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View Structure Prediction Details

Protein: YOR246C
Organism: Saccharomyces cerevisiae
Length: 330 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YOR246C.

Description E-value Query
Range		 Subject
Range
YOR246C - Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Br...
gi|190407551 - gi|190407551|gb|EDV10818.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
ENV9_YEAST - Probable oxidoreductase ENV9 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ENV9 PE=1 S...
 2.0E-72 [1..330] [1..330]
WWOX_MOUSE - WW domain-containing oxidoreductase OS=Mus musculus GN=Wwox PE=1 SV=1
 8.0E-70 [13..326] [121..408]
HGNC:19979|Ensem... - dehydrogenase 14 (all-trans/9-cis/11-cis)
ENSPTRT00000021764 - null
gi|117645274 - gi|117645274|emb|CAL38103.1| hypothetical protein [synthetic construct]
RDH14 - retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
 3.0E-69 [5..323] [31..330]
gi|15292559 - gi|15292559|gb|AAK93548.1| SD07613p [Drosophila melanogaster]
 3.0E-68 [8..322] [35..318]
gi|115434568, gi... - gi|9663977|dbj|BAB03618.1| putative pod-specific dehydrogenase SAC25 [Oryza sativa Japonica Group], ...
 9.0E-66 [13..322] [30..313]
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...
 1.0E-64 [13..297] [2..243]

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Predicted Domain #1
Region A:
Residues: [1-330] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDPRILPYY DPAVERKIAV VTGGNTGIGW YTVLHLYLHG FVVYICGRNS HKISKAIQEI  60
   61 LAEAKKRCHE DDDGSSPGAG PGPSIQRLGS LHYIHLDLTD LKCVERAALK ILKLEDHIDV 120
  121 LVNNAGIMAV PLEMTKDGFE VQLQTNYISH FIFTMRLLPL LRHCRGRIIS LSSIGHHLEF 180
  181 MYWKLSKTWD YKPNMLFTWF RYAMSKTALI QCTKMLAIKY PDVLCLSVHP GLVMNTNLFS 240
  241 YWTRLPIVGI FFWLLFQVVG FFFGVSNEQG SLASLKCALD PNLSVEKDNG KYFTTGGKES 300
  301 KSSYVSNNVD EAASTWIWTV HQLRDRGFDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.917458
Match: 1cydA_
Description: Carbonyl reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
retinol dehydrogenase activity 2.50453100919665 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
retinoid binding 1.72614743805853 bayes_pls_golite062009
isoprenoid binding 1.61095405873981 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 0.867909552357575 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.82673050487418 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 0.824879127880521 bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity 0.665447800395781 bayes_pls_golite062009
binding 0.355184540089764 bayes_pls_golite062009
retinol binding 0.343379136183648 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 0.311551606659739 bayes_pls_golite062009
NADPH:quinone reductase activity 0.0822919343613215 bayes_pls_golite062009
ethanol binding 0.0448614072391299 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle