YRC Public Data Repository - Protein Structure Prediction

Protein:	CWC27
Organism:	Saccharomyces cerevisiae
Length:	301 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CWC27.

Description	E-value	Query Range	Subject Range
CWC27_YEAST - Peptidyl-prolyl isomerase CWC27 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CWC27 PE... CWC27 - Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to...	1.0E-76	[1..301]	[1..301]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	4.0E-71	[5..301]	[7..322]
CPY57_ARATH - Peptidyl-prolyl cis-trans isomerase CYP57 OS=Arabidopsis thaliana GN=CYP57 PE=1 SV=1	3.0E-68	[5..301]	[7..322]
CWC27_NEUCR - Peptidyl-prolyl isomerase cwc-27 OS=Neurospora crassa GN=cwc-27 PE=3 SV=1 CWC27_NEUCR - Peptidyl-prolyl isomerase cwc-27 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 /...	5.0E-64	[1..301]	[1..367]
cyp7 - cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp7 CYP7_SCHPO - Peptidylprolyl isomerase cyp7 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cyp7 PE=1 SV...	1.0E-63	[3..298]	[5..374]
CG10907-PA - This gene is referred to in FlyBase by the symbol Dmel\CG10907 (CG10907, FBgn0036207). It is a prote... gi\|220957050, gi... - gi\|220957050\|gb\|ACL91068.1\| CG10907-PA [synthetic construct], gi\|220947834\|gb\|ACL86460.1\| CG10907-PA...	7.0E-63	[6..297]	[8..345]
gi\|82491991 - gi\|82491991\|gb\|ABB77877.1\| peptidylprolyl isomerase A [Gorilla gorilla] PPIA_HYLLA - Peptidyl-prolyl cis-trans isomerase A OS=Hylobates lar GN=PPIA PE=3 SV=3 PPIA_NOMLE - Peptidyl-prolyl cis-trans isomerase A OS=Nomascus leucogenys GN=PPIA PE=3 SV=3 PPIA_SYMSY - Peptidyl-prolyl cis-trans isomerase A OS=Symphalangus syndactylus GN=PPIA PE=3 SV=3 PPIA_GORGO - Peptidyl-prolyl cis-trans isomerase A OS=Gorilla gorilla gorilla GN=PPIA PE=3 SV=3 PPIA_PAPAN - Peptidyl-prolyl cis-trans isomerase A OS=Papio anubis GN=PPIA PE=2 SV=2 gi\|2565299 - gi\|2565299\|gb\|AAB81959.1\| cyclophilin A [Papio hamadryas] gi\|208967012, gi... - gi\|208967012\|dbj\|BAG73520.1\| peptidylprolyl isomerase A [synthetic construct], gi\|123998379\|gb\|ABM86... PPIA_CHLAE - Peptidyl-prolyl cis-trans isomerase A OS=Chlorocebus aethiops GN=PPIA PE=2 SV=2 gi\|90075960 - gi\|90075960\|dbj\|BAE87660.1\| unnamed protein product [Macaca fascicularis] PPIA - peptidylprolyl isomerase A (cyclophilin A) PPIA_MACMU - Peptidyl-prolyl cis-trans isomerase A OS=Macaca mulatta GN=PPIA PE=1 SV=2 gi\|31615579, gi\|... - gi\|31615580\|pdb\|1M9Y\|F Chain F, X-Ray Crystal Structure Of Cyclophilin AHIV-1 Ca N- Terminal Domain ... PPIA_PANPA - Peptidyl-prolyl cis-trans isomerase A OS=Pan paniscus GN=PPIA PE=3 SV=3 PPIA_PANTR - Peptidyl-prolyl cis-trans isomerase A OS=Pan troglodytes GN=PPIA PE=3 SV=3 PPIA_PONPY - Peptidyl-prolyl cis-trans isomerase A OS=Pongo pygmaeus GN=PPIA PE=2 SV=4	7.0E-63	[8..155]	[1..165]

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Predicted Domain #1

Region A:
Residues: [1-197]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNIEPQTT AKCILYTTKG NIAIELWAKE CPETCKRFLS MLSDGTFTNG EFKELKPTQW  60
   61 LMFNANSTGE YRTVAEEKNP RIRFNRDGLL GWDRRRNTWF ITVLADSKHV LNDCNVFGKI 120
  121 VGKSIYIFRE ILGGEIEASS RDNDVKRFMY PAVLKDVEIT IPFFEDIFGS KRRLEDNEKK 180
  181 EQEPAKKLVK SAKVKMV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.69897
Match:	1ak4A_
Description:	Cyclophilin (eukaryotic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.748655649755714	bayes_pls_golite062009
binding	0.508724818609046	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [198-301]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEDEQEDDDG DVQKLKPRKR MILPAWIKDD SRSEGIKLDA SLDQPQEALI REKTELHDNV  60
   61 DEATTKETES QENIKEEPMD KRERETLAML SKFQERIKNK NILK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: