YRC Public Data Repository - Protein Structure Prediction

Protein:	ISU1
Organism:	Saccharomyces cerevisiae
Length:	165 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISU1.

Description	E-value	Query Range	Subject Range
ISU1 - Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of ir... gi\|190407823 - gi\|190407823\|gb\|EDV11088.1\| iron sulfur cluster assembly protein 1, mitochondrial precursor [Sacchar... gi\|151942663 - gi\|151942663\|gb\|EDN61009.1\| iron-sulfur cluster nifu-like protein [Saccharomyces cerevisiae YJM789] ISU1_YEAST - Iron sulfur cluster assembly protein 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 20450...	1.0E-58	[1..165]	[1..165]
gi\|21595581 - gi\|21595581\|gb\|AAM66114.1\| nifU-like protein [Arabidopsis thaliana]	9.0E-52	[4..158]	[1..151]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-51	[15..159]	[10..151]
gi\|33573345 - gi\|33573345\|emb\|CAE37329.1\| [Fe-S] cluster formation/repair protein [Bordetella parapertussis] gi\|33596644 - gi\|33596644\|ref\|NP_884287.1\| scaffold protein [Bordetella parapertussis 12822] gi\|33575695, gi\|... - gi\|33601260\|ref\|NP_888820.1\| scaffold protein [Bordetella bronchiseptica RB50], gi\|33575695\|emb\|CAE3... gi\|33572510, gi\|... - gi\|33592862\|ref\|NP_880506.1\| scaffold protein [Bordetella pertussis Tohama I], gi\|33572510\|emb\|CAE42...	3.0E-51	[33..162]	[1..129]
isu1 - mitochondrial iron-sulfur cluster assembly scaffold protein Isu1 ISU1_SCHPO - Iron sulfur cluster assembly protein 1, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATC...	4.0E-51	[8..161]	[25..179]
gi\|20381021 - gi\|20381021\|gb\|AAH28800.1\| Iscu protein [Mus musculus]	1.0E-50	[5..160]	[8..158]
gi\|11351414 - pir\|\|F83168 probable iron-binding protein IscU PA3813 [imported] - Pseudomonas aeruginosa (strain PA... gi\|194547702, gi... - gi\|84319377\|ref\|ZP_00967774.1\| COG0822: NifU homolog involved in Fe-S cluster formation [Pseudomonas... gi\|94412415, gi\|... - gi\|94412415\|ref\|ZP_01292344.1\| hypothetical protein PaerP_01005780 [Pseudomonas aeruginosa PA7], gi\|... gi\|46164499, gi\|... - gi\|46164499\|ref\|ZP_00137233.2\| COG0822: NifU homolog involved in Fe-S cluster formation [Pseudomonas... gi\|254242504, gi... - gi\|84325542\|ref\|ZP_00973577.1\| COG0822: NifU homolog involved in Fe-S cluster formation [Pseudomonas... gi\|107103333 - gi\|107103333\|ref\|ZP_01367251.1\| hypothetical protein PaerPA_01004402 [Pseudomonas aeruginosa PACS2] gi\|9949987, gi\|1... - gi\|9949987\|gb\|AAG07200.1\|AE004799_6 probable iron-binding protein IscU [Pseudomonas aeruginosa PAO1]... gi\|218770126, gi... - gi\|218889903\|ref\|YP_002438767.1\| scaffold protein [Pseudomonas aeruginosa LESB58], gi\|218770126\|emb\|...	1.0E-50	[33..160]	[1..127]

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Predicted Domain #1

Region A:
Residues: [1-165]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPVITRFAR PALMAIRPVN AMGVLRASSI TKRLYHPKVI EHYTHPRNVG SLDKKLPNVG  60
   61 TGLVGAPACG DVMRLQIKVN DSTGVIEDVK FKTFGCGSAI ASSSYMTELV QGMTLDDAAK 120
  121 IKNTEIAKEL SLPPVKLHCS MLAEDAIKAA IKDYKSKRNT PTMLS

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	83.920819
Match:	PF01592
Description:	NifU-like N terminal domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	1.25897597318598	bayes_pls_golite062009
iron ion binding	0.905595388647019	bayes_pls_golite062009
protein binding	0.257846679116775	bayes_pls_golite062009
catalytic activity	0.256292883613773	bayes_pls_golite062009
transition metal ion binding	0.192770514366253	bayes_pls_golite062009
2 iron, 2 sulfur cluster binding	0.0439466134407704	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: