YRC Public Data Repository - Protein Structure Prediction

Protein:	FHL1
Organism:	Saccharomyces cerevisiae
Length:	936 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FHL1.

Description	E-value	Query Range	Subject Range
fkh2 - fork head transcription factor Fkh2 FKH2_SCHPO - Fork head protein homolog 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fkh2 PE=1 SV=1	283.0	[0..257]	[866..44]
FOXK2 - forkhead box K2	270.0	[0..282]	[812..36]
gi\|45190279, gi\|... - gi\|45190279\|ref\|NP_984533.1\| AEL327Wp [Ashbya gossypii ATCC 10895], gi\|44983175\|gb\|AAS52357.1\| AEL32... gi\|44983175 - gi\|44983175\|gb\|AAS52357.1\| AEL327Wp [Ashbya gossypii ATCC 10895]	261.0	[0..90]	[797..295]
gi\|73958174 - gi\|73958174\|ref\|XP_547003.2\| PREDICTED: similar to Forkhead box protein K1 (Myocyte nuclear factor) ...	256.0	[0..281]	[785..52]
gi\|109489518 - gi\|109489518\|ref\|XP_221212.4\| PREDICTED: similar to forkhead box K2 isoform 1 [Rattus norvegicus]	255.0	[0..282]	[801..177]
gi\|157170406 - gi\|157170406\|gb\|AAI52768.1\| Forkhead box K2 [synthetic construct] gi\|82937138, gi\|... - gi\|82937138\|ref\|XP_917797.1\| PREDICTED: similar to forkhead box K2 isoform 1 [Mus musculus], gi\|8293...	254.0	[0..282]	[801..188]
gi\|49644588, gi\|... - gi\|50310859\|ref\|XP_455452.1\| unnamed protein product [Kluyveromyces lactis], gi\|49644588\|emb\|CAG9816... gi\|49644588 - gi\|49644588\|emb\|CAG98160.1\| KLLA0F08206p [Kluyveromyces lactis]	254.0	[0..89]	[792..37]
gi\|28204898 - gi\|28204898\|gb\|AAH46369.1\| Foxk2 protein [Xenopus laevis]	254.0	[0..284]	[815..14]

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Predicted Domain #1

Region A:
Residues: [1-235]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGEMAIIES SNHVGTSSPT TETQFTIDSS ALKDQETKES ITNSPTSEVP IETKLPKSSD  60
   61 IVTEEKHPQN TTTDIENEVE NPVTDDNGNL KLELPDNLDN ADFSKLLEFD AKNDEALFNS 120
  121 NELLSHTMDP VNNIDLTHDH SREVSSKEDI NIEPVNPDED EREKTQDNTA AVKTEGIRNS 180
  181 EDTSIQKDEP TADAIYTDVH KLSVNKDTET LPTLVDEKNN MLHMRNNSIT PIMFQ

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [236-422]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHELVGQPPQ NTVTENNSTD AETTQRKLSE PIDASLPLPN EQPTIFAYAR LDFQSFTFYV  60
   61 QTLHAIIGRR SENDFSHKVD VNLGPSKSIS RRHAQIFYNF GTGRFELSII GKNGAFVDDI 120
  121 FVEKGNTVPL RNKTKIQIGQ IPFQFILPEQ ERNDDSKSPE NADIAESEIN TRNLKKNEPK 180
  181 SKKKITT

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	14.14
Match:
Description:	No description for 1gxcA was found.

Predicted Domain #3

Region A:
Residues: [423-581]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAKPKKAQTK PAVKKEKKPP KIPKKVYTLE EIPVEYRTKP TVSYSAMLTT CIRKYSTAKG  60
   61 MSLSEIYAGI RELFPYYKYC PDGWQSSVRH NLSLNKSFRK VSKEGKGWLW GLDEEYIAER 120
  121 ERQKKKQSEI AVAKAQAAQL KLEQQQHKLQ QVPQRGKKD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	151.69897
Match:	1d5vA
Description:	Adipocyte-transcription factor FREAC-11 (s12, fkh-14)
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [582-637]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVSQRSNVNA RKQNISQTLA ANRAASNRKN TASDNQRTMK YLQEQLVILT RDRKGL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.609	a.2.2	Ribosomal protein L29 (L29p)
View	Download	0.601	a.30.1	ROP protein
View	Download	0.592	f.17.5	Description not found.
View	Download	0.589	a.16.1	S15/NS1 RNA-binding domain
View	Download	0.567	f.17.5	Description not found.
View	Download	0.567	f.17.5	Description not found.
View	Download	0.563	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.548	a.2.9	C-terminal UvrC-binding domain of UvrB
View	Download	0.541	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain

Predicted Domain #5

Region A:
Residues: [638-713]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKQVIAAILT QALAMTINQV TQAAKNKGIT GNPLTALMDK NPQHLNLILA AAVNAATAKV  60
   61 TKGEVKQLVN PETTAA

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	11.07
Match:
Description:	No description for 1l8mA was found.

Predicted Domain #6

Region A:
Residues: [714-791]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AALAAKAQHS KPIRQPIVQT PHVPDRPPSQ LSASASSHPN NYLHDKQPGS FDPSSLSRFF  60
   61 QPRQNARATS SVAATSVP

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	11.07
Match:
Description:	No description for 1l8mA was found.

Predicted Domain #7

Region A:
Residues: [792-861]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAASQNVDAQ PKPKPAQDND LESESGTSSS SSSSSESGSE SDSGSDDGSA SGSGDNSSTS  60
   61 SESESESDSG

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	11.07
Match:
Description:	No description for 1l8mA was found.

Predicted Domain #8

Region A:
Residues: [862-936]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEVDEKNNKN EKIDSESIKN NESKDDIPSK DENSSNDNRE ISKTDEEGHD SKRRKVSEDI  60
   61 NEGITEVNVS LEEKL

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	11.07
Match:
Description:	No description for 1l8mA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits