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View Structure Prediction Details

Protein: ADK
Organism: Homo sapiens
Length: 362 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADK.

Description E-value Query
Range
Subject
Range
ADK_RAT - (Q64640) Adenosine kinase (EC 2.7.1.20) (AK) (Adenosine 5'-phosphotransferase)
1.0E-73 [3..362] [2..361]
gi|114631311 - gi|114631311|ref|XP_001148292.1| PREDICTED: adenosine kinase isoform 4 [Pan troglodytes]
2.0E-73 [1..362] [1..362]
gi|109089261 - gi|109089261|ref|XP_001098242.1| PREDICTED: similar to adenosine kinase isoform b isoform 1 [Macaca ...
CCDS7343.1_1 - null
9.0E-73 [1..362] [1..362]
gi|25320034 - gi|25320034|pir||JC7368 adenosine kinase (EC 2.7.1.20) - Chinese hamster
3.0E-72 [3..362] [2..361]
ADK_MOUSE - Adenosine kinase OS=Mus musculus GN=Adk PE=1 SV=2
1.0E-71 [3..362] [2..361]
gi|57085123 - gi|57085123|ref|XP_536396.1| PREDICTED: similar to adenosine kinase isoform b isoform 1 [Canis famil...
4.0E-71 [1..362] [1..362]
gi|39645529, gi|... - gi|47086461|ref|NP_997956.1| adenosine kinase a [Danio rerio], gi|39645529|gb|AAH63961.1| Adenosine ...
1.0E-69 [4..362] [2..359]

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Predicted Domain #1
Region A:
Residues: [1-362]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAEEEPKP KKLKVEAPQA LRENILFGMG NPLLDISAVV DKDFLDKYSL KPNDQILAED  60
   61 KHKELFDELV KKFKVEYHAG GSTQNSIKVA QWMIQQPHKA ATFFGCIGID KFGEILKRKA 120
  121 AEAHVDAHYY EQNEQPTGTC AACITGDNRS LIANLAAANC YKKEKHLDLE KNWMLVEKAR 180
  181 VCYIAGFFLT VSPESVLKVA HHASENNRIF TLNLSAPFIS QFYKESLMKV MPYVDILFGN 240
  241 ETEAATFARE QGFETKDIKE IAKKTQALPK MNSKRQRIVI FTQGRDDTIM ATESEVTAFA 300
  301 VLDQDQKEII DTNGAGDAFV GGFLSQLVSD KPLTECIRAG HYAASIIIRR TGCTFPEKPD 360
  361 FH

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Detection Method: PSI-BLAST
Confidence: 70.045757
Match: 1bx4A
Description: Adenosine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribokinase activity 4.13972810632318 bayes_pls_golite062009
carbohydrate kinase activity 3.53872211951287 bayes_pls_golite062009
kinase activity 2.62513857264891 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.27980720248925 bayes_pls_golite062009
transferase activity 2.15883296431019 bayes_pls_golite062009
phosphofructokinase activity 1.98381934960918 bayes_pls_golite062009
catalytic activity 1.74474587246986 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.25475125578564 bayes_pls_golite062009
binding 1.2232081857689 bayes_pls_golite062009
nucleic acid binding 0.7129235268659 bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor 0.674859721488821 bayes_pls_golite062009
nucleoside kinase activity 0.64600290675128 bayes_pls_golite062009
DNA binding 0.539646335329826 bayes_pls_golite062009
transcription regulator activity 0.513845040759165 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.26945430533876 bayes_pls_golite062009
protein binding 0.0174536862883089 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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