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View Structure Prediction Details

Protein: SIA1
Organism: Saccharomyces cerevisiae
Length: 622 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIA1.

Description E-value Query
Range
Subject
Range
gi|151945757 - gi|151945757|gb|EDN63998.1| conserved protein [Saccharomyces cerevisiae YJM789]
SIA1 - Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by gluc...
SIA1_YEAST - Protein SIA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIA1 PE=2 SV=1
gi|207341130 - gi|207341130|gb|EDZ69269.1| YOR137Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190407463 - gi|190407463|gb|EDV10730.1| protein SIA1 precursor [Saccharomyces cerevisiae RM11-1a]
0.0 [1..622] [1..622]
YJM5_SCHPO - Uncharacterized protein C1020.05 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC1020....
SPCC1020.05 - phosphoprotein phosphatase
7.0E-70 [218..618] [135..508]
PPA28_ARATH - Probable inactive purple acid phosphatase 28 OS=Arabidopsis thaliana GN=PAP28 PE=2 SV=1
4.0E-64 [283..607] [30..378]
gi|7208777 - gi|7208777|emb|CAB76911.1| putative PTS protein [Cicer arietinum]
2.0E-62 [297..604] [45..375]
gi|25497621 - pir||C97245 probable phosphohydrolase, Icc family [imported] - Clostridium acetobutylicum
gi|15025847, gi|... - gi|15896061|ref|NP_349410.1| Icc family phosphohydrolase [Clostridium acetobutylicum ATCC 824], gi|1...
2.0E-54 [288..604] [16..315]
gi|125529062 - gi|125529062|gb|EAY77176.1| hypothetical protein OsI_05146 [Oryza sativa Indica Group]
gi|115442163, gi... - gi|34906526|ref|NP_914610.1| P0432C03.20 [Oryza sativa (japonica cultivar-group)], gi|215741548|dbj|...
9.0E-51 [307..604] [48..369]

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Predicted Domain #1
Region A:
Residues: [1-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLHYRRRFN FLRRILFILC ITSLYLSRDS LKLHAKNVLM DHNVAEYHGG MIDDIQILRC  60
   61 YHWYRQCSSL YAPKLHPSNT AKKIKDKNSI LWTRVSKNIT VETLYSLQSG PFYNSYLYVH 120
  121 LKDFQSNPKN TIKELAIARD SALIPLQVLR DINKLVKSSD SSVFHNHVYL REKPTSSWWK 180
  181 LLFGISVDTD NIAVFGEEWV YKGSGIWCKY ILNDDDNDAP ITNLEIYLGS SFIESRPSWK 240
  241 EVIHEFHRNN IPSLPISITR KLETKNHHHK FSNGLLGSLR T

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [282-622]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSKDINIQVD ADYKITSPHI QFSRGQRSFK ILQITDFHFK CTDNSMTVIN EIKTVNFIDR  60
   61 VLASENPDLV VITGDLLDSH NTIDYQTCIM KVVQPMISNK IPYAISLGVS DESNLATSAQ 120
  121 IRDFIRNLPY TFNNVASEEG HMAIEVSFKK KLTKNTLLER DIDTEDETNP SEALFFVFDS 180
  181 FAPVNNFLQD YNDLIGKIDF GLAFQYFPLS EYRPHGLFPI IGQYNERSTL TVDTPRSRGQ 240
  241 VSMTINGKHY KSFLDILSLW NIKGVSCGHE HNNDCCLQSK NEMWLCYGGS AGIGLPRIQG 300
  301 IYPTVRLFNL DDILDEITSW KRNSNLVDEV YDYQYIYKGK Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.30103
Match: 1qhwA_
Description: Mammalian purple acid phosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 1.61379532420857 bayes_pls_golite062009
catalytic activity 0.632097679642303 bayes_pls_golite062009
binding 0.0938060766019471 bayes_pls_golite062009
phosphoprotein phosphatase activity 0.0412556599175502 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.0266041407862333 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.0182359198166776 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle