YRC Public Data Repository - Protein Structure Prediction

Protein:	ERV2
Organism:	Saccharomyces cerevisiae
Length:	196 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERV2.

Description	E-value	Query Range	Subject Range
gi\|151942827 - gi\|151942827\|gb\|EDN61173.1\| sulfhydryl oxidase [Saccharomyces cerevisiae YJM789] gi\|207340379 - gi\|207340379\|gb\|EDZ68748.1\| YPR037Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190407982 - gi\|190407982\|gb\|EDV11247.1\| FAD-linked sulfhydryl oxidase ERV2, mitochondrial precursor [Saccharomyc... ERV2 - Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide... ERV2_YEAST - FAD-linked sulfhydryl oxidase ERV2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERV2 ...	9.0E-71	[1..196]	[1..196]
gi\|85089859 - gi\|85089859\|ref\|XP_958143.1\| hypothetical protein NCU09291 [Neurospora crassa OR74A] gi\|28919472, gi\|... - gi\|32423091\|ref\|XP_331983.1\| hypothetical protein [Neurospora crassa], gi\|28919472\|gb\|EAA28907.1\| co...	3.0E-49	[4..185]	[1..193]
gi\|27803023, gi\|... - gi\|27803023\|emb\|CAD60726.1\| unnamed protein product [Podospora anserina], gi\|188219265\|emb\|CAP49245.... gi\|189091824 - gi\|189091824\|ref\|XP_001929745.1\| [Podospora anserina]	3.0E-45	[37..180]	[27..165]
gi\|220947962 - gi\|220947962\|gb\|ACL86524.1\| CG12534-PA [synthetic construct] gi\|24643392, gi\|... - gi\|24643392\|ref\|NP_608353.1\| CG12534-PA [Drosophila melanogaster], gi\|22832612\|gb\|AAF49017.2\| CG1253...	1.0E-42	[40..180]	[47..189]
gi\|7576256 - gi\|7576256\|emb\|CAB87993.1\| augmenter of liver regeneration [Homo sapiens]	3.0E-42	[63..180]	[88..200]
ALR_MOUSE - FAD-linked sulfhydryl oxidase ALR OS=Mus musculus GN=Gfer PE=1 SV=2	7.0E-42	[63..180]	[82..194]
gi\|21555659 - gi\|21555659\|gb\|AAM63908.1\| unknown [Arabidopsis thaliana]	1.0E-41	[59..188]	[56..183]

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Predicted Domain #1

Region A:
Residues: [1-196]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQIVKRSHA IRIVAALGII GLWMFFSSNE LSIATPGLIK AKSGIDEVQG AAAEKNDARL  60
   61 KEIEKQTIMP LMGDDKVKKE VGRASWKYFH TLLARFPDEP TPEEREKLHT FIGLYAELYP 120
  121 CGECSYHFVK LIEKYPVQTS SRTAAAMWGC HIHNKVNEYL KKDIYDCATI LEDYDCGCSD 180
  181 SDGKRVSLEK EAKQHG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	709.0103
Match:	1jr8A_
Description:	Thiol oxidase Erv2p
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
thiol oxidase activity	4.3254249879943	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor	3.98547172748427	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	3.58586994168694	bayes_pls_golite062009
flavin-linked sulfhydryl oxidase activity	1.63885808871496	bayes_pls_golite062009
binding	0.709753727419316	bayes_pls_golite062009
protein binding	0.661894111825388	bayes_pls_golite062009
catalytic activity	0.620866037386174	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: