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View Structure Prediction Details

Protein: gi|7243181
Organism: Homo sapiens
Length: 1093 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7243181.

Description E-value Query
Range
Subject
Range
gi|28972738 - gi|28972738|dbj|BAC65785.1| mKIAA1400 protein [Mus musculus]
0.0 [39..1093] [46..1098]
gi|114596043 - gi|114596043|ref|XP_001134989.1| PREDICTED: protocadherin 10 isoform 3 [Pan troglodytes]
0.0 [56..1093] [3..1040]
gi|168269858 - gi|168269858|dbj|BAG10056.1| protocadherin-10 precursor [synthetic construct]
PCDH10 - protocadherin 10
0.0 [56..1093] [3..1040]
gi|76631686 - gi|76631686|ref|XP_869875.1| PREDICTED: similar to protocadherin 10 isoform 2 [Bos taurus]
0.0 [56..1093] [3..1039]
gi|14210853, gi|... - gi|47551309|ref|NP_999837.1| protocadherin 10 [Gallus gallus], gi|14210853|gb|AAK57196.1|AF334802_1 ...
0.0 [56..1093] [3..1030]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKRSKIFKDR KPQEPPRSAL LFVFFQIFFC FVVVGEVIGW LTGCGKLLPF LLEMIVLLLF  60
   61 ALLWMVEGVF SQLHYTVQEE QEHGTFVGNI AEDLGLDITK LSARGFQTVP NSRTPYLDLN 120
  121 LETGVLYVNE KIDREQICKQ SPSCVLHLEV FLENPLELFQ VEIEVLDIND NPPSFPEPDL 180
  181 TVEISESATP 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.522879
Match: 1wuzA
Description: Structure of EC1 domain of CNR
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [191-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTRFPLESAF DPDVGTNSLR DYEITPNSYF SLDVQTQGDG NRFAELVLEK PLDREQQAVH  60
   61 RYVLTAVDGG GGGGVGEGGG GGGGAGLPPQ QQRTGTALLT IRVLDSNDNV PAFDQP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.522879
Match: 2a62A
Description: No description for 2a62A was found.

Predicted Domain #3
Region A:
Residues: [307-822]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VYTVSLPENS PPGTLVIQLN ATDPDEGQNG EVVYSFSSHI SPRARELFGL SPRTGRLEVS  60
   61 GELDYEESPV YQVYVQAKDL GPNAVPAHCK VLVRVLDAND NAPEISFSTV KEAVSEGAAP 120
  121 GTVVALFSVT DRDSEENGQV QCELLGDVPF RLKSSFKNYY TIVTEAPLDR EAGDSYTLTV 180
  181 VARDRGEPAL STSKSIQVQV SDVNDNAPRF SQPVYDVYVT ENNVPGAYIY AVSATDRDEG 240
  241 ANAQLAYSIL ECQIQGMSVF TYVSINSENG YLYALRSFDY EQLKDFSFQV EARDAGSPQA 300
  301 LAGNATVNIL IVDQNDNAPA IVAPLPGRNG TPAREVLPRS AEPGYLLTRV AAVDADDGEN 360
  361 ARLTYSIVRG NEMNLFRMDW RTGELRTARR VPAKRDPQRP YELVIEVRDH GQPPLSSTAT 420
  421 LVVQLVDGAV EPQGGGGSGG GGSGEHQRPS RSGGGETSLD LTLILIIALG SVSFIFLLAM 480
  481 IVLAVRCQKE KKLNIYTCLA SDCCLCCCCC GGGGST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 74.09691
Match: 1q55A
Description: W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [823-891]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CCGRQARARK KKLSKSDIML VQSSNVPSNP AQVPIEESGG FGSHHHNQNY CYQVCLTPES  60
   61 AKTDLMFLK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [892-1093]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PCSPSRSTDT EHNPCGAIVT GYTDQQPDII SNGSILSNET KHQRAELSYL VDRPRRVNSS  60
   61 AFQEADIVSS KDSGHGDSEQ GDSDHDATNR AQSAGMDLFS NCTEECKALG HSDRCWMPSF 120
  121 VPSDGRQAAD YRSNLHVPGM DSVPDTEVFE TPEAQPGAER SFSTFGKEKA LHSTLERKEL 180
  181 DGLLTNTRAP YKPPYLTRKR IC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle