YRC Public Data Repository - Protein Structure Prediction

Protein:	BLM10
Organism:	Saccharomyces cerevisiae
Length:	2143 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BLM10.

Description	E-value	Query Range	Subject Range
gi\|32409989, gi\|... - gi\|32409989\|ref\|XP_325475.1\| hypothetical protein [Neurospora crassa], gi\|28921586\|gb\|EAA30880.1\| hy... gi\|85095608 - gi\|85095608\|ref\|XP_960116.1\| hypothetical protein [Neurospora crassa OR74A]	0.0	[197..2134]	[48..1946]
gi\|46437612, gi\|... - gi\|68480080\|ref\|XP_715965.1\| hypothetical protein CaO19.9728 [Candida albicans SC5314], gi\|68479947\|... orf19.2182, orf1... - BLM3 CGDID:CAL0005443 Assembly 19, Contig19-10141 (45390, 38788) CDS, reverse complemented, translat...	0.0	[8..2142]	[17..2199]
BLM10_YEAST - Proteasome activator BLM10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BLM10 PE=1 SV... BLM10 - Proteasome activator subunit; found in association with core particles, with and without the 19S reg...	0.0	[1..2143]	[1..2143]
gi\|44985857, gi\|... - gi\|45201074\|ref\|NP_986644.1\| AGL022Wp [Ashbya gossypii ATCC 10895], gi\|44985857\|gb\|AAS54468.1\| AGL02... gi\|44985857 - gi\|44985857\|gb\|AAS54468.1\| AGL022Wp [Ashbya gossypii ATCC 10895]	0.0	[5..2143]	[2..2145]
gi\|49096568, gi\|... - gi\|67538874\|ref\|XP_663211.1\| hypothetical protein AN5607.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	0.0	[209..2143]	[59..1968]
IPI:IPI00192488.... - Ensembl_locations(Chr-bp):14_random-3982016;14-102730670 TEMO, (NM_023986) TEMO [Rattus norvegicus] gi\|9954445, gi\|4... - gi\|9954445\|gb\|AAG09060.1\|AF296169_1 TEMO [Mus musculus], gi\|40556272\|ref\|NP_598774.1\| proteasome (pr...	0.0	[1103..2143]	[764..1803]
gi\|85566853, gi\|... - gi\|85566853\|gb\|AAI12170.1\| Proteasome (prosome, macropain) activator subunit 4 [Homo sapiens], gi\|40...	0.0	[1103..2143]	[690..1729]
gi\|157762280 - gi\|157762280\|ref\|XP_001673482.1\| Hypothetical protein CBG08524 [Caenorhabditis briggsae AF16] gi\|39583853, gi\|... - gi\|39583853\|emb\|CAE63943.1\| Hypothetical protein CBG08524 [Caenorhabditis briggsae], gi\|187032580\|em...	0.0	[1105..2142]	[851..1902]

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Predicted Domain #1

Region A:
Residues: [1-230]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTANNDDDIK SPIPITNKTL SQLKRFERSP GRPSSSQGEI KRKKSRLYAA DGRPHSPLRA  60
   61 RSATPTLQDQ KLFNGMDSTS LLNERLQHYT LDYVSDRAQH MKNIYDPSSR WFSRSVRPEF 120
  121 PIEEFLPYKT ESHEDQAKYL CHVLVNLYIA ISSLDIQGLI SISSKDLADL KKEVDDLALK 180
  181 TDLFRLSNNT AENDLLGNDI ADYDDAEGLE DELDEYFDLA GPDFNATGKI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [231-300]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAKSATIVNV NHWTNELKNC LHFDFPVALR KSLATVYYYL SLVQGQKVYR QMHVDMFERL  60
   61 VSLDDDRTNF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [301-377]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TELLQKQGLL LDHQIMLNFL CEFLPYPDPD YARYELSSKE DLQLFRLLLK HAHNAKPFFD  60
   61 KSKESLLVDT MNFLLSS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [378-449]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAPSTMMAVM PIVTSVVPYH YHIHSKIIDY FPFCYSIWSS VSANVAIDTH MYDFVGSISK  60
   61 DVHNKILSSE HE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [450-554]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDVVGVEFGE FGIFTDDQMT FMFNRLQGHL RTDGQIHSYS RTVKPFVYAI NGSKKDRFFE  60
   61 KLVSLAKAIE TFIHPSNNGF WTKPNAKFVH AFIKSYHGRV KYEED

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [555-707]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ICARGVTNGI CLTSFCHEEI VEIFLNIISL GSQNKNPDIA NYYISCFAYL LELDPSNAYL  60
   61 IYDKILIDLY DTLADQFINS RHRIISSLKQ FTRVIRFIVM DKLYRVHITN VLSMLVSKLD 120
  121 MNDTNLTSNL INGIVSIAAF IPIQDLTGED DYI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [708-856]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFESDTLPLV QQHFYHIKCG ESSKTFRVDD ELLNNAFKAS TTVFQSMLKV YVEKIFQLVD  60
   61 VDLEDSLVTK INQTTMILQE SMDDKIFNYF ASLLQRNFWS NDSFKEKDPN YELVTIPLAA 120
  121 LVRRNNGLSK ELVRTLLFHI KEQIKRGAG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8

Region A:
Residues: [857-1034]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVRSTSEIQQ RDVKLVLYLT ALNDVLRQCH ESLLEYSDEL ITFMKYLYDN VTNPPLDVIT  60
   61 SIVIHSALAT LCTTEITDCR LFPEDSKIPE KDRWGGLQFD PRRFDKQHLS FQWHVPSSDE 120
  121 ITLSISILES LSEYCINNVE ELMKAPRHDS EYGDMIQKYV LVMTHTLSGS SLLFDPDF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9

Region A:
Residues: [1035-1165]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKYRTQSNLS YREKLILLKN IRENNCDPQE LDIDIEQIRS GKDDEDYIES KDIEAGLNAG  60
   61 VSDVVQLRDE FPDELIVDEE VVSEMPSGVN TPIAGTHGTD NSAMSSDLAF RDLDIYTCNY 120
  121 YFGNTTEEKL Q

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10

Region A:
Residues: [1166-1328]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPQYLQVHRV RARIGHFFHK LYVFLSTNFE NNTNMFQILL HGLKVWFTDL GQETVFNEDP  60
   61 NAFIDVDFLE NVQSLSHVNE PFTRTNFAIR ANSLHQSRVL LHSTNRKASK LENLLLVDII 120
  121 QLATSLYPDI YKPAQGTLVH CMKQLVGSYG VVINKIIPSL EKA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	2.96084803796407	bayes_pls_golite062009
hydrolase activity	2.62777210765927	bayes_pls_golite062009
nucleic acid binding	2.2915564382469	bayes_pls_golite062009
transcription regulator activity	1.78626120336243	bayes_pls_golite062009
DNA binding	1.62962293446832	bayes_pls_golite062009
protein binding	1.61131270705552	bayes_pls_golite062009
transcription factor activity	0.931585995872658	bayes_pls_golite062009
structural molecule activity	0.907636867485115	bayes_pls_golite062009
translation regulator activity	0.845133720454593	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.825554268911902	bayes_pls_golite062009
translation initiation factor activity	0.594620724124658	bayes_pls_golite062009
mRNA binding	0.328122666854777	bayes_pls_golite062009
RNA binding	0.243875756041061	bayes_pls_golite062009
transcription activator activity	0.005251231402011	bayes_pls_golite062009

Predicted Domain #11

Region A:
Residues: [1329-1412]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKDHDYMKIQ VILNVLLIKK IHRKLMTDYK DIGRLIFLLI ECCRVNELEI GMYADKILTD  60
   61 IVIGIKIPSS VCVISDQAFL PLAP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12

Region A:
Residues: [1413-1588]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDGTINLQVE AVKLAKKKKR EYYLSLLVDL QDKLLDKLDN EKDMGWKIRM FILRFVTQIQ  60
   61 SNLESKPDKR AVFSIISQIS TKHPEIIHLV VKSLLSTCNK IISLSDYEYD ITRAYKNEFN 120
  121 PSFVEILDTS TTSFPKTFTE EMNNFDNPKY FIDLRAYVGW LCWGRLMYVM SPKALK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #13

Region A:
Residues: [1589-1813]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNLRENELEV LKTAGHLLTR EFLRDVTMNL VQDNETRGVF SSGNVSFFSL VILLISSGFC  60
   61 ELNMSDLFEL CESYYNKDDK ASMIMSVEIV AGLVCGSKFM SVSDLDKRDT FIENFLAKCL 120
  121 DYELNHDAFE IWSTLAWWLP AVVDLRRSKT FFCHFINADG MFDRESDAAT HQTSKIYMLR 180
  181 SILMSMEFRA PDVGKLFDEL VFDHPYDQVR QAVAKLLTTL VQNQS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #14

Region A:
Residues: [1814-1982]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPSISDPTTL LEAERNDPDG LGLPLKSVPE KVDAYIKKQF EIIKNLEDSV VGLNPQQFIK  60
   61 TDYFYRTSTI FYWIKEMARG PNKVLLVPYL VDYVLPFLIG LVKHKDVCAL ASLDPVRLYA 120
  121 GLGYMPIRKN HVAAIVDYVC SSNVALSSNQ TKLQLAFIQH FLSAELLQL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #15

Region A:
Residues: [1983-2143]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEEEKNKILE FVVSNLYNEQ FVEVRVRAAS ILSDIVHNWK EEQPLLSLIE RFAKGLDVNK  60
   61 YTSKERQKLS KTDIKIHGNV LGLGAIISAF PYVFPLPPWI PKQLSNLSSW ARTSGMTGQA 120
  121 AKNTISEFKK VRADTWKFDR ASFNTEELED LEGVLWRSYY A

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: