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View Structure Prediction Details

Protein: AXIN1
Organism: Homo sapiens
Length: 862 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AXIN1.

Description E-value Query
Range
Subject
Range
gi|66350811, gi|... - gi|66350948|emb|CAI95600.1| axin 1 [Homo sapiens], gi|66350811|emb|CAI95589.1| axin 1 [Homo sapiens]
0.0 [1..862] [50..911]
gi|149269133, gi... - gi|82993040|ref|XP_920000.1| PREDICTED: similar to Axin-1 (Axis inhibition protein 1) (Fused protein...
0.0 [1..862] [131..993]
gi|73959219 - gi|73959219|ref|XP_852321.1| PREDICTED: similar to Axin-1 (Axis inhibition protein 1) (Fused protein...
0.0 [1..859] [1..864]
gi|114660144 - gi|114660144|ref|XP_001152990.1| PREDICTED: axin 1 isoform 2 [Pan troglodytes]
0.0 [1..821] [1..821]

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Predicted Domain #1
Region A:
Residues: [1-220]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIQEQGFPL DLGASFTEDA PRPPVPGEEG ELVSTDPRPA SYSFCSGKGV GIKGETSTAT  60
   61 PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIS LFRTFLKQEG CADLLDFWFA 120
  121 CTGFRKLEPC DSNEEKRLKL ARAIYRKYIL DNNGIVSRQT KPATKSFIKG CIMKQLIDPA 180
  181 MFDQAQTEIQ ATMEENTYPS FLKSDIYLEY TRTGSESPKV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.09691
Match: 1dk8A
Description: Axin RGS-homologous domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [221-342]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSDQSSGSGT GKGISGYLPT LNEDEEWKCD QDMDEDDGRD AAPPGRLPQK LLLETAAPRV  60
   61 SSSRRYSEGR EFRYGSWREP VNPYYVNAGY ALAPATSAND SEQQSLSSDA DTLSLTDSSV 120
  121 DG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [343-561]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPPYRIRKQH RREMQESVQV NGRVPLPHIP RTYRVPKEVR VEPQKFAEEL IHRLEAVQRT  60
   61 REAEEKLEER LKRVRMEEEG EDGDPSSGPP GPCHKLPPAP AWHHFPPRCV DMGCAGLRDA 120
  121 HEENPESILD EHVQRVLRTP GRQSPGPGHR SPDSGHVAKM PVALGGAASG HGKHVPKSGA 180
  181 KLDAAGLHHH RHVHHHVHHS TARPKEQVEA EATRRAQSS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [562-762]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FAWGLEPHSH GARSRGYSES VGAAPNASDG LAHSGKVGVA CKRNAKKAES GKSASTEVPG  60
   61 ASEDAEKNQK IMQWIIEGEK EISRHRRTGH GSSGTRKPQP HENSRPLSLE HPWAGPQLRT 120
  121 SVQPSHLFIQ DPTMPPHPAP NPLTQLEEAR RRLEEEEKRA SRAPSKQRYV QEVMRRGRAC 180
  181 VRPACAPVLH VVPAVSDMEL S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [763-862]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETETRSQRKV GGGSAQPCDS IVVAYYFCGE PIPYRTLVRG RAVTLGQFKE LLTKKGSYRY  60
   61 YFKKVSDEFD CGVVFEEVRE DEAVLPVFEE KIIGKVEKVD 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.221849
Match: 1wspA
Description: Crystal structure of axin dix domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle