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View Structure Prediction Details

Protein: SLC17A6
Organism: Homo sapiens
Length: 582 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLC17A6.

Description E-value Query
Range
Subject
Range
VGLU2_RAT - Vesicular glutamate transporter 2 OS=Rattus norvegicus GN=Slc17a6 PE=1 SV=1
5.0E-81 [1..582] [1..582]
gi|188219544, gi... - gi|23468366|gb|AAH38375.1| Solute carrier family 17 (sodium-dependent inorganic phosphate cotranspor...
1.0E-80 [1..582] [1..582]
VGLU2_BOVIN - Vesicular glutamate transporter 2 OS=Bos taurus GN=SLC17A6 PE=2 SV=1
2.0E-80 [1..582] [1..582]
VGL2A_DANRE - Vesicular glutamate transporter 2.1 OS=Danio rerio GN=slc17a6b PE=2 SV=2
5.0E-72 [1..582] [1..584]
VGLU1_XENLA - Vesicular glutamate transporter 1 OS=Xenopus laevis GN=slc17a7 PE=2 SV=1
2.0E-69 [9..576] [1..568]
VGLU1_XENTR - Vesicular glutamate transporter 1 OS=Xenopus tropicalis GN=slc17a7 PE=2 SV=1
1.0E-68 [9..576] [1..568]

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Predicted Domain #1
Region A:
Residues: [1-582]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESVKQRILA PGKEGLKNFA GKSLGQIYRV LEKKQDTGET IELTEDGKPL EVPERKAPLC  60
   61 DCTCFGLPRR YIIAIMSGLG FCISFGIRCN LGVAIVDMVN NSTIHRGGKV IKEKAKFNWD 120
  121 PETVGMIHGS FFWGYIITQI PGGYIASRLA ANRVFGAAIL LTSTLNMLIP SAARVHYGCV 180
  181 IFVRILQGLV EGVTYPACHG IWSKWAPPLE RSRLATTSFC GSYAGAVIAM PLAGILVQYT 240
  241 GWSSVFYVYG SFGMVWYMFW LLVSYESPAK HPTITDEERR YIEESIGESA NLLGAMEKFK 300
  301 TPWRKFFTSM PVYAIIVANF CRSWTFYLLL ISQPAYFEEV FGFEISKVGM LSAVPHLVMT 360
  361 IIVPIGGQIA DFLRSKQILS TTTVRKIMNC GGFGMEATLL LVVGYSHTRG VAISFLVLAV 420
  421 GFSGFAISGF NVNHLDIAPR YASILMGISN GVGTLSGMVC PIIVGAMTKN KSREEWQYVF 480
  481 LIAALVHYGG VIFYAIFASG EKQPWADPEE TSEEKCGFIH EDELDEETGD ITQNYINYGT 540
  541 TKSYGATTQA NGGWPSGWEK KEEFVQGEVQ DSHSYKDRVD YS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.045757
Match: 1pw4A
Description: Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
substrate-specific transmembrane transporter activity 5.46247398538901 bayes_pls_golite062009
ion transmembrane transporter activity 4.58978526526921 bayes_pls_golite062009
cation transmembrane transporter activity 4.31967711223954 bayes_pls_golite062009
transporter activity 4.09176719149278 bayes_pls_golite062009
anion transmembrane transporter activity 3.94605227012838 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
hexose phosphate transmembrane transporter activity 3.0995260802482 bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity 3.0995260802482 bayes_pls_golite062009
sugar:hydrogen symporter activity 2.99050613058546 bayes_pls_golite062009
cation:sugar symporter activity 2.99050613058546 bayes_pls_golite062009
carbohydrate transmembrane transporter activity 2.62141276633776 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 2.52916479889426 bayes_pls_golite062009
sugar transmembrane transporter activity 2.47557586092261 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.15783210522667 bayes_pls_golite062009
solute:hydrogen symporter activity 2.10485633822652 bayes_pls_golite062009
phosphate transmembrane transporter activity 1.78662033436109 bayes_pls_golite062009
monosaccharide transmembrane transporter activity 1.6904339767429 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
binding 1.26757615356623 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
polyol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.812001619402678 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009

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