YRC Public Data Repository - Protein Structure Prediction

Protein:	YPR117W
Organism:	Saccharomyces cerevisiae
Length:	2489 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPR117W.

Description	E-value	Query Range	Subject Range
YF49_SCHPO - UPF0648 protein C3H5.09c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC3H5.09c PE=2 ... SPAC3H5.09c - conserved fungal protein	0.0	[792..2427]	[807..2561]
gi\|85081746 - gi\|85081746\|ref\|XP_956778.1\| hypothetical protein NCU00459 [Neurospora crassa OR74A] gi\|28917855, gi\|... - gi\|32403864\|ref\|XP_322545.1\| hypothetical protein [Neurospora crassa], gi\|28917855\|gb\|EAA27542.1\| co...	0.0	[808..2466]	[940..2817]
YP117_YEAST - Uncharacterized protein YPR117W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPR117W ... gi\|151942894 - gi\|151942894\|gb\|EDN61240.1\| conserved protein [Saccharomyces cerevisiae YJM789] YPR117W - Putative protein of unknown function gi\|190408044 - gi\|190408044\|gb\|EDV11309.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]	0.0	[1..2489]	[1..2489]
gi\|24656617, gi\|... - gi\|7292333\|gb\|AAF47740.1\| CG14967 [Drosophila melanogaster], gi\|24656617\|ref\|NP_647789.1\| CG14967 [D...	0.0	[744..1448]	[762..1373]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[825..1439]	[145..681]
gi\|28972069 - gi\|28972069\|dbj\|BAC65488.1\| mKIAA0100 protein [Mus musculus]	0.0	[825..1439]	[59..595]
gi\|30696235 - gi\|30696235\|ref\|NP_176121.2\| SAB (SABRE) [Arabidopsis thaliana]	0.0	[734..1431]	[802..1505]

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Predicted Domain #1

Region A:
Residues: [1-739]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMLPWSQIR DVSKLLLGFM LFIISIQKIA SILMSWILML RHSTIRKISF GYFFGTSIRR  60
   61 AFILTDFAQI YIGKITLRIG WKPGIVFHNV DLKLFGKDSH ITAHSTKDSR TYFNPRDQTF 120
  121 TFVINRRVLS ILKLVFSFST FFHTLALTVP NGKQYKLNIG SITISHPHDD TIKLEAFLHD 180
  181 FTHPETKDTL NHTGFFMVCK IGKEDDTGSN CTKVILKNWK SSLKISDVCW HLPEKKGKNL 240
  241 HSEPVEPFSA GDDAEMLTSY RKMLKPFHYP LKTLNILDLK VENVKLIYKK KFTIRISSAQ 300
  301 LYLESISILN NVSALELLPL NKPTWGDFEL SLSANAVVVD IDGNTAVRIP FGNVILTSDI 360
  361 LLFLLDNVPL RRTKVSSILN IINPSVFLTI HQVLEVLHLV DKFDSPETSS CTNTNDRSLN 420
  421 ILDLDIDRLP SFNFELLMSN FISRLHISDE ENVTFKVFST HALFSRNNLS MTPKKGQVMQ 480
  481 IRPDWPFAKT ALVSDQLSNY IKIVGTSLSY LRIPTEQDAN PVSIPVCGFE RLDTFLDEFS 540
  541 NSKLIVQSTL RHSYVSLENI EVLHTLSRAF DKIYLLISSR TKRNAAHKAN GGKLGDLNEA 600
  601 KKTFNWSLKL RMKDISCSLL VAGFLPKNLD PVEAENFNLS DVTRGAKVVF TESILLADSQ 660
  661 EKNFTIIDAS VYRFMDGTTY KPSPEVIIQF TNLLLSFNDS DEIHFSLPKI KFKMDVNIIW 720
  721 LWFYIRSIWI KFRPNSKLS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [740-1475]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNSVSSVKSV NVLDRLRVDI GKMIIELTLP HNTEVLLIFE RIGLSSSTKN LTIASLSAYV  60
   61 VSVYVKHIKV YVSLLNINDF ELDTEELICK KSAVINTSLI HFHAEYHFRF YMITDNIVTL 120
  121 YKSFKQIKLA FSNLNEFKRL YPQQQFPKKV PNLHICCQDF LIDIEEDPFE QELGLILKVG 180
  181 VLEQRERLKK LEEFKEKLST YEDMNVRLRS LYDTSRGQSF FPEFYANDQE YEQKAYLRLL 240
  241 ENFSTSWIAR YRKAKLSFYG MPYRVISREE LGTKYHLFTR QKTSTVANLV VKDLDFKLGS 300
  301 PSFPLDNYMD FVYQYGKKVP KSTEYTLLII LGLKIKSALW ELRLRDYPIP AISFPDTFTT 360
  361 GDVVFAEKMP APCALHTVYV PFVSSAQRSP YNDANTIYGL HIIRTINSVK TYFNIRSMVT 420
  421 SSSSARITWG KSLQPGYESL MLWFDFLTKP LIDPSKKLGF WDKFRYLVHG KWIYEFSEES 480
  481 EIHLNIKGSH DPYKITDDGA GLAFCWSGGT TIYVHNSTDP KEFLKIESQR FQLAVPDFAK 540
  541 VSKFDKVFMK LDGRVIWTLG LLFEQGDISK AGDEERFLPN RPHYEIQLMN PDGVADLDHH 600
  601 DTYKGFRTSF IHMSFGVYSS EHGSINSLYL APYALTHFFK WWNLFHTYTS GPIRQGRLFT 660
  661 DVLQNKTKFG RSLFTIAYQL HLKRLMVTHI YRHITTQYDL EKDRKITFTG LKGRFDSLKI 720
  721 DLHQKRVKLT HTNQKL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [1476-1700]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKSKPVWKFK MSRGEIDCAE ADIRILSTLF DQEAVKEILT SGLDGILEDE PSRPITPQDV  60
   61 EYLRESDWYD YEDYIDLNQV PLGSSLPLKL EAIPLLYSPR ISYFRKINDD GYVLAYPFGT 120
  121 EESHNCLIGK NHPELTQEKL ATERKREIEE QLKLLHITLS ELQSNKGGGS VSGNSERYAR 180
  181 ELKAEVAELN HRLHTVNTIL SDLKISETIP GGNTDGDSSS SLSDT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [1701-1935]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVNLENAPPI QNRISLLRTN TVESFVSMRK ASTMQVESTY DNRFMVHNIE LKIDNKIRHH  60
   61 LLEYASSAFE RKSMRFAVTY KSVTILKELL GNVLTGVRTS VEDYGSILED DLASNSEFIE 120
  121 HFEKLIREVP SDDFDYVDNY LFRLISPQVQ IKSDVERNAA VILAARDIEM GIIDIVQVYG 180
  181 KSGKRIPVDV DTIVETRYSA VSKDIQLFTL FKKDLEGPEG RFFHKNGYGS DKESD

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [1936-2437]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IWPPWIPLEM CFDGSLLDKH VFLKRRSMFL TYVAPNPLFF SANDTSAFSY DSRFRIAFPG  60
   61 LVLTSDCQQY CAVYAIAEDL LSFGSSLDEK VEKLSRILFT DEVRNNLENL DVSVVTALQE 120
  121 RIKELYYTRA YLKLHEPRLF MKSGQELTFD IQTSTLKLTL LMTAIKKTYD RMGSGNRVIQ 180
  181 KRLRWQVGTD ELIWELYDES KTPFVTIGLG PSTFIRSETS DGTNSNKVSI SSLQCFNQQE 240
  241 NPVYTELLAP FYENSSYNKN APMVEIFWIL GPSVGGISDL QDLIVSLQPL IFKMDHKTSE 300
  301 KLMNYLFPKI EQTSIEPNSP ELVPRSSTSS FFSSSPVLRH SLSNGSLSVY DAKDVDSWDL 360
  361 RSIQSKEGIK KHKGDHRKLS ASLFVQPDYN INEMVKRSGT FFNVKSIIIR KTLMSVCYKG 420
  421 SHSLLTDVNN LIVRVPVLKY HNKLWSREEF FTALKRDVVR IVLQHLGNII GNKFLPHKKE 480
  481 NKKKTSMEIH RLLSPDSQNR DN

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [2438-2489]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHILEVEGHN SFYSSTHSSD IRSINSDETY NENDGNGVKP FYPVTSEFSK NK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [986-1062]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WIARYRKAKL SFYGMPYRVI SREELGTKYH LFTRQKTSTV ANLVVKDLDF KLGSPSFPLD  60
   61 NYMDFVYQYG KKVPKST

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8

Region A:
Residues: [1063-1831]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EYTLLIILGL KIKSALWELR LRDYPIPAIS FPDTFTTGDV VFAEKMPAPC ALHTVYVPFV  60
   61 SSAQRSPYND ANTIYGLHII RTINSVKTYF NIRSMVTSSS SARITWGKSL QPGYESLMLW 120
  121 FDFLTKPLID PSKKLGFWDK FRYLVHGKWI YEFSEESEIH LNIKGSHDPY KITDDGAGLA 180
  181 FCWSGGTTIY VHNSTDPKEF LKIESQRFQL AVPDFAKVSK FDKVFMKLDG RVIWTLGLLF 240
  241 EQGDISKAGD EERFLPNRPH YEIQLMNPDG VADLDHHDTY KGFRTSFIHM SFGVYSSEHG 300
  301 SINSLYLAPY ALTHFFKWWN LFHTYTSGPI RQGRLFTDVL QNKTKFGRSL FTIAYQLHLK 360
  361 RLMVTHIYRH ITTQYDLEKD RKITFTGLKG RFDSLKIDLH QKRVKLTHTN QKLNKSKPVW 420
  421 KFKMSRGEID CAEADIRILS TLFDQEAVKE ILTSGLDGIL EDEPSRPITP QDVEYLRESD 480
  481 WYDYEDYIDL NQVPLGSSLP LKLEAIPLLY SPRISYFRKI NDDGYVLAYP FGTEESHNCL 540
  541 IGKNHPELTQ EKLATERKRE IEEQLKLLHI TLSELQSNKG GGSVSGNSER YARELKAEVA 600
  601 ELNHRLHTVN TILSDLKISE TIPGGNTDGD SSSSLSDTDV NLENAPPIQN RISLLRTNTV 660
  661 ESFVSMRKAS TMQVESTYDN RFMVHNIELK IDNKIRHHLL EYASSAFERK SMRFAVTYKS 720
  721 VTILKELLGN VLTGVRTSVE DYGSILEDDL ASNSEFIEHF EKLIREVPS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.02
Match:	1dg3A
Description:	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.301700930786307	bayes_pls_golite062009
catalytic activity	0.176212702885001	bayes_pls_golite062009

Predicted Domain #9

Region A:
Residues: [1832-2109]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDFDYVDNYL FRLISPQVQI KSDVERNAAV ILAARDIEMG IIDIVQVYGK SGKRIPVDVD  60
   61 TIVETRYSAV SKDIQLFTLF KKDLEGPEGR FFHKNGYGSD KESDIWPPWI PLEMCFDGSL 120
  121 LDKHVFLKRR SMFLTYVAPN PLFFSANDTS AFSYDSRFRI AFPGLVLTSD CQQYCAVYAI 180
  181 AEDLLSFGSS LDEKVEKLSR ILFTDEVRNN LENLDVSVVT ALQERIKELY YTRAYLKLHE 240
  241 PRLFMKSGQE LTFDIQTSTL KLTLLMTAIK KTYDRMGS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.32
Match:	2oevA
Description:	No description for 2oevA was found.

Predicted Domain #10

Region A:
Residues: [2110-2252]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNRVIQKRLR WQVGTDELIW ELYDESKTPF VTIGLGPSTF IRSETSDGTN SNKVSISSLQ  60
   61 CFNQQENPVY TELLAPFYEN SSYNKNAPMV EIFWILGPSV GGISDLQDLI VSLQPLIFKM 120
  121 DHKTSEKLMN YLFPKIEQTS IEP

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.32
Match:	1yvlA
Description:	Structure of Unphosphorylated STAT1
Matching Structure (courtesy of the PDB):

Predicted Domain #11

Region A:
Residues: [2253-2318]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSPELVPRSS TSSFFSSSPV LRHSLSNGSL SVYDAKDVDS WDLRSIQSKE GIKKHKGDHR  60
   61 KLSASL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12

Region A:
Residues: [2319-2489]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVQPDYNINE MVKRSGTFFN VKSIIIRKTL MSVCYKGSHS LLTDVNNLIV RVPVLKYHNK  60
   61 LWSREEFFTA LKRDVVRIVL QHLGNIIGNK FLPHKKENKK KTSMEIHRLL SPDSQNRDNS 120
  121 HILEVEGHNS FYSSTHSSDI RSINSDETYN ENDGNGVKPF YPVTSEFSKN K

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: