YRC Public Data Repository - Protein Structure Prediction

Protein:	SWT1
Organism:	Saccharomyces cerevisiae
Length:	458 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SWT1.

Description	E-value	Query Range	Subject Range
SWT1 - RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unpr... gi\|151945785 - gi\|151945785\|gb\|EDN64026.1\| conserved protein [Saccharomyces cerevisiae YJM789] SWT1_YEAST - Transcriptional protein SWT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SWT1 PE=1 S... gi\|190407485 - gi\|190407485\|gb\|EDV10752.1\| hypothetical protein SCRG_01559 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..458]	[1..458]
SWT1_SCHPO - Transcriptional protein swt1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=swt1 PE=2 SV=... SPCC24B10.15 - PINc domain	5.0E-51	[84..346]	[2..288]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	7.0E-48	[110..311]	[84..278]
gi\|81301330, gi\|... - gi\|81301330\|ref\|YP_401538.1\| nucleotide binding protein, PINc [Synechococcus elongatus PCC 7942], gi...	1.0E-47	[128..323]	[1..192]
gi\|19923416, gi\|... - gi\|19923416\|ref\|NP_055768.2\| KIAA1008 [Homo sapiens], gi\|189054486\|dbj\|BAG37259.1\| unnamed protein p...	2.0E-47	[110..311]	[42..236]
gi\|194547798, gi... - gi\|84319279\|ref\|ZP_00967678.1\| COG1875: Predicted ATPase related to phosphate starvation-inducible p... gi\|15599114, gi\|... - gi\|9950103\|gb\|AAG07306.1\|AE004809_6 conserved hypothetical protein [Pseudomonas aeruginosa PAO1], gi... gi\|84325361, gi\|... - gi\|84325361\|ref\|ZP_00973398.1\| COG1875: Predicted ATPase related to phosphate starvation-inducible p... gi\|107103436 - gi\|107103436\|ref\|ZP_01367354.1\| hypothetical protein PaerPA_01004506 [Pseudomonas aeruginosa PACS2] gi\|11348112 - pir\|\|E83156 conserved hypothetical protein PA3919 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|115587180, gi... - gi\|46164561\|ref\|ZP_00137357.2\| COG1875: Predicted ATPase related to phosphate starvation-inducible p... gi\|218889800, gi... - gi\|218889800\|ref\|YP_002438664.1\| hypothetical protein PLES_10581 [Pseudomonas aeruginosa LESB58], gi...	8.0E-47	[124..345]	[7..227]
YLAK_BACSU - Uncharacterized protein ylaK OS=Bacillus subtilis GN=ylaK PE=3 SV=1 gi\|221318600 - gi\|221318600\|ref\|ZP_03599894.1\| hypothetical protein BsubsJ_08071 [Bacillus subtilis subsp. subtilis... gi\|221313678 - gi\|221313678\|ref\|ZP_03595483.1\| hypothetical protein BsubsN3_08137 [Bacillus subtilis subsp. subtili... YLAK_BACSU - Uncharacterized protein YlaK OS=Bacillus subtilis (strain 168) GN=ylaK PE=3 SV=1 gi\|221322874 - gi\|221322874\|ref\|ZP_03604168.1\| hypothetical protein BsubsS_08182 [Bacillus subtilis subsp. subtilis...	4.0E-45	[128..341]	[1..203]
gi\|229606941, gi... - gi\|229606941\|ref\|YP_002877589.1\| phosphate starvation-inducible protein PhoH [Vibrio cholerae MJ-123... gi\|229516765, gi... - gi\|229516765\|ref\|ZP_04406211.1\| phosphate starvation-inducible protein PhoH [Vibrio cholerae RC9], g... gi\|229507435, gi... - gi\|229507435\|ref\|ZP_04396940.1\| phosphate starvation-inducible protein PhoH [Vibrio cholerae BX 3302... gi\|126511431, gi... - gi\|153817996\|ref\|ZP_01970663.1\| conserved hypothetical protein [Vibrio cholerae NCTC 8457], gi\|12651... gi\|126520074, gi... - gi\|229509640\|ref\|ZP_04399121.1\| phosphate starvation-inducible protein PhoH [Vibrio cholerae B33], g... gi\|75830557, gi\|... - gi\|75830557\|ref\|ZP_00759833.1\| COG1875: Predicted ATPase related to phosphate starvation-inducible p... gi\|9657090, gi\|1... - gi\|9657090\|gb\|AAF95649.1\| conserved hypothetical protein [Vibrio cholerae O1 biovar El Tor str. N169... gi\|11354718 - pir\|\|E82066 conserved hypothetical protein VC2507 [imported] - Vibrio cholerae (strain N16961 serogr...	3.0E-41	[130..344]	[7..220]
gi\|15615192, gi\|... - gi\|15615192\|ref\|NP_243495.1\| hypothetical protein BH2629 [Bacillus halodurans C-125], gi\|10175250\|db... gi\|25490523 - pir\|\|E83978 hypothetical protein BH2629 [imported] - Bacillus halodurans (strain C-125)	2.0E-40	[128..341]	[1..203]

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Predicted Domain #1

Region A:
Residues: [1-112]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDEKRAFPK GNNHIRSETF NGSVSHKISE SIKDIASLRP HGKYTVQDID NIIASTSSHE  60
   61 NRGQSGDSNG CINHDEEGDI PMCDLNDESD VEMISEYLSS QREMEAQSVA NY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.431	a.47.2	t-snare proteins
View	Download	0.431	a.47.2	t-snare proteins
View	Download	0.388	a.7.6	Ribosomal protein S20
View	Download	0.388	a.7.6	Ribosomal protein S20
View	Download	0.348	a.8.3	Families 57/38 glycoside transferase middle domain
View	Download	0.348	a.8.3	Families 57/38 glycoside transferase middle domain
View	Download	0.320	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.320	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.272	a.7.7	BAG domain
View	Download	0.272	a.7.7	BAG domain
View	Download	0.261	a.26.1	4-helical cytokines
View	Download	0.247	a.181.1	Antibiotic binding domain of TipA-like multidrug resistance regulators
View	Download	0.243	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.243	a.2.3	Chaperone J-domain
View	Download	0.224	a.7.3	Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View	Download	0.214	d.58.26	GHMP Kinase, C-terminal domain
View	Download	0.214	a.61.1	Retroviral matrix proteins
View	Download	0.205	a.26.1	4-helical cytokines
View	Download	0.203	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.201	a.5.3	N-terminal domain of phosphatidylinositol transfer protein sec14p

Predicted Domain #2

Region A:
Residues: [113-317]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKINDDLPL LNPPTLKTAF VVDTNFIISH LNTLEKLRSL SSTYHHLIIV PTTVIQELDG  60
   61 LKKSPDIARD NDDTTNQEHD RTIGTLARWG NDWIYKNLAN LDSGLIGQKL KQSLNPGSLK 120
  121 DDSILDCCLY FKEILNCFVI LLSNDKNLCT KALTEDILTV SFRKNMDAKI IAMRAYEENQ 180
  181 LRFANLRDST VNNFDQNVTS YAHIP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [318-458]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIETPPLQFD KVSQNVFEQV KETIFFAIDH TLRKEYGEDI GFIDYNPDKL TTIENASNYI  60
   61 YLFWVSVFSE LFTCSKIKKN EWKSLPTVLK SKPTNLNDLR TFEQFWETVL HFLFSKFTNE 120
  121 EKQSLEKQIH EWKTSINAIS T

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.530	a.24.3	Cytochromes
View	Download	0.530	a.24.3	Cytochromes
View	Download	0.476	a.24.3	Cytochromes
View	Download	0.451	i.11.1	Computational models partly based on NMR data
View	Download	0.451	i.11.1	Computational models partly based on NMR data
View	Download	0.442	f.18.1	F1F0 ATP synthase subunit A
View	Download	0.442	f.18.1	F1F0 ATP synthase subunit A
View	Download	0.439	a.1.1	Globin-like
View	Download	0.439	a.1.1	Globin-like
View	Download	0.400	a.1.1	Globin-like
View	Download	0.382	a.1.1	Globin-like
View	Download	0.359	a.24.3	Cytochromes
View	Download	0.350	a.19.1	Fertilization protein
View	Download	0.345	a.78.1	Fatty acid responsive transcription factor FadR, C-terminal domain
View	Download	0.308	f.1.4	Bcl-2 inhibitors of programmed cell death
View	Download	0.294	a.25.1	Ferritin-like
View	Download	0.289	a.1.1	Globin-like
View	Download	0.284	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.267	d.198.2	Arp2/3 complex subunits
View	Download	0.263	a.1.1	Globin-like
View	Download	0.261	a.29.3	Acyl-CoA dehydrogenase C-terminal domain-like
View	Download	0.247	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.243	f.1.1	Colicin
View	Download	0.232	a.133.1	Phospholipase A2, PLA2
View	Download	0.229	a.152.1	Antioxidant defence protein AhpD
View	Download	0.227	c.14.1	ClpP/crotonase
View	Download	0.226	a.25.1	Ferritin-like
View	Download	0.219	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.218	d.38.1	Thioesterase/thiol ester dehydrase-isomerase
View	Download	0.212	a.80.1	DNA polymerase III clamp loader subunits, C-terminal domain
View	Download	0.212	a.100.1	6-phosphogluconate dehydrogenase C-terminal domain-like
View	Download	0.211	f.35.1	Multidrug efflux transporter AcrB transmembrane domain
View	Download	0.210	a.63.1	Apolipophorin-III
View	Download	0.210	a.45.1	Glutathione S-transferase (GST), C-terminal domain
View	Download	0.209	a.1.1	Globin-like
View	Download	0.209	d.51.1	Eukaryotic type KH-domain (KH-domain type I)
View	Download	0.207	c.55.1	Actin-like ATPase domain
View	Download	0.207	a.118.9	ENTH/VHS domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits