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View Structure Prediction Details

Protein: HIST1H1D
Organism: Homo sapiens
Length: 221 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIST1H1D.

Description E-value Query
Range
Subject
Range
gi|70878483 - gi|70878483|gb|EAN91735.1| trans-sialidase, putative [Trypanosoma cruzi]
gi|71649745 - gi|71649745|ref|XP_813586.1| trans-sialidase [Trypanosoma cruzi strain CL Brener]
1.0E-26 [2..219] [950..1168]
gi|3511287, gi|7... - pir||T31670 DNA-directed RNA polymerase (EC 2.7.7.6) II largest chain - Mastigamoeba invertens (frag...
1.0E-24 [4..198] [1496..1686]
gi|116126363, gi... - gi|118786522|ref|XP_315475.3| ENSANGP00000021721 [Anopheles gambiae str. PEST], gi|116126363|gb|EAA1...
5.0E-24 [5..220] [1018..1248]
gi|76639353 - gi|76639353|ref|XP_607274.2| PREDICTED: similar to neurofilament, heavy polypeptide 200kDa isoform 1...
6.0E-23 [4..220] [556..772]
gi|27881490, gi|... - gi|27881490|ref|NP_775080.1| zonadhesin isoform 4 [Homo sapiens], gi|12667416|gb|AAK01434.1|AF332978...
7.0E-23 [2..221] [568..793]

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Predicted Domain #1
Region A:
Residues: [1-117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSETAPLAPT IPAPAEKTPV KKKAKKAGAT AGKRKASGPP VSELITKAVA ASKERSGVSL  60
   61 AALKKALAAA GYDVEKNNSR IKLGLKSLVS KGTLVQTKGT GASGSFKLNK KAASGEG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.221849
Match: 1ghcA
Description: HOMO-AND HETERONUCLEAR TWO-DIMENSIONAL NMR STUDIES OF THE GLOBULAR DOMAIN OF HISTONE H1: FULL ASSIGNMENT, TERTIARY STRUCTURE, AND COMPARISON WITH THE GLOBULAR DOMAIN OF HISTONE H5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.835523092977445 bayes_pls_golite062009
transcription regulator activity 0.4843036104266 bayes_pls_golite062009
nucleic acid binding 0.37117756729668 bayes_pls_golite062009
DNA binding 0.3118855114645 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [118-221]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPKAKKAGAA KPRKPAGAAK KPKKVAGAAT PKKSIKKTPK KVKKPATAAG TKKVAKSAKK  60
   61 VKTPQPKKAA KSPAKAKAPK PKAAKPKSGK PKVTKAKKAA PKKK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.79
Match: 2j63A
Description: No description for 2j63A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle