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View Structure Prediction Details

Protein: PCNA
Organism: Homo sapiens
Length: 261 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PCNA.

Description E-value Query
Range
Subject
Range
gi|73991708 - gi|73991708|ref|XP_534355.2| PREDICTED: similar to proliferating cell nuclear antigen [Canis familia...
1.0E-99 [1..261] [206..466]
gi|53600 - gi|53600|emb|CAA37243.1| unnamed protein product [Mus musculus]
3.0E-92 [1..261] [1..261]
PCNA_BOVIN - Proliferating cell nuclear antigen OS=Bos taurus GN=PCNA PE=2 SV=1
6.0E-92 [1..261] [1..261]
gi|61368335, gi|... - gi|61369547|gb|AAX43349.1| proliferating cell nuclear antigen [synthetic construct], gi|61368335|gb|...
8.0E-92 [1..261] [1..261]
PCNA_RAT - Proliferating cell nuclear antigen OS=Rattus norvegicus GN=Pcna PE=1 SV=1
8.0E-92 [1..261] [1..261]
PCNA_CRIGR - Proliferating cell nuclear antigen OS=Cricetulus griseus GN=PCNA PE=1 SV=1
2.0E-91 [1..261] [1..261]
gi|2914387, gi|2... - gi|2914387|pdb|1AXC|E Chain E, Human Pcna, gi|2914385|pdb|1AXC|C Chain C, Human Pcna
5.0E-91 [2..261] [2..261]

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Predicted Domain #1
Region A:
Residues: [1-261]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLRSEGFDTY  60
   61 RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD 120
  121 LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI 180
  181 KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLNFFTKATP LSSTVTLSMS ADVPLVVEYK 240
  241 IADMGHLKYY LAPKIEDEEG S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.30103
Match: 1axcA
Description: Prolifirating cell nuclear antigen (PCNA)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA polymerase processivity factor activity 9.9878881203193 bayes_pls_golite062009
DNA-directed DNA polymerase activity 5.01426276108174 bayes_pls_golite062009
DNA polymerase activity 4.9656505576274 bayes_pls_golite062009
nucleotidyltransferase activity 3.23598180825386 bayes_pls_golite062009
mismatched DNA binding 2.75713709757781 bayes_pls_golite062009
DNA insertion or deletion binding 2.48680473192192 bayes_pls_golite062009
nucleic acid binding 2.32553487472442 bayes_pls_golite062009
DNA binding 2.24518789437215 bayes_pls_golite062009
binding 1.88302251910664 bayes_pls_golite062009
dinucleotide insertion or deletion binding 1.68153838099672 bayes_pls_golite062009
mismatch repair complex binding 1.6296761041903 bayes_pls_golite062009
MutLalpha complex binding 1.21442872292245 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.14392061238362 bayes_pls_golite062009
structure-specific DNA binding 0.785542777582287 bayes_pls_golite062009
catalytic activity 0.48077242755678 bayes_pls_golite062009
double-stranded DNA binding 0.457118392479642 bayes_pls_golite062009
protein binding 0.452894757163315 bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity 0.408841404605319 bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity 0.387975438046246 bayes_pls_golite062009
transferase activity 0.345371754708312 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle