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View Structure Prediction Details

Protein: RGS2
Organism: Saccharomyces cerevisiae
Length: 309 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RGS2.

Description E-value Query
Range		 Subject
Range
RGS2_YEAST - Regulator of G-protein signaling 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RGS2 ...
RGS2 - Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the ...
 2.0E-86 [1..309] [1..309]
AXIN1_CHICK - Axin-1 OS=Gallus gallus GN=AXIN1 PE=2 SV=1
 3.0E-62 [3..268] [59..312]
AXIN1_MOUSE, AXN... - Axin-1 OS=Mus musculus GN=Axin1 PE=1 SV=2, Axin-1 OS=Mus musculus GN=Axin1 PE=1 SV=2
 1.0E-61 [3..268] [188..441]
AXIN1 - axin 1
 2.0E-61 [3..268] [96..349]
AXIN1_RAT - Axin-1 OS=Rattus norvegicus GN=Axin1 PE=1 SV=3
 2.0E-61 [3..268] [125..378]
AXIN1_XENLA - Axin-1 OS=Xenopus laevis GN=axin1 PE=1 SV=1
 5.0E-57 [3..267] [59..311]
gi|24643130, gi|... - gi|7293516|gb|AAF48890.1| CG7095 [Drosophila melanogaster], gi|24643130|ref|NP_573328.1| CG7095 [Dro...
 1.0E-55 [1..251] [467..722]

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Predicted Domain #1
Region A:
Residues: [1-195] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASVPSLCDI LIPLEKNSRS DGDAESSNTV LIQLRKGHHE RMRSPYTIQK FYKFLKRAHC  60
   61 EENLEFFEKA HQFLQLKQNR SISEEKLLEV WNKSLYIKYI AVDSPKECNF SQDTREIFEK 120
  121 CFANNEVPAD VDVLCAISHV MGLLMDGYHR FVSSVNEKKY SATYAHNDSA TEQDLKNEST 180
  181 TSFSSLGVED ISEDR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.0103
Match: 1cmzA_
Description: Galpha interacting protein, GaIP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTPase regulator activity 2.62470634659526 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.60277235167995 bayes_pls_golite062009
binding 2.35238988967981 bayes_pls_golite062009
enzyme regulator activity 2.08722361418883 bayes_pls_golite062009
GTPase activator activity 1.87534424848905 bayes_pls_golite062009
enzyme activator activity 1.62073651679221 bayes_pls_golite062009
protein binding 1.34804002381061 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [196-309] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSYLKKPDIN GLSTIIQETS ANTTNESQCS DRTSRPSESS SSLNTTSSTY KNTSTRNLQK  60
   61 PQNTGILNSG KGLLQKLNFV KKRKSFKQPS GVICSHYNSN VQNRLKGQNS HQQR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle