YRC Public Data Repository - Protein Structure Prediction

Protein:	NPR2
Organism:	Saccharomyces cerevisiae
Length:	615 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NPR2.

Description	E-value	Query Range	Subject Range
NPR2 - Component of an evolutionarily conserved Npr2/3 complex that mediates downregulation of TORC1 activi...	694.0	[0..1]	[615..10]
orf19.328, orf19... - NPR2 CGDID:CAL0004714 Assembly 19, Contig19-10046 (170140, 168158) CDS, reverse complemented, transl... gi\|46441873, gi\|... - gi\|68471960\|ref\|XP_720023.1\| hypothetical protein CaO19.328 [Candida albicans SC5314], gi\|68471697\|r...	597.0	[0..6]	[615..5]
gi\|44981451, gi\|... - gi\|45185696\|ref\|NP_983412.1\| ACR009Wp [Ashbya gossypii ATCC 10895], gi\|44981451\|gb\|AAS51236.1\| ACR00... gi\|44981451 - gi\|44981451\|gb\|AAS51236.1\| ACR009Wp [Ashbya gossypii ATCC 10895]	562.0	[0..1]	[498..8]
gi\|50306291, gi\|... - gi\|50306291\|ref\|XP_453118.1\| unnamed protein product [Kluyveromyces lactis], gi\|49642252\|emb\|CAH0021... gi\|49642252 - gi\|49642252\|emb\|CAH00214.1\| KLLA0D01067p [Kluyveromyces lactis]	446.0	[0..1]	[615..1]
gi\|85118237 - gi\|85118237\|ref\|XP_965415.1\| hypothetical protein [Neurospora crassa OR74A] gi\|32419545, gi\|... - gi\|38566965\|emb\|CAE76266.1\| related to nitrogen permease regulator [Neurospora crassa], gi\|32419545\|...	427.0	[0..11]	[607..2]
gi\|67516315, gi\|... - gi\|67516315\|ref\|XP_658043.1\| hypothetical protein AN0439.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	422.0	[0..11]	[491..2]
gi\|49655240, gi\|... - gi\|50422021\|ref\|XP_459572.1\| hypothetical protein DEHA0E06523g [Debaryomyces hansenii CBS767], gi\|49...	422.0	[0..6]	[615..4]
gi\|49528660, gi\|... - gi\|50293871\|ref\|XP_449347.1\| unnamed protein product [Candida glabrata], gi\|49528660\|emb\|CAG62321.1\|... gi\|49528660 - gi\|49528660\|emb\|CAG62321.1\| unnamed protein product [Candida glabrata]	418.0	[0..1]	[614..1]
gi\|38102131, gi\|... - gi\|39974379\|ref\|XP_368580.1\| hypothetical protein MGG_00664 [Magnaporthe grisea 70-15], gb\|EAA49006....	410.0	[0..11]	[526..2]

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Predicted Domain #1

Region A:
Residues: [1-78]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSYFQGFVP IHTIFYSVFH PTEGSKIKYE FPPNNLKNHG INFNTFKNYI IPKPILCHKL  60
   61 ITFKYGTYRI VCYPVTIN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.589	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.589	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.574	d.229.1	Putative cell cycle protein MesJ, middle and C-terminal domain
View	Download	0.530	d.95.2	Homing endonucleases
View	Download	0.530	d.95.2	Homing endonucleases
View	Download	0.500	d.58.7	RNA-binding domain, RBD
View	Download	0.493	d.15.1	Ubiquitin-like
View	Download	0.456	a.60.8	HRDC-like
View	Download	0.448	a.3.1	Cytochrome c
View	Download	0.444	d.15.7	Immunoglobulin-binding domains

Predicted Domain #2

Region A:
Residues: [79-174]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPIYARNFFS FNFVFVFPYD CETSPYEPAI TRLGKMFKVL EEQNQLLSKS ERDPVFFDLK  60
   61 VLENSTTTPS TAGPSSTPNP SSNTTPTHPT SEKDTK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.605	N/A	N/A	a.163.1	Crustacean CHH/MIH/GIH neurohormone
View	Download	0.605	N/A	N/A	a.163.1	Crustacean CHH/MIH/GIH neurohormone
View	Download	0.550	N/A	N/A	a.151.1	Glutamyl tRNA-reductase dimerization domain
View	Download	0.507	N/A	N/A	a.74.1	Cyclin-like
View	Download	0.507	N/A	N/A	a.74.1	Cyclin-like
View	Download	0.463	N/A	N/A	d.244.1	Description not found.
View	Download	0.458	N/A	N/A	a.25.1	Ferritin-like
View	Download	0.440	N/A	N/A	a.24.17	Group V grass pollen allergen
View	Download	0.440	N/A	N/A	a.24.17	Group V grass pollen allergen

Predicted Domain #3

Region A:
Residues: [175-342]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMRSSRYSDL IKDLGLPQSA FSIQDLLMRI FQDLNNYSEC LIPIDEGNAV DIKIFPLLRP  60
   61 PTTCVSLEDV PLSSVNLKKI IDVNWDPTMM SIVPYIDGLN SIAKISKLSN SDPGLVIECI 120
  121 RHLIYYKCVT LSDIFQFSNI YAPSSLIRNF LTDPLMASDC QSYVTFPE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [343-426]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSKISNLPLN KSLGSGDQDS PSFSVRRKSK SSSIPSNPDS RTTSFSSTSR VSQNSSLNSS  60
   61 FSSIYKDWRQ SQTSCSSSNI HVIN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.370	a.70.1	N-terminal domain of the delta subunit of the F1F0-ATP synthase
View	Download	0.362	a.165.1	Myosin phosphatase inhibitor 17kDa protein, CPI-17
View	Download	0.318	a.3.1	Cytochrome c
View	Download	0.318	a.3.1	Cytochrome c
View	Download	0.304	a.60.6	DNA polymerase beta, N-terminal domain-like
View	Download	0.301	a.60.6	DNA polymerase beta, N-terminal domain-like
View	Download	0.287	a.4.1	Homeodomain-like
View	Download	0.247	a.165.1	Myosin phosphatase inhibitor 17kDa protein, CPI-17
View	Download	0.234	a.3.1	Cytochrome c

Predicted Domain #5

Region A:
Residues: [427-521]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRNRFLPTRS CLFDLYRSLS QGQTLKTWYE SKYMILKENN IDIRRFITFG LEKRIIYRCY  60
   61 SFPVMINAGS REPKEMTPII TKDLVNNDKL LEKRN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.762	a.283.1	Description not found.
View	Download	0.743	a.186.1	Description not found.
View	Download	0.597	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.597	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.587	a.130.1	Chorismate mutase II
View	Download	0.587	a.130.1	Chorismate mutase II
View	Download	0.568	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.568	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.551	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.533	a.4.5	"Winged helix" DNA-binding domain

Predicted Domain #6

Region A:
Residues: [522-615]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HNHLLSATGS RNTAQSGNLK PERPSKVSFE MQRVSSLATG KSTMPKLSDE EEGILEESIR  60
   61 NAETFDKICV LLSKPKLEVE SYLNELGEFK VINS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.499	a.164.1	C-terminal domain of DFF45/ICAD (DFF-C domain)
View	Download	0.429	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.408	a.8.4	Description not found.
View	Download	0.394	a.4.14	Description not found.
View	Download	0.339	a.74.1	Cyclin-like
View	Download	0.339	a.74.1	Cyclin-like
View	Download	0.317	a.74.1	Cyclin-like
View	Download	0.256	a.36.1	Signal peptide-binding domain
View	Download	0.228	a.74.1	Cyclin-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits