPS  60
   61 TSSLLTNHQH 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [211-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGRKVRAIYD FEAAEDNELT FKAGEIITVL DDSDPNWWKG ETHQGIGLFP SNFVTADLTA  60
   61 EPE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 1x2qA
Description: Solution structure of the SH3 domain of the Signal transducing adaptor molecule 2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [274-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKTEKKTVQ FSDDVQVETI EPEPEPAFID EDKMDQLLQM LQSTDPSDDQ PDLPELLHLE  60
   61 AMCHQMGPLI DEKLEDIDRK HSELSELNVK VMEALSL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.98
Match: 2pjwH
Description: No description for 2pjwH was found.

Predicted Domain #5
Region A:
Residues: [371-540]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTKLMNEDPM YSMYAKLQNQ PYYMQSSGVS GSQVYAGPPP SGAYLVAGNA QMSHLQSYSL  60
   61 PPEQLSSLSQ AVVPPSANPA LPSQQTQAAY PNTMVSSVQG NTYPSQAPVY SPPPAATAAA 120
  121 ATADVTLYQN AGPNMPQVPN YNLTSSTLPQ PGGSQQPPQP QQPYSQKALL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.221849
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

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