YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: MEX67
Organism: Saccharomyces cerevisiae
Length: 599 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MEX67.

Description E-value Query
Range		 Subject
Range
NXF1_MOUSE - Nuclear RNA export factor 1 OS=Mus musculus GN=Nxf1 PE=1 SV=2
 5.0E-87 [14..598] [110..618]
NXF1 - nuclear RNA export factor 1
gi|123999198, gi... - gi|123999198|gb|ABM87179.1| nuclear RNA export factor 1 [synthetic construct], gi|123988683|gb|ABM83...
gi|114638083 - gi|114638083|ref|XP_001157986.1| PREDICTED: nuclear RNA export factor 1 isoform 9 [Pan troglodytes]
 2.0E-85 [14..598] [111..619]
NXF1_RAT - Nuclear RNA export factor 1 OS=Rattus norvegicus GN=Nxf1 PE=2 SV=1
 5.0E-85 [14..598] [110..618]
gi|186464136, gi... - gi|23128321|ref|ZP_00110172.1| COG4886: Leucine-rich repeat (LRR) protein [Nostoc punctiforme PCC 73...
 1.0E-77 [4..490] [23..516]

Back

Predicted Domain #1
Region A:
Residues: [1-98] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGFHNVGNI NMMAQQQMQQ NRIKISVRNW QNATMNDLIN FISRNARVAV YDAHVEGPLV  60
   61 IGYVNSKAEA ESLMKWNGVR FAGSNLKFEL LDNNGASA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 118.927757
Match: 1ft8A_
Description: mRNA export factor tap
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 2.45747497442245 bayes_pls_golite062009
transmembrane receptor activity 2.20259885800343 bayes_pls_golite062009
signal transducer activity 2.14481842394036 bayes_pls_golite062009
molecular transducer activity 2.14481842394036 bayes_pls_golite062009
binding 1.87302803330255 bayes_pls_golite062009
structural molecule activity 1.83189461928225 bayes_pls_golite062009
nucleic acid binding 1.5811568573961 bayes_pls_golite062009
G-protein coupled receptor activity 1.43652168420174 bayes_pls_golite062009
cytoskeletal protein binding 1.2741906444944 bayes_pls_golite062009
actin binding 0.666110887282576 bayes_pls_golite062009
protein binding 0.646159692466759 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [99-260] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTSDTISFLR GVLLKRYDPQ TKLLNLGALH SDPELIQKGV FSSISTQSKM FPAMMKLAST  60
   61 EKSLIVESVN LADNQLKDIS AISTLAQTFP NLKNLCLANN QIFRFRSLEV WKNKFKDLRE 120
  121 LLMTNNPITT DKLYRTEMLR LFPKLVVLDN VIVRDEQKLQ TV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 118.927757
Match: 1ft8A_
Description: mRNA export factor tap
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [261-375] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSLPMKIQQF FFENDALGQS STDFATNFLN LWDNNREQLL NLYSPQSQFS VSVDSTIPPS  60
   61 TVTDSDQTPA FGYYMSSSRN ISKVSSEKSI QQRLSIGQES INSIFKTLPK TKHHL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.221849
Match: 1p8tA_
Description: Reticulon 4 receptor (Nogo-66 receptor, Ngr)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleocytoplasmic transporter activity 4.11811310168752 bayes_pls_golite062009
protein transporter activity 3.25560675565407 bayes_pls_golite062009
binding 2.52411158739487 bayes_pls_golite062009
protein transmembrane transporter activity 2.19585939185279 bayes_pls_golite062009
structural constituent of nuclear pore 2.18859566641856 bayes_pls_golite062009
nucleic acid binding 2.1539951593359 bayes_pls_golite062009
transporter activity 1.80701285041353 bayes_pls_golite062009
structural molecule activity 1.60851232976006 bayes_pls_golite062009
mRNA binding 1.48678274024408 bayes_pls_golite062009
protein binding 1.34243535208605 bayes_pls_golite062009
substrate-specific transporter activity 1.33804818542017 bayes_pls_golite062009
transmembrane transporter activity 1.22102896992563 bayes_pls_golite062009
Ran GTPase binding 1.18290069522408 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.890150150408175 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.77053580490303 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.77053580490303 bayes_pls_golite062009
RNA binding 0.47499792472996 bayes_pls_golite062009
primary active transmembrane transporter activity 0.446562877324676 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.439519001457896 bayes_pls_golite062009
active transmembrane transporter activity 0.430285640125175 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [376-445] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEQPNEYSME TISYPQINGF VITLHGFFEE TGKPELESNK KTGKNNYQKN RRYNHGYNST  60
   61 SNNKLSKKSF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.524 a.56.1 CO dehydrogenase ISP C-domain like

Predicted Domain #5
Region A:
Residues: [446-599] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRTWVIVPMN NSVIIASDLL TVRAYSTGAW KTASIAIAQP PQQQASVLPQ VASMNPNITT  60
   61 PPQPQPSVVP GGMSIPGAPQ GAMVMAPTLQ LPPDVQSRLN PVQLELLNKL HLETKLNAEY 120
  121 TFMLAEQSNW NYEVAIKGFQ SSMNGIPREA FVQF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.69897
Match: 1jkgB_
Description: NTF2-like domain of Tip associating protein, TAP
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle