YRC Public Data Repository - Protein Structure Prediction

Protein:	GCLC
Organism:	Homo sapiens
Length:	637 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCLC.

Description	E-value	Query Range	Subject Range
gi\|109071531, gi... - gi\|109071533\|ref\|XP_001108943.1\| PREDICTED: glutamate-cysteine ligase, catalytic subunit isoform 3 [... CCDS4952.1_1 - null	0.0	[1..637]	[1..637]
gi\|114607910, gi... - gi\|114607912\|ref\|XP_001155930.1\| PREDICTED: glutamate-cysteine ligase, catalytic subunit isoform 5 [...	0.0	[1..637]	[1..637]
GSH1_MOUSE - Glutamate--cysteine ligase catalytic subunit OS=Mus musculus GN=Gclc PE=1 SV=4	0.0	[1..636]	[1..636]
GSH1_RAT - Glutamate--cysteine ligase catalytic subunit OS=Rattus norvegicus GN=Gclc PE=1 SV=2	0.0	[1..637]	[1..637]
gi\|73973063 - gi\|73973063\|ref\|XP_852845.1\| PREDICTED: similar to Glutamate--cysteine ligase catalytic subunit (Gam...	0.0	[1..637]	[1..637]
gi\|76649807 - gi\|76649807\|ref\|XP_870808.1\| PREDICTED: similar to gamma-glutamylcysteine synthetase isoform 2 [Bos ...	0.0	[1..636]	[1..636]

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Predicted Domain #1

Region A:
Residues: [1-637]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLLSQGSPL SWEETKRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH  60
   61 ENKKVRLVLS GEKVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV 120
  121 EANMRKRRKE ATSILEENQA LCTITSFPRL GCPGFTLPEV KPNPVEGGAS KSLFFPDEAI 180
  181 NKHPRFSTLT RNIRHRRGEK VVINVPIFKD KNTPSPFIET FTEDDEASRA SKPDHIYMDA 240
  241 MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI 300
  301 SASVDDRTRE ERGLEPLKNN NYRISKSRYD SIDSYLSKCG EKYNDIDLTI DKEIYEQLLQ 360
  361 EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI 420
  421 GWRVEFRPME VQLTDFENSA YVVFVVLLTR VILSYKLDFL IPLSKVDENM KVAQKRDAVL 480
  481 QGMFYFRKDI CKGGNAVVDG CGKAQNSTEL AAEEYTLMSI DTIINGKEGV FPGLIPILNS 540
  541 YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEMNYS 600
  601 LILKCNQIAN ELCECPELLG SAFRKVKYSG SKTDSSN

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.69
Match:	2gwcA
Description:	No description for 2gwcA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits