YRC Public Data Repository - Protein Structure Prediction

Protein:	INP53
Organism:	Saccharomyces cerevisiae
Length:	1107 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INP53.

Description	E-value	Query Range	Subject Range
gi\|929847 - gi\|929847\|emb\|CAA90520.1\| ORF N2160 [Saccharomyces cerevisiae]	1108.0	[0..1]	[1090..1]
gi\|44889477, gi\|... - gi\|44889477\|ref\|NP_982271.1\| synaptojanin 1 isoform b [Homo sapiens], gi\|237757312\|ref\|NP_001153774....	1022.0	[0..18]	[1086..27]
gi\|63237149, gi\|... - gi\|63237149\|gb\|AAB60525.2\| 145 kDa synaptojanin isoform [Rattus norvegicus], gi\|209870039\|ref\|NP_445...	1019.0	[0..18]	[1072..27]
gi\|27806155, gi\|... - gi\|27806155\|ref\|NP_776893.1\| synaptojanin 1 [Bos taurus], gi\|2285875\|dbj\|BAA21652.1\| synaptojanin [B...	1019.0	[0..18]	[1076..27]
gi\|49524475 - gi\|49524475\|emb\|CAG58072.1\| unnamed protein product [Candida glabrata] gi\|49524475, gi\|... - gi\|50285487\|ref\|XP_445172.1\| unnamed protein product [Candida glabrata], gi\|49524475\|emb\|CAG58072.1\|...	1018.0	[0..1]	[1107..1]
gi\|74001109 - gi\|74001109\|ref\|XP_856447.1\| PREDICTED: similar to synaptojanin 1 isoform a isoform 3 [Canis familia...	1006.0	[0..18]	[1068..27]

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Predicted Domain #1

Region A:
Residues: [1-403]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIIFVSEEPE RRLAIVSNLY ALVLKPVGKK PSDKPLCAIE LLQKNDLKKY GFKRLTSHEI  60
   61 FGVIGLIEVN GLLFVGAITG KSKVAQPCPG ETVNKIFAVD FFCLNDNSWD FIEIDSSGYP 120
  121 VLPETASTEY QDALPKHPCY ELKKLLSNGS FYYSSDFDLT STLQHRGYGQ HSLSTDTYEE 180
  181 EYMWNSFLMQ EMITYRDHLD TNLKQILDDE GFLTTVIRGF AETFVSYVKK LKVALTIISK 240
  241 QSWKRAGTRF NARGVDDEAN VANFVETEFI MYSSQYCYAF TQIRGSIPVF WEQGTSLINP 300
  301 RVQITRSFEA TQPVFDKHIM KSVEKYGPVH VVNLLSTKSS EIELSKRYKE HLTHSKKLNF 360
  361 NKDIFLTEFD FHKETSQEGF SGVRKLIPLI LDSLLSSGYY SYD

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	182.769551
Match:	PF02383
Description:	SacI homology domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [404-495]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VREKKNISEQ HGIFRTNCLD CLDRTNLAQQ IISLAAFRTF LEDFRLISSN SFIDDDDFVS  60
   61 KHNTLWADHG DQISQIYTGT NALKSSFSRK GK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.879	a.2.15	Description not found.

Predicted Domain #3

Region A:
Residues: [496-889]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLAGALSDA TKSVSRIYIN NFMDKEKQQN IDTLLGRLPY QKAVQLYDPV NEYVSTKLQS  60
   61 MSDKFTSTSN INLLIGSFNV NGATKKVDLS KWLFPIGEKF KPDIVVLGLQ EVIELSAGSI 120
  121 LNADYSKSSF WENLVGDCLN QYDDKYLLLR VEQMTSLLIL FFVKADKAKY VKQVEGATKK 180
  181 TGFRGMAGNK GAVSIRFEYG ATSFCFVNSH LAAGATNVEE RRSDYESIVR GITFTRTKMI 240
  241 PHHDSIFWLG DMNYRINLPN EDVRRELLNQ EEGYIDKLLH FDQLTLGINS GSVFEGFKEP 300
  301 TLKFRPTYKY DPGTGTYDSS EKERTPSWTD RIIYKGENLL PLSYSDAPIM ISDHRPVYAA 360
  361 YRAKITFVDD KERLSLKKRL FTEYKQEHPE EPGS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	862.67837
Match:	1i9yA
Description:	Synaptojanin, IPP5C domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [890-1107]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LISDLLSLDL DNKSTDGFKS SSESSLLDID PIMAQPTASS VASSSPVSSA SASLQPVRTQ  60
   61 NSSQSRTPIK KPVLRPPPPP AHKSVSAPAP STSKEKSPTP QTSTASLSSV TKNIQENKPL 120
  121 AQNRRIPPPG FSQNILTPKS TSNLASPMSS KVDLYNSASE STRSAQDARQ QTPTAFAASR 180
  181 DVNGQPEALL GDENPIEPEE KAKLNHMTLD SWQPLTPK

[Run NCBI BLAST on this sequence.]

Detection Method:	ab initio
Confidence:	14.34
Match:
Description:	No description for 1ldvA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits