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View Structure Prediction Details

Protein: BAG7
Organism: Saccharomyces cerevisiae
Length: 409 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BAG7.

Description E-value Query
Range
Subject
Range
BAG7_YEAST - Rho-GTPase-activating protein BAG7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BAG7 ...
gi|151945755 - gi|151945755|gb|EDN63996.1| GTPase-activating protein [Saccharomyces cerevisiae YJM789]
BAG7 - Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which pla...
3.0E-85 [1..409] [1..409]
MYO9B - myosin IXB
7.0E-60 [38..385] [1675..2051]
gi|13096922 - gi|13096922|gb|AAH03259.1| Arhgap17 protein [Mus musculus]
1.0E-58 [43..376] [245..553]
gi|19071871 - gi|19071871|dbj|BAB85655.1| Nadrin-102 [Rattus norvegicus]
7.0E-58 [43..376] [245..553]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-57 [3..407] [27..414]

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Predicted Domain #1
Region A:
Residues: [1-145]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNMNLLSTP SSEEGSPQNR SSSMSSVEGK KDRDTFTNLQ NEFDGKVFGV SLEESLKVAQ  60
   61 EEVIIQKSTN EIGSIPVVIA KSGKYLKENA LDTTGIFRIA GSNKRVRELQ AVFSKPPDYG 120
  121 RKFEGWCDFN VHDIATLLKR YLNSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 175.679424
Match: 1grnB_
Description: Cdc42GAP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 5.23789256375467 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 5.21562004568462 bayes_pls_golite062009
small GTPase regulator activity 4.91645234075732 bayes_pls_golite062009
GTPase activator activity 4.81440293338491 bayes_pls_golite062009
Ras GTPase activator activity 4.76400460221691 bayes_pls_golite062009
Rho GTPase activator activity 4.58620967349979 bayes_pls_golite062009
enzyme regulator activity 4.5322075775333 bayes_pls_golite062009
enzyme activator activity 4.29367232260052 bayes_pls_golite062009
Rac GTPase activator activity 3.29568423512865 bayes_pls_golite062009
binding 1.62780792681766 bayes_pls_golite062009
protein binding 1.21496582666968 bayes_pls_golite062009
GTPase binding 0.240141218420366 bayes_pls_golite062009
small GTPase binding 0.0713778754122761 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [146-286]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEPLVPLALY DIFRNPILEN PKINEHKEQI IKDYEDIYML LPQQNRHLIL YLAALLNLFA  60
   61 RNEKKNLMSA SNLAAIVQPS LLSHPKDEMC PKEYEASRTV IEFLILHASD IIPNTEKANK 120
  121 DTMPHAGTVA KFNNITVPEM A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 175.679424
Match: 1grnB_
Description: Cdc42GAP
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [287-409]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDSDEEDFVH PSIDDHMLPR SRALSDSNNF TIHHHHHHHH ALFPSPIDFD NNGLSVPRSF  60
   61 KGRTLSAESL SPRLSKLLGN VGNSSNTGIK DPTERVPRGE HKTKHKQRQS WLRRLTSPSR 120
  121 TQP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle