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View Structure Prediction Details

Protein: EIF3L
Organism: Homo sapiens
Length: 564 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EIF3L.

Description E-value Query
Range
Subject
Range
gi|168985243, gi... - gi|47678403|emb|CAG30322.1| dJ1014D13.1 [Homo sapiens], gi|168985243|emb|CAQ07544.1| eukaryotic tran...
HGNC:18138|Ensem... - translation initiation factor 3, subunit L
gi|208967805, gi... - gi|208967805|dbj|BAG72548.1| eukaryotic translation initiation factor 3, subunit E interacting prote...
0.0 [1..564] [44..607]
EIF3L_MOUSE - Eukaryotic translation initiation factor 3 subunit L OS=Mus musculus GN=Eif3l PE=1 SV=1
0.0 [1..564] [1..564]
gi|149743030 - gi|149743030|ref|XP_001501256.1| PREDICTED: similar to Eukaryotic translation initiation factor 3 su...
gi|73969158 - gi|73969158|ref|XP_850423.1| PREDICTED: similar to Eukaryotic translation initiation factor 3 subuni...
0.0 [1..564] [1..564]
EIF3L_BOVIN - Eukaryotic translation initiation factor 3 subunit L OS=Bos taurus GN=EIF3L PE=2 SV=1
0.0 [1..564] [1..564]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYPADDYES EAAYDPYAYP SDYDMHTGDP KQDLAYERQY EQQTYQVIPE VIKNFIQYFH  60
   61 KTVSDLIDQK VYELQASRVS SDVIDQKVYE IQDIYENSWT KLTERFFKNT PWPEAEAIAP 120
  121 QVGN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.791 0.793 nucleoplasm a.22.1 Histone-fold
View Download 0.658 0.132 nucleoplasm a.24.9 alpha-catenin/vinculin
View Download 0.625 0.003 protein binding a.24.14 FAT domain of focal adhesion kinase
View Download 0.620 N/A N/A a.22.1 Histone-fold
View Download 0.581 N/A N/A a.24.9 alpha-catenin/vinculin

Predicted Domain #2
Region A:
Residues: [125-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAVFLILYKE LYYRHIYAKV SGGPSLEQRF ESYYNYCNLF NYILNADGPA PLELPNQWLW  60
   61 DIIDEFIYQF QSFSQYRCKT AKKSEEEIDF LRS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.704 0.034 nucleolus a.7.1 Spectrin repeat
View Download 0.817 0.034 nucleolus a.7.8 GAT domain
View Download 0.920 0.034 nucleolus a.24.3 Cytochromes
View Download 0.733 0.034 nucleolus a.24.3 Cytochromes
View Download 0.708 0.034 nucleolus a.24.3 Cytochromes

Predicted Domain #3
Region A:
Residues: [218-373]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPKIWNVHSV LNVLHSLVDK SNINRQLEVY TSGGDPESVA GEYGRHSLYK MLGYFSLVGL  60
   61 LRLHSLLGDY YQAIKVLENI ELNKKSMYSR VPECQVTTYY YVGFAYLMMR RYQDAIRVFA 120
  121 NILLYIQRTK SMFQRTTYKY EMINKQNEQM HALLAI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.22
Match: 2hr2A
Description: No description for 2hr2A was found.

Predicted functions:

Term Confidence Notes
binding 2.50062202757362 bayes_pls_golite062009
protein binding 1.72061787550863 bayes_pls_golite062009
nucleic acid binding 1.03214696367403 bayes_pls_golite062009
transcription regulator activity 1.0247488240855 bayes_pls_golite062009
DNA binding 0.812129701902081 bayes_pls_golite062009
transcription factor activity 0.142011117504773 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [374-564]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALTMYPMRID ESIHLQLREK YGDKMLRMQK GDPQVYEELF SYSCPKFLSP VVPNYDNVHP  60
   61 NYHKEPFLQQ LKVFSDEVQQ QAQLSTIRSF LKLYTTMPVA KLAGFLDLTE QEFRIQLLVF 120
  121 KHKMKNLVWT SGISALDGEF QSASEVDFYI DKDMIHIADT KVARRYGDFF IRQIHKFEEL 180
  181 NRTLKKMGQR P

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.576 0.091 nucleolus a.133.1 Phospholipase A2, PLA2
View Download 0.653 0.018 nucleolus f.14.1 Voltage-gated potassium channels
View Download 0.484 0.011 nucleolus a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.649 0.010 nucleolus d.110.2 GAF domain-like
View Download 0.537 0.004 nucleolus a.50.1 Anaphylotoxins (complement system)


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle