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View Structure Prediction Details

Protein: SYH1
Organism: Saccharomyces cerevisiae
Length: 849 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SYH1.

Description E-value Query
Range
Subject
Range
SYH1 - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; ...
SYH1_YEAST - SMY2 homolog 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SYH1 PE=1 SV=1
0.0 [1..849] [1..849]
gi|28564165 - gi|28564165|gb|AAO32461.1| YPL105C [Saccharomyces servazzii]
5.0E-64 [3..841] [16..882]
gi|28564099 - gi|28564099|gb|AAO32428.1| YPL105C [Saccharomyces bayanus]
7.0E-48 [1..426] [1..412]
gi|24020878, gi|... - gi|50979202|ref|NP_001003352.1| neurofilament, heavy polypeptide 200kDa [Canis lupus familiaris], gi...
6.0E-45 [35..748] [412..1135]
gi|7549210 - gi|7549210|gb|AAF63787.1|AF142406_1 200 kDa antigen p200 [Babesia bigemina]
4.0E-37 [183..741] [186..731]
gi|124802937, gi... - gi|23508159|ref|NP_700829.1| liver stage antigen, putative [Plasmodium falciparum 3D7], gi|23495223|...
4.0E-36 [31..756] [237..968]
NFH_MOUSE - (P19246) Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polype...
7.0E-36 [10..679] [435..1084]
MYH1_PIG - Myosin-1 OS=Sus scrofa GN=MYH1 PE=2 SV=1
9.0E-36 [152..739] [835..1422]
MYH1_HORSE - Myosin-1 OS=Equus caballus GN=MYH1 PE=2 SV=1
1.0E-35 [152..739] [834..1421]

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Predicted Domain #1
Region A:
Residues: [1-143]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNPINSLAFD LHSVKLADAN SDTAALSNSN TPTMNNAALL QRPSSIMDSI GVQRVPSPFV  60
   61 PGSNAISGAS TVPFNAYDAE ITGSPLQISA NQENNSAFSA ASSNLHMNAS SPSVLNKPSS 120
  121 TFPNVAPYLY NATGPAPNVG NQP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [144-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPGIESQWK YIDSNGNIQG PFGTNNMSQW YQGGYFTPTL QICRLATSPE PFGVNDRFIR  60
   61 LGELTTLVNN YQDPFVAFDF IVIRALN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 26.920819
Match: PF02213
Description: GYF domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.620582218767 bayes_pls_golite062009
protein binding 0.648944095180566 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [231-590]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVPLVAPTSS EKQKVESRDL IPVADVHSDD FTYEEILGLK FEDGSYYHET QVWVPVDGRH  60
   61 ITKVDRIPKI SAYTAPLSTT SSRSNKTTSS HEEKVPSHEE ASPEEQEVFS EEGRTVSNIT 120
  121 NEEESIVKNP TKQEEESRGS EKEQNILDQV QPEIEEVDRK DVISTADEPK SKDTPQMTSE 180
  181 EQKRFAKAEL MAQKLLEEQQ RQEEEKKRRE EQRKLKKEKK LKQKQKKEEE KLKKKKKEEG 240
  241 KLEKEKQKEL LNNILTGDTE TPSSENTATS ITTNLAPWAN KKPEGAVYNQ ISSALEDLKK 300
  301 ENSSKKEKKP NRTQLDREQA LKLQKEILSS AQIPKTQTGS AWGIKPQQPI KVDIKGELMK 360
  361 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.457575
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [591-849]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSTKINSQSK INKANNGDIK PDSTFIEEQK KLWEQVQKKT KKFNRASSLD DFISRTPSPS  60
   61 SSALNSSNTS NAWTTVSSKS TTHIASTMPV AGNQSKSYIS LDTLRSSGGL STATKTKMSD 120
  121 KSKQIGSSTS IPTLKARQVK PSRIPAYPGN ASVSKRQEFL RWCRSQLKLN TGVQPDNVLE 180
  181 MLLSLPPGSE SKEIIADTIY SYSSTMDGRR FATDFIKKRL ECEEEINDPL SWSEVLAMPE 240
  241 GSSEDWEFQV VGKKKGKRF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle