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View Structure Prediction Details

Protein: PRO2
Organism: Saccharomyces cerevisiae
Length: 456 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRO2.

Description E-value Query
Range
Subject
Range
AL1A1_SHEEP - Retinal dehydrogenase 1 OS=Ovis aries GN=ALDH1A1 PE=1 SV=2
0.0 [3..430] [59..498]
AL1A1_CHICK - Retinal dehydrogenase 1 OS=Gallus gallus GN=ALDH1A1 PE=2 SV=1
0.0 [2..430] [66..506]
AL1A1_RABIT - Retinal dehydrogenase 1 OS=Oryctolagus cuniculus GN=ALDH1A1 PE=2 SV=1
0.0 [2..430] [53..493]
AL1A1_BOVIN - Retinal dehydrogenase 1 - Bos taurus (Bovine)
0.0 [3..430] [59..498]
AL1A1_MACFA - Retinal dehydrogenase 1 OS=Macaca fascicularis GN=ALDH1A1 PE=2 SV=3
0.0 [2..430] [58..498]
gi|2183299 - gi|2183299|gb|AAC51652.1| aldehyde dehydrogenase 1 [Homo sapiens]
0.0 [3..430] [59..498]
gi|60653829, gi|... - gi|60653831|gb|AAX29608.1| aldehyde dehydrogenase 1 family member A1 [synthetic construct], gi|60653...
0.0 [3..430] [59..498]
gi|4586546 - gi|4586546|dbj|BAA76412.1| aldehyde dehydrogenase class 1 [Xenopus laevis]
0.0 [3..430] [60..499]
gi|9755362 - gi|9755362|gb|AAB32754.2| acetaldehyde dehydrogenase; ALDH [Mus musculus]
0.0 [2..430] [58..498]

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Predicted Domain #1
Region A:
Residues: [1-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSQQIAKN ARKAGNILKT ISNEGRSDIL YKIHDALKAN AHAIEEANKI DLAVAKETGL  60
   61 ADSLLKRLDL FKGDKFEVML QGIKDVAELE DPVGKVKMAR ELDDGLTLYQ VTAPVGVLLV 120
  121 IFESRPEVIA NITALSIKSG NAAILKGGKE SVNTFREMAK IVNDTIAQFQ SETGVPVGSV 180
  181 QLIETRQDVS DLLDQDEYID LVVPRGSNAL VRKIKDTTKI PVLGHA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [391-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFRYGFGAEV GISTSKIHAR GPVGLDGLVS YQYQIRGDGQ VASDYLGAGG NKAFVHKDLD  60
   61 IKTVTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 824.0103
Match: 1o20A_
Description: Gamma-glutamyl phosphate reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
glutamate-5-semialdehyde dehydrogenase activity 3.27180265380824 bayes_pls_golite062009
catalytic activity 2.80804701752928 bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity 2.65686856100363 bayes_pls_golite062009
oxidoreductase activity 2.31275077585879 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 2.24875477727877 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 2.22720948878196 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 1.6559690223037 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 1.40606039383065 bayes_pls_golite062009
binding 1.06673666884196 bayes_pls_golite062009
histidinol dehydrogenase activity 0.258030369394064 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [227-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGICSIYLDE DADLIKAKRI SLDAKTNYPA GCNAMETLLI NPKFSKWWEV LENLTLEGGV  60
   61 TIHATKDLKT AYFDKLNELG KLTEAIQCKT VDADEEQDFD KEFLSLDLAA KFVTSTESAI 120
  121 QHINTHSSRH TDAIVTENKA NAEKFMKGVD SSGVYWNAST RFAD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 824.0103
Match: 1o20A_
Description: Gamma-glutamyl phosphate reductase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle