YRC Public Data Repository - Protein Structure Prediction

Protein:	MCH5
Organism:	Saccharomyces cerevisiae
Length:	521 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCH5.

Description	E-value	Query Range	Subject Range
MCH5 - Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-depen...	2.0E-87	[1..521]	[1..521]
gi\|229894922, gi... - gi\|229894922\|ref\|ZP_04510100.1\| putative integral membrane protein [Yersinia pestis Pestoides A], gi... gi\|229694002, gi... - gi\|229897665\|ref\|ZP_04512821.1\| putative integral membrane protein [Yersinia pestis biovar Orientali... gi\|229688600, gi... - gi\|229898310\|ref\|ZP_04513457.1\| putative integral membrane protein [Yersinia pestis biovar Orientali... gi\|167056164, gi... - gi\|167424977\|ref\|ZP_02316730.1\| transporter, major facilitator family [Yersinia pestis biovar Mediae... gi\|166962059, gi... - gi\|167420364\|ref\|ZP_02312117.1\| transporter, major facilitator family [Yersinia pestis biovar Orient... gi\|167467739 - gi\|167467739\|ref\|ZP_02332443.1\| transporter, major facilitator family protein [Yersinia pestis FV-1] gi\|165913807, gi... - gi\|89102527\|ref\|ZP_01175154.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|166010770, gi... - gi\|166010770\|ref\|ZP_02231668.1\| transporter, major facilitator family [Yersinia pestis biovar Antiqu... gi\|108807591, gi... - gi\|108807591\|ref\|YP_651507.1\| putative integral membrane protein [Yersinia pestis Antiqua], gi\|10877... gi\|165920648, gi... - gi\|165927382\|ref\|ZP_02223214.1\| transporter, major facilitator family [Yersinia pestis biovar Orient... gi\|108811867, gi... - gi\|229902169\|ref\|ZP_04517290.1\| putative integral membrane protein [Yersinia pestis Nepal516], gi\|22... gi\|167049621, gi... - gi\|167400768\|ref\|ZP_02306274.1\| transporter, major facilitator family [Yersinia pestis biovar Antiqu... gi\|166208316, gi... - gi\|166211136\|ref\|ZP_02237171.1\| transporter, major facilitator family [Yersinia pestis biovar Antiqu... gi\|25510657 - pir\|\|AG0272 probable integral membrane protein YPO2237 [imported] - Yersinia pestis (strain CO92) gi\|149292257, gi... - gi\|149365844\|ref\|ZP_01887879.1\| putative integral membrane protein [Yersinia pestis CA88-4125], gi\|1... gi\|45441835, gi\|... - gi\|45441835\|ref\|NP_993374.1\| putative integral membrane protein [Yersinia pestis biovar Microtus str... gi\|77636254, gi\|... - gi\|77636254\|ref\|ZP_00798330.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|145209891, gi... - gi\|145598195\|ref\|YP_001162271.1\| integral membrane protein [Yersinia pestis Pestoides F], gi\|1452098... gi\|22125968, gi\|... - gi\|22125968\|ref\|NP_669391.1\| transport protein [Yersinia pestis KIM], gi\|21958911\|gb\|AAM85642.1\|AE01... gi\|16122465, gi\|... - gi\|218929333\|ref\|YP_002347208.1\| putative integral membrane protein [Yersinia pestis CO92], gi\|16122...	2.0E-73	[84..514]	[1..434]
gi\|254691421 - gi\|254691421\|ref\|ZP_05154675.1\| General substrate transporter [Brucella abortus bv. 6 str. 870] gi\|254698379 - gi\|254698379\|ref\|ZP_05160207.1\| General substrate transporter [Brucella abortus bv. 2 str. 86/8/59] gi\|254695281 - gi\|254695281\|ref\|ZP_05157109.1\| General substrate transporter [Brucella abortus bv. 3 str. Tulya] gi\|254706302 - gi\|254706302\|ref\|ZP_05168130.1\| General substrate transporter [Brucella pinnipedialis M163/99/10] gi\|254702566 - gi\|254702566\|ref\|ZP_05164394.1\| General substrate transporter [Brucella suis bv. 3 str. 686] gi\|163675059, gi... - gi\|163844336\|ref\|YP_001621991.1\| hypothetical protein BSUIS_B0147 [Brucella suis ATCC 23445], gi\|163... gi\|254731824 - gi\|254731824\|ref\|ZP_05190402.1\| General substrate transporter [Brucella abortus bv. 4 str. 292] gi\|254711405 - gi\|254711405\|ref\|ZP_05173216.1\| General substrate transporter [Brucella pinnipedialis B2/94] gi\|83269085 - gi\|83269085\|ref\|YP_418376.1\| major facilitator transporter [Brucella melitensis biovar Abortus 2308] gi\|62317093, gi\|... - gi\|62317093\|ref\|YP_222946.1\| phthalate transporter [Brucella abortus bv. 1 str. 9-941], gi\|62197286\|... gi\|82939359 - gi\|82939359\|emb\|CAJ12306.1\| General substrate transporter:Major facilitator superfamily (MFS) [Bruce... gi\|189020933, gi... - gi\|189022359\|ref\|YP_001932100.1\| General substrate transporter [Brucella abortus S19], gi\|189020933\|... gi\|23463482, gi\|... - gi\|23499906\|ref\|NP_699346.1\| phthalate transporter, putative [Brucella suis 1330], gi\|23463482\|gb\|AA...	2.0E-70	[84..514]	[1..431]
gi\|17989441, gi\|... - gi\|17989441\|ref\|NP_542074.1\| putative tartrate transporter [Brucella melitensis 16M], gi\|17985319\|gb... gi\|25526293 - pir\|\|AG3646 probable tartrate transporter BMEII1096 [imported] - Brucella melitensis (strain 16M)	2.0E-69	[72..514]	[12..449]
gi\|26990311, gi\|... - gi\|26990311\|ref\|NP_745736.1\| d-galactonate transporter [Pseudomonas putida KT2440], gi\|24985265\|gb\|A... tr\|I7BRN4\|I7BRN4... - D-galactonate transporter OS=Pseudomonas putida (strain DOT-T1E) GN=gudP PE=4 SV=1 gi\|82735133, gi\|... - gi\|82735133\|ref\|ZP_00897996.1\| D-galactonate transporter [Pseudomonas putida F1], gi\|82717808\|gb\|EAP...	6.0E-68	[99..519]	[3..433]
gi\|12658422 - gi\|12658422\|gb\|AAK01131.1\|AF331922_2 putative hexuronate transporter [Xanthomonas oryzae pv. oryzae]	1.0E-67	[29..518]	[6..484]
PCAK_ACIAD - 4-hydroxybenzoate transporter PcaK OS=Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) GN=pca...	2.0E-67	[74..493]	[2..434]
gi\|28871682, gi\|... - gi\|28871682\|ref\|NP_794301.1\| major facilitator superfamily transporter phthalate permease [Pseudomon... tr\|Q87WJ8\|Q87WJ8... - MFS transporter, phthalate permease family OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=PSP... gi\|213966707, gi... - gi\|213966707\|ref\|ZP_03394858.1\| MFS transporter, phthalate permease family [Pseudomonas syringae pv....	2.0E-67	[101..518]	[5..439]
gi\|114644071, gi... - gi\|114644071\|ref\|XP_001166730.1\| PREDICTED: solute carrier family 16, member 7 isoform 3 [Pan troglo... gi\|123996165, gi... - gi\|123996165\|gb\|ABM85684.1\| solute carrier family 16, member 7 (monocarboxylic acid transporter 2) [... gi\|21265165, gi\|... - gi\|24431958\|ref\|NP_004722.2\| solute carrier family 16, member 7 [Homo sapiens], gi\|21265165\|gb\|AAH30...	7.0E-66	[88..515]	[2..430]

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Predicted Domain #1

Region A:
Residues: [1-82]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDSLTPKD TIVPEEQTNQ LRQPDLDEDS IHYDPEADDL ESLETTASYA STSVSAKVYT  60
   61 KKEVNKGTDI ESQPHWGENT SS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.610	a.77.1	DEATH domain
View	Download	0.358	d.95.2	Homing endonucleases
View	Download	0.451	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.315	a.5.6	Hypothetical protein MTH1615
View	Download	0.610	a.77.1	DEATH domain
View	Download	0.459	a.77.1	DEATH domain
View	Download	0.459	a.77.1	DEATH domain
View	Download	0.451	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.358	d.95.2	Homing endonucleases
View	Download	0.315	a.5.6	Hypothetical protein MTH1615
View	Download	0.300	c.47.1	Thioredoxin-like
View	Download	0.291	g.57.1	Serine proteinase inhibitor lekti
View	Download	0.250	a.4.8	Ribosomal protein S18
View	Download	0.219	d.79.3	L30e-like
View	Download	0.214	a.118.1	ARM repeat
View	Download	0.213	d.95.2	Homing endonucleases
View	Download	0.207	a.39.1	EF-hand
View	Download	0.204	d.68.4	YhbY-like

Predicted Domain #2

Region A:
Residues: [83-521]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 THDSDKEEDS NEEIESFPEG GFKAWVVTFG CFLGLIACFG LLNSTGVIES HLQDNQLSSE  60
   61 SVSTIGWLFS LFLFVCSASC IISGTYFDRN GFRTIMIVGT VFHVAGLFAT ANSTKYWHFI 120
  121 LSFAIVCGFG NGIVLSPLVS VPAHYFFKRR GTALAMATIG GSVGGVVFPI MLRSFFSMKS 180
  181 DTDPTYGFVW GIRTLGFLDL ALLTLSIILV KERLPHVIEN SKDGESRWRY ILRVYILQCF 240
  241 DAKAFLDMKY LFCVLGTVFS ELSINSALTY YGSYATSHGI SANDAYTLIM IINVCGIPGR 300
  301 WVPGYLSDKF GRFNVAIATL LTLFIVMFVG WLPFGTNLTN MYVISALYGF CSGSVFSLLP 360
  361 VCCGQISKTE EFGKRYSTMY FVVGFGTLVG IPITGAIISI KTTADYQHYI IFSGLATFVS 420
  421 AVCYIISRAY CVGFKWVRF

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	3.070581
Match:	PF00083
Description:	Sugar (and other) transporter

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transporter activity	3.3426261924492	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.29689809004391	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
ion transmembrane transporter activity	1.94035843948137	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
cation transmembrane transporter activity	1.5181741634556	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
binding	0.873217664940684	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: