YRC Public Data Repository - Protein Structure Prediction

Protein:	FNTB
Organism:	Homo sapiens
Length:	437 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FNTB.

Description	E-value	Query Range	Subject Range
gi\|28207887 - gi\|28207887\|emb\|CAD62597.1\| unnamed protein product [Homo sapiens]	0.0	[1..437]	[4..440]
CCDS9769.1_1 - null gi\|109083939 - gi\|109083939\|ref\|XP_001103300.1\| PREDICTED: similar to farnesyltransferase, CAAX box, beta isoform 2...	0.0	[1..437]	[1..437]
gi\|56553908 - gi\|56553908\|pdb\|1TN8\|B Chain B, Protein Farnesyltransferase Complexed With A H-Ras Peptide Substrate... FNTB_RAT - Protein farnesyltransferase subunit beta OS=Rattus norvegicus GN=Fntb PE=1 SV=1	0.0	[1..437]	[1..437]
FNTB_MOUSE - Protein farnesyltransferase subunit beta OS=Mus musculus GN=Fntb PE=1 SV=1	0.0	[1..437]	[1..437]
FNTB_BOVIN - Protein farnesyltransferase subunit beta OS=Bos taurus GN=FNTB PE=2 SV=1	0.0	[1..437]	[1..437]

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Predicted Domain #1

Region A:
Residues: [1-437]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASPSSFTYY CPPSSSPVWS EPLYSLRPEH ARERLQDDSV ETVTSIEQAK VEEKIQEVFS  60
   61 SYKFNHLVPR LVLQREKHFH YLKRGLRQLT DAYECLDASR PWLCYWILHS LELLDEPIPQ 120
  121 IVATDVCQFL ELCQSPEGGF GGGPGQYPHL APTYAAVNAL CIIGTEEAYD IINREKLLQY 180
  181 LYSLKQPDGS FLMHVGGEVD VRSAYCAASV ASLTNIITPD LFEGTAEWIA RCQNWEGGIG 240
  241 GVPGMEAHGG YTFCGLAALV ILKRERSLNL KSLLQWVTSR QMRFEGGFQG RCNKLVDGCY 300
  301 SFWQAGLLPL LHRALHAQGD PALSMSHWMF HQQALQEYIL MCCQCPAGGL LDKPGKSRDF 360
  361 YHTCYCLSGL SIAQHFGSGA MLHDVVLGVP ENALQPTHPV YNIGPDKVIQ ATTYFLQKPV 420
  421 PGFEELKDET SAEPATD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	146.0
Match:	1jcqB
Description:	Protein farnesyltransferase, beta-subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein prenyltransferase activity	13.7736019666673	bayes_pls_golite062009
protein geranylgeranyltransferase activity	12.9757276506747	bayes_pls_golite062009
Rab geranylgeranyltransferase activity	12.8088011327065	bayes_pls_golite062009
prenyltransferase activity	11.6786310564018	bayes_pls_golite062009
CAAX-protein geranylgeranyltransferase activity	10.5569796788906	bayes_pls_golite062009
protein farnesyltransferase activity	10.5544498824038	bayes_pls_golite062009
binding	1.68564752993879	bayes_pls_golite062009
protein binding	1.45455287827127	bayes_pls_golite062009
transferase activity	1.0950430724883	bayes_pls_golite062009
catalytic activity	0.497699107100544	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: