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View Structure Prediction Details

Protein: SEN54
Organism: Saccharomyces cerevisiae
Length: 467 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEN54.

Description E-value Query
Range
Subject
Range
SEN54 - Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
SEN54_YEAST - tRNA-splicing endonuclease subunit SEN54 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
0.0 [1..467] [1..467]
SEN54_SCHPO - Probable tRNA-splicing endonuclease subunit sen54 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24...
sen54 - tRNA-splicing endonuclease subunit Sen54
0.0 [9..342] [2..318]
SE54_NEUCR, SEN5... - Probable tRNA-splicing endonuclease subunit sen-54 OS=Neurospora crassa GN=sen-54 PE=3 SV=1, (Q7SC91...
SEN54_NEUCR - Probable tRNA-splicing endonuclease subunit sen-54 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23...
4.0E-96 [18..451] [34..506]
gi|31565520 - gi|31565520|gb|AAH53643.1| TSEN54 protein [Homo sapiens]
7.0E-57 [33..202] [22..178]
gi|26354132 - gi|26354132|dbj|BAC40696.1| unnamed protein product [Mus musculus]
3.0E-54 [33..290] [18..243]
CG5626-PA - This gene is referred to in FlyBase by the symbol Dmel\CG5626 (CG5626, FBgn0036266). It is a protein...
6.0E-43 [19..335] [4..354]
gi|6735315, gi|1... - gi|6735315|emb|CAB68142.1| hypothetical protein [Arabidopsis thaliana], gi|15230281|ref|NP_191295.1|...
1.0E-38 [86..317] [38..193]

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Predicted Domain #1
Region A:
Residues: [1-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQFAGKKTDQ VTTSNPGFEE EEEEEEELQQ DWSQLASLVS KNAALSLPKR GEKDYEPDGT  60
   61 NLQDLLLYNA SKAMFDTISD SIRGTTVKSE VRGYYVPHKH QAVLLKPKGS FMQTMGRADS 120
  121 TGELWLDFHE FVYLAERGTI LPYYRLEAGS NKSSKHETEI LLSMEDLYSL FSSQQEMDQY 180
  181 FVFAHLKRLG FILKPSNQEA AVKTSFFPLK KQRSNLQAIT WRLLSLFKIQ ELSLFSGFFY 240
  241 SKWNFFFRKY TTSPQLYQGL NRLVRSVAVP KNKKELLDAQ SDREFQKVKD IPLTFKVWKP 300
  301 HSNFKKRDPG LPDFQVFVYN KNDDLQHFPT YKELRSMFSS LDYKFEFLSE IEDDDDWETN 360
  361 SYVEDIPRKE YIHKRSAKSQ T

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.462 N/A N/A a.74.1 Cyclin-like
View Download 0.371 N/A N/A a.74.1 Cyclin-like
View Download 0.282 N/A N/A a.74.1 Cyclin-like
View Download 0.271 N/A N/A d.141.1 Ribosomal protein L6
View Download 0.268 N/A N/A a.142.1 PTS-regulatory domain, PRD

Predicted Domain #2
Region A:
Residues: [382-467]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKSESSMKAS FQKKTAQSST KKKRKAYPPH IQQNRRLKTG YRSFIIAIMD NGLISFVKMS  60
   61 EADFGSESVW YTPNTQKKVD QRWKKH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.538 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.652 d.95.2 Homing endonucleases
View Download 0.582 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.509 d.52.1 Alpha-lytic protease prodomain
View Download 0.461 a.59.1 PAH2 domain
View Download 0.438 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.416 d.88.1 SRF-like
View Download 0.411 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.385 g.14.1 Kringle-like
View Download 0.373 b.7.2 Periplasmic chaperone C-domain
View Download 0.359 d.58.7 RNA-binding domain, RBD
View Download 0.322 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.312 d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.306 a.47.2 t-snare proteins
View Download 0.296 d.58.7 RNA-binding domain, RBD
View Download 0.270 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.270 d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.266 d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.250 d.95.2 Homing endonucleases
View Download 0.245 d.58.4 Dimeric alpha+beta barrel
View Download 0.226 f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.216 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.212 d.81.1 Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
View Download 0.203 a.60.7 5' to 3' exonuclease, C-terminal subdomain

Predicted Domain #3
Region A:
Residues: [207-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPLKKQRSNL QAITWRLLSL FKIQELSLFS GFFYSKWNFF FRKYTTSPQL YQGLNRLVRS  60
   61 VAVPKNKKEL LDAQSDREFQ KVKDIPLTFK VWKPHSNFKK RDPGLPDFQV FVYNKNDDLQ 120
  121 HF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.417 c.3.1 FAD/NAD(P)-binding domain
View Download 0.416 a.118.8 TPR-like
View Download 0.380 a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.329 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.280 a.73.1 Retrovirus capsid protein, N-terminal core domain

Predicted Domain #4
Region A:
Residues: [329-467]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTYKELRSMF SSLDYKFEFL SEIEDDDDWE TNSYVEDIPR KEYIHKRSAK SQTEKSESSM  60
   61 KASFQKKTAQ SSTKKKRKAY PPHIQQNRRL KTGYRSFIIA IMDNGLISFV KMSEADFGSE 120
  121 SVWYTPNTQK KVDQRWKKH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.661 d.95.2 Homing endonucleases
View Download 0.652 d.95.2 Homing endonucleases
View Download 0.587 d.95.2 Homing endonucleases
View Download 0.582 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.542 d.95.2 Homing endonucleases


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