YRC Public Data Repository - Protein Structure Prediction

Protein:	IPI:IPI00037070....
Organism:	Homo sapiens
Length:	497 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IPI:IPI00037070.....

Description	E-value	Query Range	Subject Range
gi\|73954621 - gi\|73954621\|ref\|XP_859437.1\| PREDICTED: similar to heat shock protein 8 isoform 3 [Canis familiaris]	0.0	[1..496]	[1..495]
gi\|74220405, gi\|... - gi\|74220405\|dbj\|BAE31427.1\| unnamed protein product [Mus musculus], gi\|74191381\|dbj\|BAE30272.1\| unna...	0.0	[1..496]	[1..495]
gi\|45544523 - gi\|45544523\|dbj\|BAD12572.1\| heat shock protein [Numida meleagris] gi\|50759965 - ref\|XP_429266.1\| PREDICTED: hypothetical protein XP_429266 [Gallus gallus] gi\|118722053, gi... - gi\|118722053\|dbj\|BAF38392.1\| heat shock protein 70kDa [Coturnix japonica], gi\|118197131\|dbj\|BAF37041...	0.0	[1..496]	[1..495]
HSP7C_RAT - Heat shock cognate 71 kDa protein OS=Rattus norvegicus GN=Hspa8 PE=1 SV=1 HSP7C_MOUSE - Heat shock cognate 71 kDa protein OS=Mus musculus GN=Hspa8 PE=1 SV=1 gi\|148234651, gi... - gi\|148234651\|ref\|NP_001091238.1\| hypothetical protein LOC100037033 [Xenopus laevis], gi\|120577579\|gb...	0.0	[1..496]	[1..495]
HSP7C_BOVIN, HS7... - Heat shock cognate 71 kDa protein (Heat shock 70 kDa protein 8) - Bos taurus (Bovine), (P19120) Heat...	0.0	[1..496]	[1..495]

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Predicted Domain #1

Region A:
Residues: [1-497]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA  60
   61 MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR PKVQVEYKGE TKSFYPEEVS 120
  121 SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF NDSQRQATKD AGTIAGLNVL RIINEPTAAA 180
  181 IAYGLDKKVG AERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH 240
  241 FIAEFKRKHK KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA 300
  301 RFEELNADLF RGTLDPVEKA LRDAKLDKSQ IHDIVLVGGS TRIPKIQKLL QDFFNGKELN 360
  361 KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS LGIETAGGVM TVLIKRNTTI 420
  421 PTKQTQTFTT YSDNQPGVLI QVYEGERAMT KDNNLLGKFE LTGIPPAPRG GMPGGFPGGG 480
  481 APPSGGASSG PTIEEVD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1yuwA
Description:	crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	2.80511977200055	bayes_pls_golite062009
binding	1.54134537534661	bayes_pls_golite062009
protein binding	1.16405332128302	bayes_pls_golite062009
kinase activity	0.641356183582417	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.546260119151063	bayes_pls_golite062009
catalytic activity	0.296484721581333	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.296022504929148	bayes_pls_golite062009
structural constituent of cytoskeleton	0.28741807440215	bayes_pls_golite062009
cytoskeletal protein binding	0.0051518674395068	bayes_pls_golite062009
chaperone binding	0.00111313452804307	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: