YRC Public Data Repository - Protein Structure Prediction

Protein:	EIF2B2
Organism:	Homo sapiens
Length:	351 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EIF2B2.

Description	E-value	Query Range	Subject Range
gi\|123995737 - gi\|123995737\|gb\|ABM85470.1\| eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa [synt... gi\|13111985, gi\|... - gi\|13111985\|gb\|AAH03165.1\| Eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa [Homo ...	0.0	[1..351]	[1..351]
gi\|114653985, gi... - gi\|55641071\|ref\|XP_510071.1\| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes], gi\|1146539...	0.0	[1..351]	[1..351]
gi\|109084338, gi... - gi\|109084338\|ref\|XP_001096586.1\| PREDICTED: eukaryotic translation initiation factor 2B, subunit 2 b...	0.0	[1..351]	[1..351]
EI2BB_MOUSE - Translation initiation factor eIF-2B subunit beta OS=Mus musculus GN=Eif2b2 PE=1 SV=1	0.0	[1..351]	[1..351]
EI2BB_BOVIN - Translation initiation factor eIF-2B subunit beta OS=Bos taurus GN=EIF2B2 PE=2 SV=1	0.0	[1..351]	[1..351]
gi\|47683035, gi\|... - gi\|47683035\|gb\|AAH70506.1\| Eukaryotic translation initiation factor 2B, subunit 2 beta [Rattus norve...	0.0	[1..351]	[1..351]
EI2BB_RABIT - Translation initiation factor eIF-2B subunit beta OS=Oryctolagus cuniculus GN=EIF2B2 PE=1 SV=1	0.0	[1..351]	[1..351]

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Predicted Domain #1

Region A:
Residues: [1-351]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGSAAKGSE LSERIESFVE TLKRGGGPRS SEEMARETLG LLRQIITDHR WSNAGELMEL  60
   61 IRREGRRMTA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS DESDQQESLH KLLTSGGLNE 120
  121 DFSFHYAQLQ SNIIEAINEL LVELEGTMEN IAAQALEHIH SNEVIMTIGF SRTVEAFLKE 180
  181 AARKRKFHVI VAECAPFCQG HEMAVNLSKA GIETTVMTDA AIFAVMSRVN KVIIGTKTIL 240
  241 ANGALRAVTG THTLALAAKH HSTPLIVCAP MFKLSPQFPN EEDSFHKFVA PEEVLPFTEG 300
  301 DILEKVSVHC PVFDYVPPEL ITLFISNIGG NAPSYIYRLM SELYHPDDHV L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	89.221849
Match:	1t9kA
Description:	X-ray crystal structure of aIF-2B alpha subunit-related translation initiation factor [Thermotoga maritima]
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	10.1099993541596	bayes_pls_golite062009
translation regulator activity	5.74669335554405	bayes_pls_golite062009
nucleic acid binding	2.17718456512191	bayes_pls_golite062009
transcription regulator activity	1.9283980201455	bayes_pls_golite062009
DNA binding	1.55389679363348	bayes_pls_golite062009
binding	1.53908996868286	bayes_pls_golite062009
catalytic activity	1.31732715713197	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.09424756417577	bayes_pls_golite062009
transcription factor activity	0.995059566132783	bayes_pls_golite062009
CoA-transferase activity	0.0320953696548698	bayes_pls_golite062009
protein binding	0.0293610121675921	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: