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View Structure Prediction Details

Protein: STE11
Organism: Saccharomyces cerevisiae
Length: 738 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STE11.

Description E-value Query
Range
Subject
Range
STE11 - Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathwa...
0.0 [1..738] [1..738]
gi|189491751, gi... - gi|57284082|emb|CAI43167.1| p21 protein (Cdc42/Rac)-activated kinase 3 [Homo sapiens], gi|57284006|e...
gi|157170250 - gi|157170250|gb|AAI52762.1| P21 protein (Cdc42/Rac)-activated kinase 3 [synthetic construct]
ENSPTRT00000049237 - null
0.0 [106..734] [10..520]
PAK3_RAT - Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1
0.0 [106..734] [10..520]
gi|3420949 - gi|3420949|gb|AAC31969.1| Cdc42/Rac effector kinase; PAK-3 [Mus musculus]
0.0 [106..734] [10..520]
gi|1168176 - gi|1168176|gb|AAB35358.1| mPAK-3=p21Cdc42/Rac activated kinase [mice, fibroblast, Peptide, 543 aa]
0.0 [106..734] [10..520]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [108..734] [18..521]

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Predicted Domain #1
Region A:
Residues: [1-136]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKERPLNKA SMIRSPVDEI YMEQTQTAEG TDLLIGDEKT NDLPFVQLFL EEIGCTQYLD  60
   61 SFIQCNLVTE EEIKYLDKDI LIALGVNKIG DRLKILRKSK SFQRDKRIEQ VNRLKNLMEK 120
  121 VSSLSTATLS MNSELI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.89
Match: 1b0xA
Description: EphA4 receptor tyrosine kinases
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [137-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEKHCVIFIL NDGSAKKVNV NGCFNADSIK KRLIRRLPHE LLATNSNGEV TKMVQDYDVF  60
   61 VLDYTKNVLH LLYDVELVTI CHANDRVEKN RLIFVS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [233-369]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDQTPSDKAI STSKKLYLRT LSALSQVGPS SSNLLAQNKG ISHNNAEGKL RIDNTEKDRI  60
   61 RQIFNQRPPS EFISTNLAGY FPHTDMKRLQ KTMRESFRHS ARLSIAQRRP LSAESNNIGD 120
  121 ILLKHSNAVD MALLQGL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.423 a.4.5 "Winged helix" DNA-binding domain
View Download 0.513 a.1.1 Globin-like
View Download 0.417 a.4.5 "Winged helix" DNA-binding domain
View Download 0.407 d.54.1 Enolase N-terminal domain-like
View Download 0.391 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.385 d.15.4 2Fe-2S ferredoxin-like
View Download 0.379 a.116.1 GTPase activation domain, GAP
View Download 0.378 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.378 a.1.1 Globin-like
View Download 0.371 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.362 a.4.5 "Winged helix" DNA-binding domain
View Download 0.360 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.351 a.1.1 Globin-like
View Download 0.349 a.75.1 Ribosomal protein S7
View Download 0.341 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.331 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.325 d.54.1 Enolase N-terminal domain-like
View Download 0.322 a.60.7 5' to 3' exonuclease, C-terminal subdomain
View Download 0.319 f.18.1 F1F0 ATP synthase subunit A
View Download 0.316 a.91.1 Regulator of G-protein signalling, RGS
View Download 0.311 a.25.1 Ferritin-like
View Download 0.310 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.305 a.4.5 "Winged helix" DNA-binding domain
View Download 0.277 a.158.1 F-box domain
View Download 0.249 a.39.3 Cloroperoxidase
View Download 0.247 a.141.1 Frizzled cystein-rich domain
View Download 0.246 a.74.1 Cyclin-like
View Download 0.241 a.24.5 TMV-like viral coat proteins
View Download 0.237 a.54.1 Domain of early E2A DNA-binding protein, ADDBP
View Download 0.234 a.1.1 Globin-like
View Download 0.233 a.170.1 BRCA2 helical domain
View Download 0.220 b.40.4 Nucleic acid-binding proteins
View Download 0.219 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.212 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.212 a.85.1 Hemocyanin, N-terminal domain
View Download 0.210 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.203 a.45.1 Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #4
Region A:
Residues: [370-556]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQTRLSSKLD TTKIPKLAHK RPEDNDAISN QLELLSVESG EEEDHDFFGE DSDIVSLPTK  60
   61 IATPKNWLKG ACIGSGSFGS VYLGMNAHTG ELMAVKQVEI KNNNIGVPTD NNKQANSDEN 120
  121 NEQEEQQEKI EDVGAVSHPK TNQNIHRKMV DALQHEMNLL KELHHENIVT YYGASQEGGN 180
  181 LNIFLEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 480.457575
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [557-738]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPGGSVSSML NNYGPFEESL ITNFTRQILI GVAYLHKKNI IHRDIKGANI LIDIKGCVKI  60
   61 TDFGISKKLS PLNKKQNKRA SLQGSVFWMS PEVVKQTATT AKADIWSTGC VVIEMFTGKH 120
  121 PFPDFSQMQA IFKIGTNTTP EIPSWATSEG KNFLRKAFEL DYQYRPSALE LLQHPWLDAH 180
  181 II

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 480.457575
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle