YRC Public Data Repository - Protein Structure Prediction

Protein:	HIS3
Organism:	Saccharomyces cerevisiae
Length:	220 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS3.

Description	E-value	Query Range	Subject Range
gi\|39754102 - gi\|39754102\|gb\|AAR30559.1\| His3 [Cloning vector pTARBAC2.1] gi\|5853045 - gi\|5853045\|gb\|AAD54288.1\| HIS3 protein [Cloning vector pRS4213] gi\|23506930 - gi\|23506930\|gb\|AAN31949.1\| imidazoleglycerol-phosphate dehydratase; His3p [Cloning vector YDp-H] gi\|207341048 - gi\|207341048\|gb\|EDZ69214.1\| YOR202Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|39754098 - gi\|39754098\|gb\|AAR30556.1\| His3 [Cloning vector pTARBAC1.3] gi\|224155855, gi... - gi\|224155855\|ref\|XP_002337643.1\| predicted protein [Populus trichocarpa], gi\|222869493\|gb\|EEF06624.1... gi\|63259111 - gi\|63259111\|gb\|AAY40259.1\| HIS3 [Cloning vector pHR307a] HIS7_YEAST - Imidazoleglycerol-phosphate dehydratase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=... gi\|151945293 - gi\|151945293\|gb\|EDN63536.1\| imidazoleglycerol-phosphate dehydratase [Saccharomyces cerevisiae YJM789... HIS3 - Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutatio... gi\|94963137 - gi\|94963137\|gb\|ABF48726.1\| HIS3 [HIS3/URA3 reporter vector pH3U3] gi\|89954460 - gi\|89954460\|gb\|ABD83652.1\| imidazoleglycerolphosphate dehydratase [synthetic construct] gi\|118200046 - gi\|118200046\|gb\|ABK79084.1\| HIS3 [Cloning vector pTARBAC6]	1.0E-96	[1..220]	[1..220]
gi\|13591410 - gi\|13591410\|gb\|AAK29770.1\| His3 [YTT vector B] gi\|13591413 - gi\|13591413\|gb\|AAK29772.1\| His3 [YTT vector C] HIS7_LACK1 - Imidazoleglycerol-phosphate dehydratase OS=Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / CCRC 2... gi\|13591416 - gi\|13591416\|gb\|AAK29774.1\| His3 [YTT vector D] HIS7_LACKL, HIS7... - Imidazoleglycerol-phosphate dehydratase OS=Saccharomyces kluyveri GN=HIS3 PE=3 SV=1, Imidazoleglycer...	8.0E-95	[3..220]	[15..232]
HIS7_ZYGRO - Imidazoleglycerol-phosphate dehydratase OS=Zygosaccharomyces rouxii GN=HIS3 PE=3 SV=1	7.0E-93	[3..220]	[7..226]
HIS7_ZYGBA - Imidazoleglycerol-phosphate dehydratase OS=Zygosaccharomyces bailii GN=HIS3 PE=2 SV=1	2.0E-92	[3..220]	[4..223]
HIS7_CYBJA - Imidazoleglycerol-phosphate dehydratase OS=Cyberlindnera jadinii GN=HIS3 PE=3 SV=1	6.0E-90	[2..219]	[8..223]
HIS7_PICST - Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) (IGPD) - Pichia stipitis (Yeast)	2.0E-89	[4..219]	[3..221]
HIS7_CANAX - Imidazoleglycerol-phosphate dehydratase OS=Candida albicans GN=HIS3 PE=3 SV=1	2.0E-88	[4..219]	[3..221]
jgi\|Picpa1\|39082... - null HIS7_PICPA - Imidazoleglycerol-phosphate dehydratase OS=Komagataella pastoris GN=HIS3 PE=3 SV=1 gi\|238032819, gi... - gi\|254571823\|ref\|XP_002493021.1\| Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step i...	2.0E-87	[4..219]	[7..223]
HIS7_NEUCR - Imidazoleglycerol-phosphate dehydratase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 7... HIS7_NEUCR - Imidazoleglycerol-phosphate dehydratase OS=Neurospora crassa GN=65E11.030 PE=3 SV=1	4.0E-86	[2..219]	[7..227]

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Predicted Domain #1

Region A:
Residues: [1-220]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEQKALVKR ITNETKIQIA ISLKGGPLAI EHSIFPEKEA EAVAEQATQS QVINVHTGIG  60
   61 FLDHMIHALA KHSGWSLIVE CIGDLHIDDH HTTEDCGIAL GQAFKEALGA VRGVKRFGSG 120
  121 FAPLDEALSR AVVDLSNRPY AVVELGLQRE KVGDLSCEMI PHFLESFAEA SRITLHVDCL 180
  181 RGKNDHHRSE SAFKALAVAI REATSPNGTN DVPSTKGVLM

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	109.508638
Match:	PF00475
Description:	Imidazoleglycerol-phosphate dehydratase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
imidazoleglycerol-phosphate dehydratase activity	1.6337728630325	bayes_pls_golite062009
catalytic activity	0.878454819018611	bayes_pls_golite062009
nucleic acid binding	0.369771518688522	bayes_pls_golite062009
structural constituent of ribosome	0.325699575011026	bayes_pls_golite062009
transcription regulator activity	0.212099606954236	bayes_pls_golite062009
structural molecule activity	2.19428886088058E-4	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: