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View Structure Prediction Details

Protein: STIP1
Organism: Homo sapiens
Length: 543 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STIP1.

Description E-value Query
Range
Subject
Range
gi|33640682, gi|... - gi|33862569|ref|NP_894129.1| TPR repeat-containing protein [Prochlorococcus marinus str. MIT 9313], ...
5.0E-70 [3..538] [502..1020]
gi|113475191, gi... - gi|113475191|ref|YP_721252.1| glycosyl transferase family protein [Trichodesmium erythraeum IMS101],...
6.0E-70 [4..543] [80..602]
gi|73670079, gi|... - gi|73670079|ref|YP_306094.1| TPR repeat-containing protein [Methanosarcina barkeri str. Fusaro], gi|...
7.0E-65 [2..536] [354..905]
gi|126179259, gi... - gi|126179259|ref|YP_001047224.1| TPR repeat-containing protein [Methanoculleus marisnigri JR1], gi|1...
2.0E-57 [3..534] [489..1035]
gi|21228822, gi|... - gi|21228822|ref|NP_634744.1| hypothetical protein MM_2720 [Methanosarcina mazei Go1], gi|20907343|gb...
3.0E-57 [4..530] [401..946]
gi|118385554 - gi|118385554|ref|XP_001025906.1| TPR Domain containing protein [Tetrahymena thermophila]
gi|89307673, gi|... - gi|89307673|gb|EAS05661.1| TPR Domain containing protein [Tetrahymena thermophila SB210], gi|1183855...
9.0E-57 [7..533] [477..1019]

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Predicted Domain #1
Region A:
Residues: [1-122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAK KGDYQKAYED  60
   61 GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK HEANNPQLKE GLQNMEARLA 120
  121 ER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.09691
Match: 1elwA
Description: Hop
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.12690485191789 bayes_pls_golite062009
protein binding 1.37554190575452 bayes_pls_golite062009
heat shock protein binding 1.35268080101836 bayes_pls_golite062009
unfolded protein binding 1.03065657981002 bayes_pls_golite062009
chaperone binding 0.677143111475679 bayes_pls_golite062009
nucleic acid binding 0.41706917101675 bayes_pls_golite062009
transcription regulator activity 0.194719472400022 bayes_pls_golite062009
DNA binding 0.17736976899009 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [123-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFMNPFNMPN LYQKLESDPR TRTLLSDPTY RELIEQLRNK PSDLGTKLQD PRIMTTLSVL  60
   61 LGVDLGSMDE EEEIATPPPP PPPKKETKPE PMEEDLPENK KQALKEKELG NDAYKKKDFD 120
  121 TALKHYDKAK ELDPTNMTYI TNQAAVYFEK GDYNKCRELC EKAIEVGREN REDYRQIAKA 180
  181 YARIGNSYFK EEKYKDAIHF YNKSLA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.43
Match: 2q7fA
Description: No description for 2q7fA was found.

Predicted Domain #3
Region A:
Residues: [329-426]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHRTPDVLKK CQQAEKILKE QERLAYINPD LALEEKNKGN ECFQKGDYPQ AMKHYTEAIK  60
   61 RNPKDAKLYS NRAACYTKLL EFQLALKDCE ECIQLEPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1hh8A
Description: Neutrophil cytosolic factor 2 (NCF-2, p67-phox)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.12690485191789 bayes_pls_golite062009
protein binding 1.37554190575452 bayes_pls_golite062009
heat shock protein binding 1.35268080101836 bayes_pls_golite062009
unfolded protein binding 1.03065657981002 bayes_pls_golite062009
chaperone binding 0.677143111475679 bayes_pls_golite062009
nucleic acid binding 0.41706917101675 bayes_pls_golite062009
transcription regulator activity 0.194719472400022 bayes_pls_golite062009
DNA binding 0.17736976899009 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [427-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FIKGYTRKAA ALEAMKDYTK AMDVYQKALD LDSSCKEAAD GYQRCMMAQY NRHDSPEDVK  60
   61 RRAMADPEVQ QIMSDPAMRL ILEQMQKDPQ ALSEHLKNPV IAQKIQKLMD VGLIAIR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1zbpA
Description: Crystal Structure of the Hypothetical protein VPA1032 from Vibrio parahaemolyticus, Northeast Structural Genomics Target VpR44
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle