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View Structure Prediction Details

Protein: BCL2A1
Organism: Homo sapiens
Length: 175 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BCL2A1.

Description E-value Query
Range
Subject
Range
gi|30583807, gi|... - gi|61370603|gb|AAX43523.1| BCL2-related protein A1 [synthetic construct], gi|30583807|gb|AAP36152.1|...
1.0E-55 [1..175] [1..175]
gi|49456879 - gi|49456879|emb|CAG46760.1| BCL2A1 [Homo sapiens]
2.0E-55 [1..175] [1..175]
gi|14165190, gi|... - gi|19173784|ref|NP_596907.1| B-cell leukemia/lymphoma 2 related protein A1d [Rattus norvegicus], gi|...
2.0E-52 [1..174] [1..174]
gi|2822193, gi|1... - gi|6671630|ref|NP_031562.1| B-cell leukemia/lymphoma 2 related protein A1d [Mus musculus], gi|282219...
1.0E-49 [1..172] [1..172]

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Predicted Domain #1
Region A:
Residues: [1-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDCEFGYIY RLAQDYLQCV LQIPQPGSGP SKTSRVLQNV AFSVQKEVEK NLKSCLDNVN  60
   61 VVSVDTARTL FNQVMEKEFE DGIINWGRIV TIFAFEGILI KKLLRQQIAP DVDTYKEISY 120
  121 FVAEFIMNNT GEWIRQNGGW ENGFVKKFEP KSGWMTFLEV TGKICEMLSL LKQYC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.09691
Match: 1f16A
Description: Proapoptotic molecule Bax
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.38505574840555 bayes_pls_golite062009
protein binding 1.99315623629974 bayes_pls_golite062009
protein dimerization activity 1.51982146662542 bayes_pls_golite062009
protein heterodimerization activity 1.41181426913229 bayes_pls_golite062009
BH3 domain binding 1.23056205927884 bayes_pls_golite062009
BH domain binding 0.960001430248934 bayes_pls_golite062009
caspase inhibitor activity 0.65707524975189 bayes_pls_golite062009
protease binding 0.533614085534475 bayes_pls_golite062009
identical protein binding 0.405202123566641 bayes_pls_golite062009
death domain binding 0.352345757127431 bayes_pls_golite062009
caspase regulator activity 0.287831586746878 bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity 0.00601838015364692 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle