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View Structure Prediction Details

Protein: AXIN1
Organism: Homo sapiens
Length: 862 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AXIN1.

Description E-value Query
Range
Subject
Range
gi|66350811, gi|... - gi|66350948|emb|CAI95600.1| axin 1 [Homo sapiens], gi|66350811|emb|CAI95589.1| axin 1 [Homo sapiens]
0.0 [1..862] [50..911]
gi|149269133, gi... - gi|82993040|ref|XP_920000.1| PREDICTED: similar to Axin-1 (Axis inhibition protein 1) (Fused protein...
0.0 [1..862] [131..993]
gi|73959219 - gi|73959219|ref|XP_852321.1| PREDICTED: similar to Axin-1 (Axis inhibition protein 1) (Fused protein...
0.0 [1..859] [1..864]
gi|114660144 - gi|114660144|ref|XP_001152990.1| PREDICTED: axin 1 isoform 2 [Pan troglodytes]
0.0 [1..821] [1..821]

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Predicted Domain #1
Region A:
Residues: [1-220]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIQEQGFPL DLGASFTEDA PRPPVPGEEG ELVSTDPRPA SYSFCSGKGV GIKGETSTAT  60
   61 PRRSDLDLGY EPEGSASPTP PYLKWAESLH SLLDDQDGIS LFRTFLKQEG CADLLDFWFA 120
  121 CTGFRKLEPC DSNEEKRLKL ARAIYRKYIL DNNGIVSRQT KPATKSFIKG CIMKQLIDPA 180
  181 MFDQAQTEIQ ATMEENTYPS FLKSDIYLEY TRTGSESPKV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.09691
Match: 1dk8A
Description: Axin RGS-homologous domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [221-342]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSDQSSGSGT GKGISGYLPT LNEDEEWKCD QDMDEDDGRD AAPPGRLPQK LLLETAAPRV  60
   61 SSSRRYSEGR EFRYGSWREP VNPYYVNAGY ALAPATSAND SEQQSLSSDA DTLSLTDSSV 120
  121 DG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [343-561]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPPYRIRKQH RREMQESVQV NGRVPLPHIP RTYRVPKEVR VEPQKFAEEL IHRLEAVQRT  60
   61 REAEEKLEER LKRVRMEEEG EDGDPSSGPP GPCHKLPPAP AWHHFPPRCV DMGCAGLRDA 120
  121 HEENPESILD EHVQRVLRTP GRQSPGPGHR SPDSGHVAKM PVALGGAASG HGKHVPKSGA 180
  181 KLDAAGLHHH RHVHHHVHHS TARPKEQVEA EATRRAQSS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [562-762]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FAWGLEPHSH GARSRGYSES VGAAPNASDG LAHSGKVGVA CKRNAKKAES GKSASTEVPG  60
   61 ASEDAEKNQK IMQWIIEGEK EISRHRRTGH GSSGTRKPQP HENSRPLSLE HPWAGPQLRT 120
  121 SVQPSHLFIQ DPTMPPHPAP NPLTQLEEAR RRLEEEEKRA SRAPSKQRYV QEVMRRGRAC 180
  181 VRPACAPVLH VVPAVSDMEL S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [763-862]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETETRSQRKV GGGSAQPCDS IVVAYYFCGE PIPYRTLVRG RAVTLGQFKE LLTKKGSYRY  60
   61 YFKKVSDEFD CGVVFEEVRE DEAVLPVFEE KIIGKVEKVD 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.221849
Match: 1wspA
Description: Crystal structure of axin dix domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle