YRC Public Data Repository - Protein Structure Prediction

Protein:	FPGS
Organism:	Homo sapiens
Length:	587 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FPGS.

Description	E-value	Query Range	Subject Range
gi\|39992602, gi\|... - ref\|NP_004948.3\| folylpolyglutamate synthase [Homo sapiens], gi\|39992602\|gb\|AAH64393.1\| Folylpolygl...	0.0	[1..587]	[1..587]
gi\|2137812, gi\|1... - gi\|33469107\|ref\|NP_034366.1\| folylpolyglutamyl synthetase [Mus musculus], pir\|\|S65755 tetrahydrofoly...	0.0	[1..587]	[1..587]
gi\|149039000, gi... - gi\|226342937\|ref\|NP_001139597.2\| folylpolyglutamate synthase [Rattus norvegicus], gi\|149039000\|gb\|ED...	0.0	[1..587]	[1..587]
FOLC_CRIGR - Folylpolyglutamate synthase, mitochondrial OS=Cricetulus griseus GN=FPGS PE=2 SV=1	0.0	[1..587]	[1..587]
gi\|73968184 - gi\|73968184\|ref\|XP_851481.1\| PREDICTED: similar to Folylpolyglutamate synthase, mitochondrial precur...	0.0	[1..587]	[1..588]

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Predicted Domain #1

Region A:
Residues: [1-587]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRARSHLRA ALFLAAASAR GITTQVAARR GLSAWPVPQE PSMEYQDAVR MLNTLQTNAG  60
   61 YLEQVKRQRG DPQTQLEAME LYLARSGLQV EDLDRLNIIH VTGTKGKGST CAFTECILRS 120
  121 YGLKTGFFSS PHLVQVRERI RINGQPISPE LFTKYFWRLY HRLEETKDGS CVSMPPYFRF 180
  181 LTLMAFHVFL QEKVDLAVVE VGIGGAYDCT NIIRKPVVCG VSSLGIDHTS LLGDTVEKIA 240
  241 WQKGGIFKQG VPAFTVLQPE GPLAVLRDRA QQISCPLYLC PMLEALEEGG PPLTLGLEGE 300
  301 HQRSNAALAL QLAHCWLQRQ DRHGAGEPKA SRPGLLWQLP LAPVFQPTSH MRLGLRNTEW 360
  361 PGRTQVLRRG PLTWYLDGAH TASSAQACVR WFRQALQGRE RPSGGPEVRV LLFNATGDRD 420
  421 PAALLKLLQP CQFDYAVFCP NLTEVSSTGN ADQQNFTVTL DQVLLRCLEH QQHWNHLDEE 480
  481 QASPDLWSAP SPEPGGSASL LLAPHPPHTC SASSLVFSCI SHALQWISQG RDPIFQPPSP 540
  541 PKGLLTHPVA HSGASILREA AAIHVLVTGS LHLVGGVLKL LEPALSQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	60.39794
Match:	1o5zA
Description:	Crystal structure of Folylpolyglutamate synthase (TM0166) from Thermotoga maritima at 2.10 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acid-amino acid ligase activity	4.03401034724886	bayes_pls_golite062009
tetrahydrofolylpolyglutamate synthase activity	3.94486215528378	bayes_pls_golite062009
ligase activity	3.80574681739772	bayes_pls_golite062009
catalytic activity	2.66037860982128	bayes_pls_golite062009
dihydrofolate synthase activity	2.50201834836027	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	1.96801058335544	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: