YRC Public Data Repository - Protein Structure Prediction

Protein:	CTI6
Organism:	Saccharomyces cerevisiae
Length:	506 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CTI6.

Description	E-value	Query Range	Subject Range
CG13185-PB - This gene is referred to in FlyBase by the symbol Dmel\CG13185 (CG13185, FBgn0033661). It is a prote...	1.0E-62	[4..490]	[4376..4886]
gi\|190407780 - gi\|190407780\|gb\|EDV11045.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] CTI6_YEAST - Histone deacetylase complex subunit CTI6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... CTI6 - Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recru... gi\|151942618 - gi\|151942618\|gb\|EDN60964.1\| cyc8-tup1 interacting protein [Saccharomyces cerevisiae YJM789]	2.0E-52	[1..506]	[1..506]
GERIA_BACCE - Spore germination protein GerIA OS=Bacillus cereus GN=gerIA PE=3 SV=1 gi\|229193019, gi... - gi\|229193019\|ref\|ZP_04319975.1\| Spore germination protein gerIA [Bacillus cereus ATCC 10876], gi\|228...	2.0E-44	[195..495]	[8..340]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-43	[2..467]	[22..470]
NFH_MOUSE - (P19246) Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polype...	1.0E-42	[5..483]	[547..1024]
gi\|24020878, gi\|... - gi\|50979202\|ref\|NP_001003352.1\| neurofilament, heavy polypeptide 200kDa [Canis lupus familiaris], gi...	2.0E-41	[2..486]	[487..968]
gi\|30022804, gi\|... - gi\|30022804\|ref\|NP_834435.1\| spore germination protein IA [Bacillus cereus ATCC 14579], gi\|29898363\|... gi\|229130012, gi... - gi\|229130012\|ref\|ZP_04258976.1\| Spore germination protein gerIA [Bacillus cereus BDRD-Cer4], gi\|2286...	4.0E-41	[140..495]	[7..405]
gi\|112044, gi\|26... - gi\|29789026\|ref\|NP_036739.1\| neurofilament, heavy polypeptide [Rattus norvegicus], gi\|2642598\|gb\|AAB...	7.0E-40	[7..473]	[477..936]

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Predicted Domain #1

Region A:
Residues: [1-68]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESTAIVPKG PVVGSEDMEK AEVIASGSTD IISTTSTATT TAAIGSVQEE SVKQEDVPME  60
   61 GGEGEVEE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.281	0.856	positive regulation of transcription	a.4.5	"Winged helix" DNA-binding domain

Predicted Domain #2

Region A:
Residues: [69-127]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEGETRCICG ELDTPDDSGF FIQCEQCSSW QHGYCVSITQ DNAPDKYWCE QCRPELHQL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	14.455932
Match:	PF00628
Description:	PHD-finger

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [128-506]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTTDTGEARS IYKPVQEKRR QSRRKARSAA ASKSHAANEA EKSPRNTSNT DDNVDDIGDE  60
   61 EDEVEDEASA VALAKDGNTR SSRRRRRNSM DDASTDQYSL DPGDSDKKLL DRKRATFMAR 120
  121 EEKQYQRMLE KALKESRRTS HQEDPESYEN DADIYQGDTD NHNGTTRLQT DVMLTEGKPD 180
  181 SVTNDDMKES LRPSKEQSME KTNDVEKEAS QEKESSTGSA QDTEKTDEPI LPLTSISSSE 240
  241 DDSRKASSRG SKRVSKPARK GNRTRRSNTS SDTNQNRRSA DIGTDKPVKP RLPPQRTSLN 300
  301 EMRRRVSAIL EFISRTQWEL SEDQSDREEF VRFVENQHFV EKVDTIYNGY NESLSMMDDL 360
  361 TRELLLWEKK YSNNTNAIQ

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [421-506]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQRTSLNEMR RRVSAILEFI SRTQWELSED QSDREEFVRF VENQHFVEKV DTIYNGYNES  60
   61 LSMMDDLTRE LLLWEKKYSN NTNAIQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.899	a.8.3	Families 57/38 glycoside transferase middle domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits