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View Structure Prediction Details

Protein: NOP4
Organism: Saccharomyces cerevisiae
Length: 685 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOP4.

Description E-value Query
Range
Subject
Range
gi|521090 - gi|521090|emb|CAA53824.1| NOP77p [Saccharomyces cerevisiae]
gi|151942750 - gi|151942750|gb|EDN61096.1| nucleolar protein [Saccharomyces cerevisiae YJM789]
434.0 [0..1] [685..1]
gi|73974146 - gi|73974146|ref|XP_857039.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
415.0 [0..280] [685..1]
PABP1_BOVIN - Polyadenylate-binding protein 1 OS=Bos taurus GN=PABPC1 PE=2 SV=1
gi|109087089 - gi|109087089|ref|XP_001098239.1| PREDICTED: poly(A) binding protein, cytoplasmic 1 isoform 2 [Macaca...
gi|123993665, gi... - gi|168278070|dbj|BAG11013.1| polyadenylate-binding protein 1 [synthetic construct], gi|123999981|gb|...
gi|194036975 - gi|194036975|ref|XP_001927782.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-bind...
PABPC1 - poly(A) binding protein, cytoplasmic 1
gi|73974130, gi|... - gi|73974178|ref|XP_857695.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
413.0 [0..280] [685..1]
PABP1_MOUSE - Polyadenylate-binding protein 1 OS=Mus musculus GN=Pabpc1 PE=1 SV=2
413.0 [0..280] [685..1]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEETIENVEV PSSNVSKQND DGLDMKTLFV RSIPQDVTDE QLADFFSNFA PIKHAVVVKD  60
   61 TNKRSRGFGF VSFAVEDDTK EALAKARKTK FNGHILRVDI AKRRDRSKKT SEVVEKSTPE 120
  121 SSE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.264245
Match: 1l3kA
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [124-255]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KITGQNNEDE DDADGEDSML KGKPKLIIRN MPWSCRDPVK LKKIFGRYGT VVEATIPRKR  60
   61 DGKLCGFAFV TMKKISNCRI ALENTKDLKI DGRKVAVDFA VQKNRWEDYK KAQPEMNDKD 120
  121 DNESGNEDAE EN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.264245
Match: 1l3kA
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [256-383]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDDEEDENEE EDRQVDQASK NKESKRKAQN KREDFSVFVR NVPYDATEES LAPHFSKFGS  60
   61 VKYALPVIDK STGLAKGTAF VAFKDQYTYN ECIKNAPAAG STSLLIGDDV MPEYVYEGRV 120
  121 LSITPTLV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.927757
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [384-500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 REDAGRMAEK NAAKRKEALG KAPGEKDRRN LYLLNEGRVV EGSKMADLLT NTDMEIREKS  60
   61 YKLRVEQLKK NPSLHLSMTR LAIRNLPRAM NDKALKALAR KAVVEFATEV KNKERHP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 76.927757
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [501-633]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSKEEIIRST KEKYKFMGPD EIEAQKKKDK KSGVVKQAKV IMEVKGSTAG RSRGYGFVEF  60
   61 RDHKNALMGL RWLNCHAVTS DEILEGLNDD EKKQVDNDLG KGRRLCVEFA IENSNVVKRR 120
  121 REQLKQARTK RTR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.232149
Match: 1po6A
Description: Crystal Structure of UP1 Complexed With d(TAGG(6MI)TTAGGG): A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6MI)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [634-685]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDNEDTGDVG ESENKKPKKE EATTPTNPDD KKMGDDIKRI IGFKRKRKHA KK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.271 a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.233 d.48.1 RecA protein, C-terminal domain
View Download 0.232 a.159.2 FF domain
View Download 0.215 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.215 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle