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View Structure Prediction Details

Protein: APL4
Organism: Saccharomyces cerevisiae
Length: 832 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APL4.

Description E-value Query
Range
Subject
Range
gi|56744242, gi|... - gi|56744242|ref|NP_033807.2| adaptor protein complex AP-1, gamma 1 subunit [Mus musculus], gi|324516...
0.0 [3..825] [5..817]
AP1G1 - adaptor-related protein complex 1, gamma 1 subunit
0.0 [3..825] [5..814]
gi|28838736, gi|... - gi|41054423|ref|NP_955976.1| adaptor-related protein complex 1, gamma 1 subunit [Danio rerio], gi|28...
0.0 [3..825] [5..811]
gi|28277340 - gi|28277340|gb|AAH45070.1| Wu:fc30a11 protein [Xenopus laevis]
0.0 [3..825] [11..813]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [5..832] [13..822]

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Predicted Domain #1
Region A:
Residues: [1-104]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSSLRSFIK DVRGAKTLAD ERAIITKQSA KIRTKLRDDH LPHEKRRVNI QKLLYLYILG  60
   61 EKTHFGQVES INLIASDDFV DKRLGYLAAT LLLDESEDLL TLLT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 402.9897
Match: 1gw5A_
Description: Adaptin alpha C subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [105-178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NMLNNDLHHP NKYAVSLALT SLGFLSSPEL ARDLYPDVEN IIKNSRDPFL LKKALQCAAK  60
   61 LIFKDVSLLE IFNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 402.9897
Match: 1gw5A_
Description: Adaptin alpha C subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.57801165255065 bayes_pls_golite062009
binding 1.4853299341494 bayes_pls_golite062009
transporter activity 1.4237388137024 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [179-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDITKILSSH SICTHGVLLG VTKIIQSILL IGLNRKKDED EDEDGIDYSN DILSPLSLLL  60
   61 RDFFIRLENM NSKNIEPGYD VQGICDPFLQ CEIIYTLKLY FQVGELLNSN NVLDYKDNFC 120
  121 DLLTRIATNT DSTKNSGQAI LYETVKTIFS LDLNQPLRV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 402.9897
Match: 1gw5A_
Description: Adaptin alpha C subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [338-407]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGINILAKFL AGKDNNTKYV SLNTLLKVVP QEPTAVQRHR KFISHCLQDT DVSIRMRALE  60
   61 LSFAILDDSN 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 402.9897
Match: 1gw5A_
Description: Adaptin alpha C subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [408-534]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVELVNELMK FLAKQDEDSK DLIIYTIDHL IDTFDTRVVK DESWKLDVFF NILKLVGSFI  60
   61 NYEKINDILI IINNTSQLSD KSEFLRKMLT ISLNGTSAEI SEENIGWQLV LIWCIGEYGD 120
  121 LVLNEGN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 402.9897
Match: 1gw5A_
Description: Adaptin alpha C subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [535-688]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNGADIINES SITDYLLTLQ ELYTATNLKI INYILTAALK LSVRFHDAKN IEKLRQLILS  60
   61 YTDSTDLSLQ MKSNQYEIFF NQSISVKKII LETMPKFEKI TEEQDNGKAL SKNLISNEPV 120
  121 DLLSDLLGED SKAESKASTG DNVKPIDILE EIFG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [689-832]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKNDIAQVPK NANKEESINH SSAVEANSGV TLPLDANKIY DSSSLNVYAS LLSANSGLAH  60
   61 LDLYFQAKSL ISDLKTFCAV PKAQKLTLGQ LYPSSTINAS QICKQSLKIS GSGKLKLRVK 120
  121 LDFHLNGSSS ITNEQFDHKF DETL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.0
Match: 1iu1A_
Description: Gamma1-adaptin domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle