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View Structure Prediction Details

Protein: PRDX3
Organism: Homo sapiens
Length: 256 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRDX3.

Description E-value Query
Range
Subject
Range
gi|61366450, gi|... - gi|61366450|gb|AAX42861.1| peroxiredoxin 3 [synthetic construct], gi|61366442|gb|AAX42860.1| peroxir...
2.0E-78 [1..256] [1..256]
PRDX3_PONAB - Thioredoxin-dependent peroxide reductase, mitochondrial OS=Pongo abelii GN=PRDX3 PE=2 SV=1
PRDX3_PONPY - Thioredoxin-dependent peroxide reductase, mitochondrial precursor - Pongo pygmaeus (Orangutan)
3.0E-78 [1..256] [1..256]
gi|14250063 - gi|14250063|gb|AAH08435.1| Peroxiredoxin 3 [Homo sapiens]
4.0E-78 [1..256] [1..256]
gi|109090690 - gi|109090690|ref|XP_001097456.1| PREDICTED: peroxiredoxin 3 isoform 3 [Macaca mulatta]
8.0E-78 [1..256] [1..256]
gi|114690183, gi... - gi|114690185|ref|XP_001142221.1| PREDICTED: similar to Aop1_Human, MER5(Aop1_Mouse)-like protein iso...
1.0E-77 [1..256] [1..256]
PRDX3_BOVIN - Thioredoxin-dependent peroxide reductase, mitochondrial OS=Bos taurus GN=PRDX3 PE=1 SV=2
2.0E-75 [1..256] [1..257]
gi|73998671 - gi|73998671|ref|XP_535031.2| PREDICTED: similar to Thioredoxin-dependent peroxide reductase, mitocho...
6.0E-75 [1..256] [1..257]
gi|11968132, gi|... - gi|4336877|gb|AAD17992.1| PRx III [Rattus norvegicus], gi|11968132|ref|NP_071985.1| peroxiredoxin 3 ...
1.0E-74 [1..256] [1..257]

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Predicted Domain #1
Region A:
Residues: [1-256]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAVGRLLR ASVARHVSAI PWGISATAAL RPAACGRTSL TNLLCSGSSQ AKLFSTSSSC  60
   61 HAPAVTQHAP YFKGTAVVNG EFKDLSLDDF KGKYLVLFFY PLDFTFVCPT EIVAFSDKAN 120
  121 EFHDVNCEVV AVSVDSHFSH LAWINTPRKN GGLGHMNIAL LSDLTKQISR DYGVLLEGSG 180
  181 LALRGLFIID PNGVIKHLSV NDLPVGRSVE ETLRLVKAFQ YVETHGEVCP ANWTPDSPTI 240
  241 KPSPAASKEY FQKVNQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.39794
Match: 1zyeA
Description: Crystal strucutre analysis of Bovine Mitochondrial Peroxiredoxin III
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
alkyl hydroperoxide reductase activity 4.29610283853788 bayes_pls_golite062009
antioxidant activity 3.8464796631544 bayes_pls_golite062009
peroxidase activity 3.43831566988273 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.43831566988273 bayes_pls_golite062009
selenium binding 2.92496040718744 bayes_pls_golite062009
glutathione peroxidase activity 2.56524997297011 bayes_pls_golite062009
transcription regulator activity 2.30799114442278 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 2.23310780102446 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.47769936616412 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
transferase activity 1.26687471229876 bayes_pls_golite062009
binding 1.25802922431343 bayes_pls_golite062009
protein binding 1.18479617596618 bayes_pls_golite062009
molecular transducer activity 1.11518182894524 bayes_pls_golite062009
signal transducer activity 1.11518182894524 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
peptide binding 0.374493676068876 bayes_pls_golite062009
0.359224524631956 bayes_pls_golite062009
NADH dehydrogenase activity 0.23291471505999 bayes_pls_golite062009
copper ion binding 0.178842772364502 bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity 0.16328723676608 bayes_pls_golite062009
NADH dehydrogenase (quinone) activity 0.0434052164026002 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle