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View Structure Prediction Details

Protein: TPO3
Organism: Saccharomyces cerevisiae
Length: 622 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPO3.

Description E-value Query
Range
Subject
Range
TPO3_YEAST - Polyamine transporter 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPO3 PE=1 SV=1
TPO3 - Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the m...
0.0 [1..622] [1..622]
gi|60467752, gi|... - gi|60467752|gb|EAL65769.1| hypothetical protein DDB0191430 [Dictyostelium discoideum], gi|29500764|g...
gi|60467752, gi|... - gi|66810832|ref|XP_639123.1| major facilitator superfamily transporter [Dictyostelium discoideum AX4...
0.0 [5..575] [416..1015]
gi|9801985, gi|7... - gi|9801985|gb|AAF99573.1|AF188621_1 fluconazole resistance protein [Candida albicans], gi|76573588|d...
gi|68469252, gi|... - gi|77022662|ref|XP_888775.1| hypothetical protein CaO19_6577 [Candida albicans SC5314], gi|68470277|...
0.0 [11..619] [4..610]
gi|21214009 - gi|21214009|emb|CAD32176.1| multidrug resistant protein [Acremonium chrysogenum]
0.0 [108..619] [3..526]
gi|85092504 - gi|85092504|ref|XP_959425.1| hypothetical protein NCU06077 [Neurospora crassa OR74A]
gi|32410903, gi|... - gi|32410903|ref|XP_325932.1| hypothetical protein [Neurospora crassa], gi|28920843|gb|EAA30189.1| co...
0.0 [30..610] [2..594]
YCT4_SCHPO - Uncharacterized transporter C794.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC7...
SPCC794.04c - membrane transporter
0.0 [94..618] [22..547]

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Predicted Domain #1
Region A:
Residues: [1-163]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRQESINSF NSDETSSLSD VESQQPQQYI PSESGSKSNM APNQLKLTRT ETVKSLQDMG  60
   61 VSSKAPVPDV NAPQSSKNKI FPEEYTLETP TGLVPVATLH SIGRTSTAIS RTRTRQIDGA 120
  121 SSPSSNEDAL ESDNNEKGKE GDSSGANDEA PDLDPEIEFV TFV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [164-622]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGDPENPHNW PAWIRWSYTV LLSILVICVA YGSACISGGL GTVEKKYHVG MEAAILSVSL  60
   61 MVIGFSLGPL IWSPVSDLYG RRVAYFVSMG LYVIFNIPCA LAPNLGSLLA CRFLCGVWSS 120
  121 SGLCLVGGSI ADMFPSETRG KAIAFFAFAP YVGPVVGPLV NGFISVSTGR MDLIFWVNMA 180
  181 FAGVMWIISS AIPETYAPVI LKRKAARLRK ETGNPKIMTE QEAQGVSMGE MMRACLLRPL 240
  241 YFSVTEPVLV ATCFYVCLIY SLLYAFFFAF PVIFGELYGY KDNLVGLMFI PIVIGALWAL 300
  301 ATTFYCENKY LQIVKQRKPT PEDRLLGAKI GAPFAAIALW ILGATAYKHI IWVGPASAGL 360
  361 AFGFGMVLIY YSLNNYIIDC YVQYASSALA TKVFLRSAGG AAFPLFTIQM YHKLNLHWGS 420
  421 WLLAFISTAM IALPFAFSYW GKGLRHKLSK KDYSIDSIE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 5.366532
Match: PF00083
Description: Sugar (and other) transporter

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transporter activity 4.09176719149278 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.54194478414824 bayes_pls_golite062009
ion transmembrane transporter activity 2.21266150105753 bayes_pls_golite062009
cation transmembrane transporter activity 1.79369588808394 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
binding 1.3181781780038 bayes_pls_golite062009
organic acid transmembrane transporter activity 1.24937104052238 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
polyol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.812001619402678 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009
cation:sugar symporter activity 0.143419068761182 bayes_pls_golite062009
sugar:hydrogen symporter activity 0.143419068761182 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle