YRC Public Data Repository - Protein Structure Prediction

Protein:	CSTF3
Organism:	Homo sapiens
Length:	717 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CSTF3.

Description	E-value	Query Range	Subject Range
CSTF3_PONPY - Cleavage stimulation factor 77 kDa subunit - Pongo pygmaeus (Orangutan) CSTF3_PONAB - Cleavage stimulation factor subunit 3 OS=Pongo abelii GN=CSTF3 PE=2 SV=1	5.0E-77	[1..717]	[1..717]
gi\|114636834 - gi\|114636834\|ref\|XP_001143931.1\| PREDICTED: cleavage stimulation factor subunit 3 isoform 2 [Pan tro...	6.0E-77	[8..717]	[40..749]
gi\|73982208 - gi\|73982208\|ref\|XP_533159.2\| PREDICTED: similar to cleavage stimulation factor subunit 3 isoform 1 [...	1.0E-76	[1..717]	[1..717]
tr\|G3GYX4\|G3GYX4... - Cleavage stimulation factor 77 kDa subunit OS=Cricetulus griseus GN=I79_003023 PE=4 SV=1 gi\|109470315, gi... - gi\|149022800\|gb\|EDL79694.1\| cleavage stimulation factor, 3' pre-RNA, subunit 3 (predicted), isoform ... CSTF3_MOUSE - Cleavage stimulation factor subunit 3 OS=Mus musculus GN=Cstf3 PE=1 SV=1	6.0E-76	[1..717]	[1..717]
gi\|15131402 - gi\|15131402\|emb\|CAC48252.1\| dJ85M6.1 (cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kD) [Hom...	3.0E-75	[10..717]	[1..708]
gi\|60302784, gi\|... - gi\|60302784\|ref\|NP_001012586.1\| cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa [Gallus ga...	8.0E-75	[5..717]	[6..718]
gi\|109468513 - gi\|109468513\|ref\|XP_342478.3\| PREDICTED: similar to cleavage stimulation factor subunit 3 isoform 1 ...	1.0E-74	[1..717]	[1..717]
gi\|73476127 - gi\|73476127\|emb\|CAJ21197.1\| cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa [Xenopus laevi...	4.0E-73	[7..717]	[9..719]
gi\|38649389, gi\|... - gi\|45361053\|ref\|NP_989162.1\| cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa [Xenopus (Sil...	2.0E-72	[7..717]	[8..718]

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Predicted Domain #1

Region A:
Residues: [1-573]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGDGATEQA AEYVPEKVKK AEKKLEENPY DLDAWSILIR EAQNQPIDKA RKTYERLVAQ  60
   61 FPSSGRFWKL YIEAEIKAKN YDKVEKLFQR CLMKVLHIDL WKCYLSYVRE TKGKLPSYKE 120
  121 KMAQAYDFAL DKIGMEIMSY QIWVDYINFL KGVEAVGSYA ENQRITAVRR VYQRGCVNPM 180
  181 INIEQLWRDY NKYEEGINIH LAKKMIEDRS RDYMNARRVA KEYETVMKGL DRNAPSVPPQ 240
  241 NTPQEAQQVD MWKKYIQWEK SNPLRTEDQT LITKRVMFAY EQCLLVLGHH PDIWYEAAQY 300
  301 LEQSSKLLAE KGDMNNAKLF SDEAANIYER AISTLLKKNM LLYFAYADYE ESRMKYEKVH 360
  361 SIYNRLLAIE DIDPTLVYIQ YMKFARRAEG IKSGRMIFKK AREDTRTRHH VYVTAALMEY 420
  421 YCSKDKSVAF KIFELGLKKY GDIPEYVLAY IDYLSHLNED NNTRVLFERV LTSGSLPPEK 480
  481 SGEIWARFLA FESNIGDLAS ILKVEKRRFT AFKEEYEGKE TALLVDRYKF MDLYPCSASE 540
  541 LKALGYKDVS RAKLAAIIPD PVVAPSIVPV LKD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.522879
Match:	2ooeA
Description:	No description for 2ooeA was found.

Predicted functions:

Term	Confidence	Notes
binding	2.12690485191789	bayes_pls_golite062009
protein binding	1.65083457326273	bayes_pls_golite062009
transcription regulator activity	1.26149030245805	bayes_pls_golite062009
RNA binding	1.1868411700113	bayes_pls_golite062009
DNA binding	0.9531600253493	bayes_pls_golite062009
nucleic acid binding	0.93037889019021	bayes_pls_golite062009
transcription factor activity	0.374364600772076	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [574-717]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVDRKPEYPK PDTQQMIPFQ PRHLAPPGLH PVPGGVFPVP PAAVVLMKLL PPPICFQGPF  60
   61 VQVDELMEIF RRCKIPNTVE EAVRIITGGA PELAVEGNGP VESNAVLTKA VKRPNEDSDE 120
  121 DEEKGAVVPP VHDIYRARQQ KRIR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: